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Association Between Paraoxonase Gene Polymorphisms and Intracerebral Hemorrhage in a Korean Population

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Abstract

The human paraoxonase (PON) gene family includes three members: PON1, PON2, and PON3. PON, which prevents the oxidative modification of lipoproteins, has been implicated as a potential risk factor of the cerebrovascular disease. In this study, we investigated associations between coding region single-nucleotide polymorphisms (cSNPs) of PON1, PON2, and PON3 genes and intracerebral hemorrhage (ICH) in a Korean population. Six cSNPs [rs13306698 and rs662 for PON1; rs12026 and rs7493 for PON2; rs13226149 and rs1053275 for PON3] were genotyped using direct sequencing in 145 ICH patients and 372 control subjects. Of the six cSNPs, rs12026 and rs7493, which were in complete linkage disequilibrium, were associated with ICH in log-additive (GC vs. CC vs. GG, p = 0.0008, OR = 0.53, 95 % CI = 0.36–0.78) and dominant models (GC/CC vs. GG, p = 0.0006, OR = 0.47, 95 % CI = 0.30–0.73). In addition, rs13226149 was associated with ICH in log-additive model (GA vs. AA vs. GG, p = 0.0033, OR = 0.58, 95 % CI = 0.39–0.84). In the allele frequency analysis, the C alleles of rs12026 and rs7493 and the A allele of rs13226149 were also shown to contribute to the decreased risk of ICH (p = 0.001, OR = 0.55, 95 % CI = 0.38–0.80 in rs12026 and rs7493; p = 0.003, OR = 0.58, 95 % CI = 0.40–0.83 in rs13226149). These results suggest that PON genes may be involved in the susceptibility of ICH.

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Acknowledgements

This work was supported by a grant from Kyung Hee University in 2012 (KHU-20121738).

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Authors and Affiliations

  1. Kohwang Medical Research Institute, School of Medicine, Kyung Hee University, 26 Kyunghee-daero, 130-701, Dongdaemun-gu, Seoul, Republic of Korea

    Hae Jeong Park, Su Kang Kim, Hyun-Kyung Park & Joo-Ho Chung

  2. Department of Emergency Medicine, School of Medicine, Kyung Hee University, Dongdaemun-gu, Seoul, Republic of Korea

    Hae Jeong Park

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  1. Hae Jeong Park
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Correspondence to Joo-Ho Chung.

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Supplementary Fig 1

Linkage disequilibrium (LD) block between single nucleotide polymorphisms (SNPs) of the PON genes. Six SNPs of the PON genes were analyzed for LD using Haploview 4.2. LD block (block 1) is constructed between rs7493 and rs12026 (D′ = 1.00, r 2 = 1.00). Black shading indicates strong LD. The numbers within quadrangles mean D′ × 100 (DOCX 514 kb)

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Park, H.J., Kim, S.K., Park, HK. et al. Association Between Paraoxonase Gene Polymorphisms and Intracerebral Hemorrhage in a Korean Population. J Mol Neurosci 57, 410–416 (2015). https://doi.org/10.1007/s12031-015-0620-8

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  • DOI: https://doi.org/10.1007/s12031-015-0620-8

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