Article

Journal of Molecular Neuroscience

, Volume 42, Issue 3, pp 459-463

Open Access This content is freely available online to anyone, anywhere at any time.

Acute Homeostatic Responses to Increased Fat Consumption in MCH1R Knockout Mice

  • Shinjae ChungAffiliated withDepartment of Pharmacology, University of CaliforniaDepartment of Developmental and Cell Biology, University of California Irvine
  • , Timothy WongAffiliated withDepartment of Pharmacology, University of California
  • , Hiroshi NagasakiAffiliated withDepartment of Metabolic Medicine, School of Medicine, Nagoya University
  • , Olivier CivelliAffiliated withDepartment of Pharmacology, University of CaliforniaDepartment of Developmental and Cell Biology, University of California IrvineDepartment of Pharmaceutical Sciences, University of California Irvine Email author 

Abstract

Melanin-concentrating hormone (MCH) is a hypothalamic neuropeptide which has been shown to regulate energy homeostasis. Using genetic knockout mice lacking the MCH1 receptor (MCH1R), we investigated how these mice adapt to metabolic changes caused by excessive caloric consumption. We show that the MCH system is one of the players mediating behavioral and metabolic responses upon increased caloric consumption. MCH1R knockout mice showed decreased tendency of food intake upon exposure to a high-fat diet. They also are resistant to gain weight upon high-fat diet by increasing fat metabolism. Therefore, the MCH system is important in regulating metabolic responses upon various environmental stimuli such as high-fat diet.

Keywords

Melanin-concentrating hormone Energy homeostasis G protein-coupled receptor Neuropeptide