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Dietary Lifestyle and Colorectal Cancer Onset, Recurrence, and Survival: Myth or Reality?

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Abstract

Background and Purpose

Interest in the possibility that diet might help to reduce the risk of colorectal cancer dates back to 1970 based on both the large variation in rates of specific cancers in different countries and the impressive changes observed in the incidence of cancer in migrants from low- to high-risk areas. Here, we report the state of art of literature data about this topic.

Methods

Three sections have been separately considered: chemoprevention of first tumor onset, chemoprevention of recurrence after surgery, and chemoprevention of polyp recurrence in the course of the follow-up of subjects with elevated risk. A particular attention has been pointed to dietary factors and survival, whose relevance is showing a growing interest.

Results

The relationship between diet and colorectal cancer has been extensively studied about the onset, sometimes with controversial results. Its influence on recurrence and survival has been examined in only few studies.

Conclusions

Literature data are convincing for a protective role on the onset of preneoplastic and neoplastic lesions for some foods such as fibers, vitamin A and D, folic acid, calcium, antioxidants, and promising perspectives for some substances such as phyto-estrogens. Less evidence-based data are available on the possibility to avoid the recurrence of the disease or to affect its mortality with dietary habits. Future perspectives will be directed be not only to identify new dietary style able to prevent the onset of neoplastic lesion of the colon but also to realize an effective chemoprevention.

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References

  1. Yan L, Spitznagel EL, Bosland MC. Soy consumption and colorectal cancer risk in humans: a meta-analysis. Cancer Epidemiol Biomarkers Prev. 2010;19(1):148–58.

    Article  PubMed  CAS  Google Scholar 

  2. Armstrong B, Doll R. Environmental factors and cancer incidence and mortality in different countries, with special reference to dietary practices. Int J Cancer. 1975;15(4):617–31.

    Article  PubMed  CAS  Google Scholar 

  3. Burkitt DP. Possible relationship between bowel cancer and dietary habits. Pro R Soc Med. 1971;64(9):964–5.

    CAS  Google Scholar 

  4. Beliveau R, Gingras D. Role of nutrition in preventing cancer. Can Fam Physician. 2007;53(11):1905–11.

    PubMed  Google Scholar 

  5. Michels KB, Fuchs CS, Giovannucci E, et al. Fiber intake and incidence of colorectal cancer among 76.947 women and 47.279 men. Canc Epidemiol Biomarkers Prev. 2005;14:842–9.

    Article  Google Scholar 

  6. Macrae F. Wheat brean fiber and development of adenomatous polyps evidence from randomized, controlled clinical trials. Am J Med. 1999;106(1A):38S–42S.

    Article  PubMed  CAS  Google Scholar 

  7. Klurfeld DM. Fiber and cancer protection-mechanisms. Adv Exp Med Biol. 1997;427:249–57.

    Article  PubMed  CAS  Google Scholar 

  8. Wiseman M. The second Word Cancer Research Fund/American Institute for Cancer Research exper report. Food, nutrition, physical activity, and the prevention of cancer: a global perspective. Proc Nutr Soc. 2008;67(3):253–6.

    Article  PubMed  Google Scholar 

  9. World Health Organization. Diet Nutrition and the prevention of chronic disease. Report of a Joint FAO/WHO Expert Consultation. WHO Technical Report Series. 2003, No916.

  10. Linseisen J, Rohrmann S, Miller AB, et al. Fruit and vegetable consumption and lung cancer risk: updated information from the European Prospective Investigation into Cancer and Nutrition (EPIC). Int J Cancer. 2007;121(5):1103–14.

    Article  PubMed  CAS  Google Scholar 

  11. Park Y, Hunter DJ, Spiegelman D, Bergkvist L, Berrino F, van den Brandt PA, et al. Dietary fiber and risk of colorectal cancer: a pooled analysis of prospective cohort studies. JAMA. 2005;294(22):2849–57.

    Article  PubMed  CAS  Google Scholar 

  12. Nomura AM, Wilkens LR, Murphy SP, et al. Association of vegetable, fruit and grain intakes with colorectal cancer: the Multiethnic Cohort Study. Am J Clin Nutr. 2008;88(3):730–7.

    PubMed  CAS  Google Scholar 

  13. Schatzkin A, Mouw T, Park Y, Subar AF, Kipnis V, Hollenbeck A, et al. Dietary fiber and whole-grain consumption in relation to colorectal cancer in the NIH-AARP Diet and Health Study. Am J Clin Nutr. 2007;85(5):1353–60.

    PubMed  CAS  Google Scholar 

  14. Beresford SA, Johnson KC, Ritenbaugh C, et al. Low-fat diet pattern and risk of colorectal cancer: the Women’s Health Initiative Randomized Controlled Dietary Modification Trial. JAMA. 2006;295(6):643–54.

    Article  PubMed  CAS  Google Scholar 

  15. Satia-Abouta J, Galanko JA, Martin CF, Ammerman A, Sandler RS. Food groups and colon cancer risk in African-Americans and Caucasians. Int J Cancer. 2004;109:728–36.

    Article  PubMed  CAS  Google Scholar 

  16. Giovannucci E, Goldin B. The role of fat, fatty acids, and total energy intake in the etiology of human colon cancer. Am J Clin Nutr. 1997;66:1564–71.

    Google Scholar 

  17. Howe GR, Aronson KJ, Benito E, Castelleto R, Cornee J, et al. The relationship between dietary fat intake and risk of colorectal cancer: evidence from the combined analysis of 13 case–control studies. Canc Causes Contr. 1997;8:215–28.

