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Association of Neurotensin Receptor 1 Gene Polymorphisms with Processing Speed in Healthy Chinese-Han Subjects

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Abstract

Neurotensin modulates dopamine and serotonin transmission in the brain. The study investigated whether genetic polymorphisms in the Neurotensin receptor 1 gene were associated with performance on processing speed and executive function. A total of 129 healthy Chinese-Han volunteers were recruited. Genotyping for three SNPs, including rs6090453, rs6011914, and rs2427422, was analyzed by using a PCR and a restriction fragment length polymorphism analysis. Performances of processing speed and executive function were assessed by using Trail Making Test-A (TMT-A), Wisconsin Card Sorting Test, and Stroop Color-Word Test. We found significant differences in the outcomes of TMT-A score among rs6090453C/G (F (2,126) = 4.405, P = 0.014) and rs2427422A/G (F (2,126) = 7.498, P = 0.001) genotypes. Neurotensin receptor 1 SNP polymorphisms were significantly associated with the variance in processing speed performance in a sample of Chinese college students.

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References

  • Azmi N, Norman C, Spicer CH, Bennett GW (2006) Effects of a neurotensin analogue (PD149163) and antagonist (SR142948A) on the scopolamine-induced deficits in a novel object discrimination task. Behav Pharmacol 17:357–362

    Article  CAS  PubMed  Google Scholar 

  • Binder EB, Kinkead B, Owens MJ, Nemeroff CB (2001) Neurotensin and dopamine interactions. Pharmacol Rev 53:453–486

    CAS  PubMed  Google Scholar 

  • Carraway R, Leeman SE (1973) The isolation of a new hypotensive peptide, neurotensin, from bovine hypothalami. J Biol Chem 248:6854–6861

    CAS  PubMed  Google Scholar 

  • Feifel D, Melendez G, Shilling PD (2003) A systemically administered neurotensin agonist blocks disruption of prepulse inhibition produced by a serotonin-2A agonist. Neuropsychopharmacology 28:651–653

    Article  CAS  PubMed  Google Scholar 

  • Huang Y, Li J, Wu L et al (2012) Association between a casein kinase 1 epsilon gene polymorphism and schizophrenia in a Chinese Han population. J Mol Neurosci 47:470–474

    Article  CAS  PubMed  Google Scholar 

  • Jomphe C, Lemelin PL, Okano H, Kobayashi K, Trudeau LE (2006) Bidirectional regulation of dopamine D2 and neurotensin NTS1 receptors in dopamine neurons. Eur J Neurosci 24:2789–2800

    Article  CAS  PubMed  Google Scholar 

  • Kitabgi P (2002) Targeting neurotensin receptors with agonists and antagonists for therapeutic purposes. Curr Opin Drug Discov Devel 5:764–776

    CAS  PubMed  Google Scholar 

  • Kremen WS, Jacobsen KC, Xian H et al (2007) Genetics of verbal working memory processes: a twin study of middle-aged men. Neuropsychology 21:569–580

    Article  PubMed  Google Scholar 

  • Li J, Chen C, Chen C et al (2011) Neurotensin receptor 1 gene (NTSR1) polymorphism is associated with working memory. PLoS One 6:e17365

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Ma H, Huang Y, Zhang B et al (2013) Association between neurotensin receptor 1 (NTR1) gene polymorphisms and schizophrenia in a Chinese-Han population. J Mol Neurosci 50:345–352

    Article  CAS  PubMed  Google Scholar 

  • McAllister TW, Tyler AL, Flashman LA et al (2012) Polymorphisms in the brain-derived neurotrophic factor gene influence memory and processing speed one month after brain injury. J Neurotrauma 29:1111–1118

    Article  PubMed Central  PubMed  Google Scholar 

  • Petkova-Kirova P, Rakovska A, Zaekova G et al (2008) Stimulation by neurotensin of dopamine and 5-hydroxytryptamine (5-HT) release from rat prefrontal cortex: possible role of NTR1 receptors in neuropsychiatric disorders. Neurochem Int 53:355–361

    Article  CAS  PubMed  Google Scholar 

  • Shugalev NP, Stavrovskaya AV, Ol’shanskii AS, Hartmann G, Lenard L (2008) Serotoninergic mechanisms of the effects of neurotensin on passive avoidance behavior in rats. Neurosci Behav Physiol 38:517–521

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgments

This article was supported by research grants from the Scientific Research Fund of Liaoning Science and Technology Agency, China (No. 2011225020) and the Scientific Research Fund of the First Hospital of CMU (No. FSFH1301).

Conflict of Interest

The authors have no conflict of interest to declare.

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Authors and Affiliations

  1. Department of Psychiatry, The First Hospital of China Medical University, Shenyang, China

    Man Wang, Ying-lin Huang & Gang Zhu

  2. Mental Health Institute, The Second Xiangya Hospital of Central South University, Changsha, China

    Man Wang & Jing-ping Zhao

  3. Center for Mental Health, Yanshan University, Qinhuangdao, China

    Hui Ma

  4. Nanjing Bei Street 155, Shenyang, 110001, China

    Gang Zhu

Authors
  1. Man Wang
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  2. Hui Ma
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  3. Ying-lin Huang
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  4. Gang Zhu
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  5. Jing-ping Zhao
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Corresponding author

Correspondence to Gang Zhu.

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The authors have not signed an agreement with any sponsor of the study reported in this article that has a clause which prevents them from publishing both positive and negative results, from collaborating with other investigators to pool data across sites, or that forbids them from publishing without the approval of the sponsor.

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Wang, M., Ma, H., Huang, Yl. et al. Association of Neurotensin Receptor 1 Gene Polymorphisms with Processing Speed in Healthy Chinese-Han Subjects. J Mol Neurosci 54, 787–789 (2014). https://doi.org/10.1007/s12031-014-0404-6

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  • DOI: https://doi.org/10.1007/s12031-014-0404-6

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