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Signal Transducer and Activator of Transcription 2 (STAT2) Metabolism Coupling Postmitotic Outgrowth to Visual and Sound Perception Network in Human Left Cerebrum by Biocomputation

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Abstract

We constructed the high-expression signal transducer and activator of transcription 2 (STAT2) metabolism coupling postmitotic outgrowth to visual and sound perception network in human left cerebrum compared with low-expression (fold change ≥2) chimpanzee left cerebrum in GEO data set by using integration of gene regulatory network inference method with gene ontology (GO) analysis of STAT2-activated up- and downstream network. Our result showed that upstream RECQL, PDIA2, ENOSF1, THBS4, RASGRP1, PER2, PDE8A, ORC2L, DCI, OGG1_2, SMA4, GPD1, etc. activated STAT2, and downstream STAT2-activated GSTM3_1, GOSR1, SH3BGR, OSBPL8, PHYH, SAPS2, C21orf33, PDIA2, TRAPPC6A, ENOSF1, CAMTA1, GTF2I_2, etc. in human left cerebrum. STAT2-activated network enhanced regulation of small GTPase-mediated signal transduction, regulation of transcription, regulation of mitosis, regulation of cell growth, positive regulation of phosphoinositide 3-kinase cascade, positive regulation of fat cell differentiation, negative regulation of DNA replication, negative regulation of progression through cell cycle, cyclic nucleotide metabolism, lipid metabolism, carbohydrate metabolism, vitamin A metabolism, N-acetylglucosamine metabolism, UDP-N-acetylgalactosamine metabolism, fatty acid transport, intracellular protein transport, vesicle-mediated transport, lipid transport, retrograde transport, Ras protein signal transduction, Wnt receptor signaling pathway, nervous system development, cell extension, cell adhesion, cell differentiation, circadian rhythm, generation of precursor metabolites and energy, establishment of blood-nerve barrier, visual perception, sensory perception of sound, and poly-N-acetyllactosamine biosynthesis, as a result of inducing metabolism coupling postmitotic outgrowth to visual and sound perception in human left cerebrum.

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References

  • Alberghina M, Viola M (1989) Region-selective decline of in vivo lipid synthesis in the aged rat visual system. Mol Chem Neuropathol 11(2):109–122

    Article  PubMed  CAS  Google Scholar 

  • Battelle BA, Hart MK (2002) Histamine metabolism in the visual system of the horseshoe crab Limulus polyphemus. Comp Biochem Physiol A Mol Integr Physiol 133(1):135–142

    Article  PubMed  Google Scholar 

  • Buxhoeveden DP, Casanova MF (2002) The minicolumn and evolution of the brain. Brain Behav Evol 60(3):125–151

    Article  PubMed  Google Scholar 

  • Caceres M et al (2003) Elevated gene expression levels distinguish human from non-human primate brains. Proc Natl Acad Sci USA 100(22):13030–13035

    Article  PubMed  CAS  Google Scholar 

  • Cheng D et al (2011) Lipid pathway alterations in Parkinson’s disease primary visual cortex. PLoS One 6(2):e17299

    Article  PubMed  CAS  Google Scholar 

  • Dahlhaus M et al (2011) The synaptic proteome during development and plasticity of the mouse visual cortex. Mol Cell Proteomics 5:M110 005413

    Google Scholar 

  • Dewar AJ, Reading HW (1970) Nervous activity and RNA metabolism in the visual cortex of rat brain. Nature 225(5235):869–870

    Article  PubMed  CAS  Google Scholar 

  • Donahue MJ et al (2009) Cerebral blood flow, blood volume, and oxygen metabolism dynamics in human visual and motor cortex as measured by whole-brain multi-modal magnetic resonance imaging. J Cereb Blood Flow Metab 29(11):1856–1866

    Article  PubMed  CAS  Google Scholar 

  • Gu J, Gu X (2003) Induced gene expression in human brain after the split from chimpanzee. Trends Genet 19(2):63–65

    Article  PubMed  CAS  Google Scholar 

  • Hessel E et al (2003) Signal transduction in the visual cascade involves specific lipid–protein interactions. J Biol Chem 278(25):22853–22860

    Article  PubMed  CAS  Google Scholar 

  • Huang J et al (2010a) Interferon α-Inducible protein 27 computational network construction and comparison between the frontal cortex of HIV encephalitis (HIVE) and HIVE-control patients. Open Genomics J 3(1875-693X):1–8

    Article  Google Scholar 

  • Huang JX, Wang L, Jiang MH (2010b) TNFRSF11B computational development network construction and analysis between frontal cortex of HIV encephalitis (HIVE) and HIVE-control patients. J Inflamm (Lond) 7:50

    Article  CAS  Google Scholar 

  • Maya Vetencourt JF et al (2011) Serotonin triggers a transient epigenetic mechanism that reinstates adult visual cortex plasticity in rats. Eur J Neurosci 33(1):49–57

    Article  PubMed  Google Scholar 

  • Murillo-Maldonado JM et al (2011) Drosophila insulin pathway mutants affect visual physiology and brain function besides growth, lipid, and carbohydrate metabolism. Diabetes 60(5):1632–1636

    Article  PubMed  CAS  Google Scholar 

  • Niehusmann P et al (2011) Mitochondrial dysfunction due to Leber’s hereditary optic neuropathy as a cause of visual loss during assessment for epilepsy surgery. Epilepsy Behav 20(1):38–43

    Article  PubMed  Google Scholar 

  • Nowak JZ, Nawrocki J (1985) Transport, metabolism and the role of vitamin A in the vision process. II. Metabolism of vitamin A in the visual cycle. Klin Oczna 87(12):512–513

