Abstract
Cerebral radiation necrosis is a serious late complication after conventional radiotherapy that can present with focal neurologic deficits or with more generalized signs and symptoms of increased intracranial pressure, depending on the location. The incidence and severity of radionecrosis are dose-volume dependent. We report a case of cerebral radiation necrosis 5 years after radiotherapy for a maxillary sinus carcinoma.
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Lawrence YR, Li XA, El Naqa I, et al. Radiation dose-volume effects in the brain. Int J Radiat Oncol Biol Phys. 2010;76(3 Suppl):S20–7.
Ruben JD, Dally M, Bailey M, Smith R, McLean CA, Fedele P. Cerebral radiation necrosis: incidence, outcomes, and risk factors with emphasis on radiation parameters and chemotherapy. Int J Radiat Oncol Biol Phys. 2006;65(2):499–508.
Lee AW, Kwong DL, Leung SF, et al. Factors affecting risk of symptomatic temporal lobe necrosis: significance of fractional dose and treatment time. Int J Radiat Oncol Biol Phys. 2002;53(1):75–85.
Lee AW, Ng SH, Ho JH, et al. Clinical diagnosis of late temporal lobe necrosis following radiation therapy for nasopharyngeal carcinoma. Cancer. 1988;61(8):1535–42.
Fontana M, Mastrostefano R, Bernabei A, et al. Bilateral temporal lobectomy for late radionecrosis after radiotherapy for acromegaly. A case report. J Neurosurg Sci. 1984;28(2):107–12.
Minniti G, Traish D, Ashley S, Gonsalves A, Brada M. Risk of second brain tumor after conservative surgery and radiotherapy for pituitary adenoma: update after an additional 10 years. J Clin Endocrinol Metab. 2005;90(2):800–4.
Hoshi M, Hayashi T, Kagami H, Murase I, Nakatsukasa M. Late bilateral temporal lobe necrosis after conventional radiotherapy. Neurol Med Chir (Tokyo). 2003;43(4):213–6.
Wang PC, Tu TY, Liu KD. Cystic brain necrosis and temporal bone osteoradionecrosis after radiotherapy and surgery in a patient of ear carcinoma. J Chin Med Assoc. 2004;67(9):487–91.
Wisoff HS, Llena JF. Glioblastoma multiforme of the cerebellum five decades after irradiation of a cerebellar tumor. J Neurooncol. 1989;7(4):339–44.
Monje ML, Ramakrishna NR, Young G, et al. Durable response of a radiation-induced, high-grade cerebellar glioma to temozolomide. J Neurooncol. 2007;84(2):179–83.
Kumar AJ, Leeds NE, Fuller GN, et al. Malignant gliomas: MR imaging spectrum of radiation therapy- and chemotherapy-induced necrosis of the brain after treatment. Radiology. 2000;217(2):377–84.
Sugahara T, Korogi Y, Tomiguchi S, et al. Posttherapeutic intraaxial brain tumor: the value of perfusion-sensitive contrast-enhanced MR imaging for differentiating tumor recurrence from nonneoplastic contrast-enhancing tissue. AJNR Am J Neuroradiol. 2000;21(5):901–9.
Schwartz RB, Carvalho PA, Alexander E 3rd, Loeffler JS, Folkerth R, Holman BL. Radiation necrosis vs high-grade recurrent glioma: differentiation by using dual-isotope SPECT with 201TI and 99mTc-HMPAO. AJNR Am J Neuroradiol. 1991;12(6):1187–92.
Rahman M, Hoh BL. Avastin in the treatment for radiation necrosis: exciting results from a recent randomized trial. World Neurosurg. 2011;75(1):4–5.
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This work was supported in part by grants from NIH 3P30CA023100-25S8 to S. Kesari.
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Madhava R. Kanakamedala and Ali Mahta are co-first authors.
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Kanakamedala, M.R., Mahta, A., Liu, J. et al. Late temporal lobe necrosis after conventional radiotherapy for carcinoma of maxillary sinus. Med Oncol 29, 2456–2458 (2012). https://doi.org/10.1007/s12032-011-0141-4
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DOI: https://doi.org/10.1007/s12032-011-0141-4