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Prevalence of Helicobacter pylori Infection in Patients with Squamous Cell Carcinoma of the Oesophagus. A Descriptive Case Series Study

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Abstract

Introduction

Helicobacter pylori is an important causative factor in gastric carcinogenesis; its role in extra-gastric gastrointestinal malignancies such as oesophageal cancer is controversial. H. pylori is thought to cause extensive gastric atrophy associated with squamous cell carcinoma of the oesophagus. We conducted a study to determine the prevalence of H. pylori infection in patients with squamous cell carcinoma of the oesophagus.

Method

We collected biopsies from the antrum and corpus of 59 patients with confirmed squamous cell carcinoma of the oesophagus, two from each area. These were then examined by an experienced histopathologist using methylene blue staining for the presence of H. pylori.

Results

H. pylori was found in 30 (51 %) of the patients, a prevalence similar to that of the general population in South Africa. Five patients were found to have associated intestinal metaplasia, and all but two had chronic inflammation.

Conclusion

The prevalence of H. pylori in our patients with squamous cell carcinoma of the oesophagus is 51 %, similar to that previously reported in the general population.

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References

  1. Rokkas T, Pistiolas D, Sechapoulos P, et al. Relationship between helicobacter pylori Infection and esophageal neoplasm: A meta-analysis. Clin Gastroenterol Hepatol. 2007;5(12):1413–7.

    Article  PubMed  Google Scholar 

  2. Nie S, Chen T, Yang X, et al. Association of Helicobacter pylori infection with oesophageal adenocarcinoma and squamous cell carcinoma: a meta-analysis. Dis Esophagus. 2014;27(7):645–53.

    Article  CAS  PubMed  Google Scholar 

  3. Xie F-J, Zhang Y-P, Zheng Q-Q, et al. Helicobacter pylori infection and esophageal cancer risk: an updated meta-analysis. World J Gastroenterol. 2013;19(36):6098–107.

    Article  PubMed  PubMed Central  Google Scholar 

  4. Islami F, Ramanga F. Helicobacter pylori and esophageal cancer risk: a meta-analysis. Cancer Prev Res. 2008;1(5):329–151.

    Article  CAS  Google Scholar 

  5. Khoshbaten M, Zadimani A, Boyadi MR, et al. Helicobacter pylori infection reduces the risk of esophageal squamous cell carcinoma: a case control study in Iran. Asian Pac J Cancer Prev. 2011;12:149–151.

    PubMed  Google Scholar 

  6. Tanih NF, Clarke AM, Mkwetshana N, et al. Helicobacter pylori infection in Africa: pathological and microbiological diagnosis. Afr J Biotechnol. 2008;7(25):4653–62.

    Google Scholar 

  7. Hunt RH, Xiao SD, Megraud F, et al. Helicobacter pylori in developing countries. World Gastroenterology Organisation Global Guidelines. August 2010.

  8. Tahih NF, Okeye BI, Ndip LM, et al. Helicobacter pylori prevalence in dyspeptic patients. S Afr Med J. 2010:734-7.

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Authors and Affiliations

  1. University of Pretoria, Pretoria, Gauteng, South Africa

    Mpho Kgomo, A A Elnagar, T. Mokoena, C Jeske & G J Nagel

Authors
  1. Mpho Kgomo
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  2. A A Elnagar
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  3. T. Mokoena
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  4. C Jeske
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  5. G J Nagel
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Corresponding author

Correspondence to Mpho Kgomo.

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Conflict of Interest

The study was approved by the University of Pretoria Faculty of Health Science Ethics Committee and found to be compliant with ethical standards. There was no funding for this study. All authors have no conflicts of interest to declare as such.

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Kgomo, M., Elnagar, A.A., Mokoena, T. et al. Prevalence of Helicobacter pylori Infection in Patients with Squamous Cell Carcinoma of the Oesophagus. A Descriptive Case Series Study. J Gastrointest Canc 47, 396–398 (2016). https://doi.org/10.1007/s12029-016-9838-0

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  • DOI: https://doi.org/10.1007/s12029-016-9838-0

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