    PubMed  CAS  Google Scholar 

  • Oliveira CS et al (2008) The activation of ERK1/2 and p38 mitogen-activated protein kinases is dynamically regulated in the developing rat visual system. Int J Dev Neurosci 26(3–4):355–362

    Article  PubMed  CAS  Google Scholar 

  • Prestwich KN, O'Sullivan K (2005) Simultaneous measurement of metabolic and acoustic power and the efficiency of sound production in two mole cricket species (Orthoptera: Gryllotalpidae). J Exp Biol 208(Pt 8):1495–1512

    Article  PubMed  Google Scholar 

  • Preuss TM, Coleman GQ (2002) Human-specific organization of primary visual cortex: alternating compartments of dense Cat-301 and calbindin immunoreactivity in layer 4A. Cereb Cortex 12(7):671–691

    Article  PubMed  Google Scholar 

  • Storey JD (2002) A direct approach to false discovery rates. J Roy Stat Soc Ser B 64:479–498

    Article  Google Scholar 

  • Sun T, Walsh CA (2006) Molecular approaches to brain asymmetry and handedness. Nat Rev Neurosci 7(8):655–662

    Article  PubMed  CAS  Google Scholar 

  • Sun Y, Wang L, Lui L (2008) Integrative decomposition procedure and Kappa statistics set up ATF2 ion binding module in malignant pleural mesothelioma (MPM). Front of Electrical Electron Eng in China 3(4):381–387

    Article  Google Scholar 

  • Sun Y et al (2010) Secreted phosphoprotein 1 upstream invasive network construction and analysis of lung adenocarcinoma compared with human normal adjacent tissues by integrative biocomputation. Cell Biochem Biophys 56(2–3):59–71

    Article  PubMed  CAS  Google Scholar 

  • Sun L, et al (2011) Glycogen debranching enzyme 6 (AGL), enolase 1 (ENOSF1), Ectonucleotide Pyrophosphatase 2 (ENPP2_1), glutathione S-transferase 3 (GSTM3_3) and mannosidase (MAN2B2) metabolism computational network analysis between chimpanzee and human left cerebrum. Cell Biochem Biophys 61(3):493–505

  • Toga AW, Collins RC (1981) Glucose metabolism increases in visual pathways following habituation. Physiol Behav 27(5):825–834

    Article  PubMed  CAS  Google Scholar 

  • Wang Y et al (2006) Inferring gene regulatory networks from multiple microarray datasets. Bioinformatics 22(19):2413–2420

    Article  PubMed  CAS  Google Scholar 

  • Wang J et al (2007) Inhibition of the c-Jun N-terminal kinase-mediated mitochondrial cell death pathway restores auditory function in sound-exposed animals. Mol Pharmacol 71(3):654–666

    Article  PubMed  CAS  Google Scholar 

  • Wang L et al (2009a) FOS proliferating network construction in early colorectal cancer (CRC) based on integrative significant function cluster and inferring analysis. Cancer Invest 27(8):816–824

    Article  PubMed  CAS  Google Scholar 

  • Wang L et al (2009b) Integrative decomposition procedure and Kappa statistics for the distinguished single molecular network construction and analysis. J Biomed Biotechnol 2009:726–728

    Google Scholar 

  • Wang L, Huang J, Jiang M (2010a) RRM2 computational phosphoprotein network construction and analysis between no-tumor hepatitis/cirrhotic liver tissues and human hepatocellular carcinoma (HCC). Cell Physiol Biochem 26(3):303–310

    Article  PubMed  CAS  Google Scholar 

  • Wang L et al (2010b) AFP computational secreted network construction and analysis between human hepatocellular carcinoma (HCC) and no-tumor hepatitis/cirrhotic liver tissues. Tumour Biol 31(5):417–425

    Article  PubMed  Google Scholar 

  • Wang L, et al (2011) Survivin (BIRC5) cell cycle computational network in human no-tumor hepatitis/cirrhosis and hepatocellular carcinoma transformation. J Cell Biochem 112:1286–1294

    Google Scholar 

  • Yu L, Yang SJ (2011) AMP-activated protein kinase mediates activity-dependent regulation of peroxisome proliferator-activated receptor gamma coactivator-1alpha and nuclear respiratory factor 1 expression in rat visual cortical neurons. Neuroscience 169(1):23–38

    Article  Google Scholar 

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Acknowledgments

This work was supported by the National Natural Science Foundation in China (No. 60871100) and (No. 61171114), the Returned Overseas Chinese Scholars for Scientific research Foundation of State Education Ministry, Significant Science and Technology Project for New Transgenic Biological Species (2009ZX08012-001B), Automatical Scientific Planning of Tsinghua University (20111081023 and 20111081010), State Key Lab of Pattern Recognition Open Foundation.

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Authors and Affiliations

  1. Biomedical Center, School of Electronic Engineering, Beijing University of Posts and Telecommunications, Beijing, 100876, China

    Lin Wang, Juxiang Huang & Hong Lin

  2. Lab of Computational Linguistics, School of Humanities and Social Sciences, Tsinghua University, Beijing, 100084, China

    Minghu Jiang

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  1. Lin Wang
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  2. Juxiang Huang
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  3. Minghu Jiang
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  4. Hong Lin
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Correspondence to Lin Wang.

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Lin Wang, Juxiang Huang, and Minghu Jiang equally contributed to this work.

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Wang, L., Huang, J., Jiang, M. et al. Signal Transducer and Activator of Transcription 2 (STAT2) Metabolism Coupling Postmitotic Outgrowth to Visual and Sound Perception Network in Human Left Cerebrum by Biocomputation. J Mol Neurosci 47, 649–658 (2012). https://doi.org/10.1007/s12031-011-9702-4

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  • DOI: https://doi.org/10.1007/s12031-011-9702-4

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