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Neuroprotective Protein and Carboxypeptidase E

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Abstract

This review outlines the neuroprotective activities and structural specificities of two distinct proteins, activity-dependent neuroprotective protein, a protein assigned transcription factor/chromatin remodeling activity, and carboxypeptidase E, a classic exopeptidase. Future studies will elucidate how these two versatile proteins converge onto a similar endpoint: neuroprotection.

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Acknowledgments

We would like to thank Chip Dye and Dr. Vincent Schram (Microscopy and Imaging Core, Eunice Kennedy Shriver National Institute of Child Health and Development, National Institutes of Health) for assistance with microscopic imaging and Dr. Douglas E. Brenneman for critical reading of the manuscript. This study was done in collaboration between Dr. Y. Peng Loh and Prof. Illana Gozes under the support of: The United States Israel Binational Science Foundation, the Lily and Avraham Gildor Chair for the Investigation of Growth Factors, The Adams Super Center for Brain Studies, the Dr. Diana and Zelma Elton (Elbaum) Laboratory for Molecular Neuroendocrinology, the Intramural Research Program of the Eunice Kennedy Shriver National Institute of Child Health, and Human Development and Allon Therapeutics Inc. Prof. Gozes serves as the chief Scientific Officer of Allon Therapeutics Inc.

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Authors and Affiliations

  1. Section on Cellular Neurobiology, Program on Developmental Neuroscience, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, 20892, USA

    Hisatsugu Koshimizu, Vladimir Senatorov & Y. Peng Loh

  2. Elton Laboratory for Molecular Neuoendocrinology, Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, 69978, Israel

    Illana Gozes

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  1. Hisatsugu Koshimizu
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  2. Vladimir Senatorov
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  3. Y. Peng Loh
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  4. Illana Gozes
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Correspondence to Y. Peng Loh or Illana Gozes.

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Koshimizu, H., Senatorov, V., Loh, Y.P. et al. Neuroprotective Protein and Carboxypeptidase E. J Mol Neurosci 39, 1–8 (2009). https://doi.org/10.1007/s12031-008-9164-5

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  • DOI: https://doi.org/10.1007/s12031-008-9164-5

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