    Article  CAS  Google Scholar 

  18. Nkondjock A, Shatenstein B, Maisonneuve P, Ghadirian P. Assessment of risk associated with specific fatty acids and colorectal cancer among French-Canadians in Montreal: a case–control study. Int J Epidemiol. 2003;32:200–9.

    Article  PubMed  Google Scholar 

  19. Theodoratou E, McNeill G, Cetnarskyj R, Farrington SM, Tenesa A, et al. Dietary fatty acids and colorectal cancer: a case–control study. Am J Epidemiol. 2007;166:181–95.

    Article  PubMed  Google Scholar 

  20. Lin J, Zhang SM, Cook NR, Lee IM, Buring JE. Dietary fat and fatty acids and risk of colorectal cancer in women. Am J Epidemiol. 2004;160:1011–22.

    Article  PubMed  Google Scholar 

  21. MacLean CH, Newberry SJ, Mojica WA, et al. Effects of omega-3 fatty acids on cancer risk: a systematic review. JAMA. 2006;295:403–15.

    Article  PubMed  CAS  Google Scholar 

  22. Slattery ML, Benson J, Ma KN, Schaffer D, Potter JD. Trans-fatty acids and colon cancer. Nutr Cancer. 2001;39:170–5.

    Article  PubMed  CAS  Google Scholar 

  23. Sonoshita M, Takaku K, Oshima M, Sugihara K, Taketo MM. Ciclooxygenase-2 expression in fibroblasts and endothelial cells of intestinal polyps. Cancer Res. 2003;62(23):6846–9.

    Google Scholar 

  24. Takeda M, Sonoshita M, Oshima H, Saugihara K, Chulad PC, Langenbach R, et al. Cooperation of cyclooxigenase 1 and cyclooxigenase 2 in intestinal polyps. Cancer Res. 2003;63(16):4872–7.

    PubMed  CAS  Google Scholar 

  25. Kargman SL, O’Neill GP, Vickers PJ, Evans JF, Mancini JA, Jothy S. Expression of prostaglandin G/H synthase-1 and -2 protein in human colon cancers. Cancer Res. 1995;55(12):2556–9.

    PubMed  CAS  Google Scholar 

  26. Eberhart CE, Coffey RJ, Radhika A, Giardiello FM, Ferrenbach S, DuBois RN. Up-regulation of cyclooxigenase 2 gene expression in human colorectal adenomas and adenocarcinomas. Gastroenterology. 1994;107:1183–8.

    Google Scholar 

  27. Sano H, Kawahito Y, Wilder RL, Hashiramoto A, Muhai S, Kimura S, et al. Expression of cyclooxigenase-1 and -2 in human colorectal cancer. Cancer Res. 1995;55(17):3785–9.

    PubMed  CAS  Google Scholar 

  28. Chan TA. Cyclooxigenase inhibition and mechanisms of colorectal cancer prevention. Curr Cancer Drug Targets. 2003;3(6):455–63.

    Article  PubMed  CAS  Google Scholar 

  29. Kitamura T, Itoh M, Noda T, Matsuura M, Wakabayashi K. Combined effects of cyclooxigenase -1 and cyclooxigenase -2 selective inhibitors on intestinal tumorigenesis in adenomatous polyps coli gene knockout mice. Int J Cancer. 2004;109:576–80.

    Article  PubMed  CAS  Google Scholar 

  30. Rothwell PM, Wilson M, Elwin CE, et al. Long-term effect of aspirin on colorectal cancer incidence and mortality: 20-year follow-up of five randomized trials. Lancet. 2004;376:1741–50.

    Article  CAS  Google Scholar 

  31. Sanderson P, Johnson IT, Mathers JC, et al. Emerging diet-related surrogate end points for colorectal cancer: UK Food Standards Agency diet and colonic health workshop report. Br J Nutr. 2004;91:315–23.

    Article  PubMed  CAS  Google Scholar 

  32. Frommel TO, Dyavanapalli M, Oldham T, et al. Effect of aspirin on prostaglandin E2 and leukotriene B4 production in human colonic mucosa from cancer patients. Clin Cancer Res. 1997;3:209–13.

    PubMed  CAS  Google Scholar 

  33. Demeyer D, Honikel K, De Smet S. The World Cancer Research Fund report 2007: a challenge for the meat processing industry. Meat Sci. 2008;80(4):953–9.

    Article  PubMed  Google Scholar 

  34. Larsson SC, Wolk A. Meat consumption and risk of colorectal cancer: a meta-analysis of prospective studies. Int J Cancer. 2006;119(11):2657–64.

    Article  PubMed  CAS  Google Scholar 

  35. Norat T, Lukanova A, Ferrari P, Riboli E. Meat consumption and colorectal cancer risk: dose–response meta-analysis of epidemiological studies. Int J Cancer. 2002;98(2):241–56.

    Article  PubMed  CAS  Google Scholar 

  36. Sandhu M, White I, Mcpherson K. Systematic review of the prospective cohort studies on meat consumption and colorectal cancer risk: a meta-analytical approach. Canc Epidemiol Biomarkers Prev. 2001;10:439–46.

    CAS  Google Scholar 

  37. Santarelli RL, Pierre F, Corpet DE. Processed meat and colorectal cancer: a review of epidemiologic and experimental evidence. Nutr Cancer. 2008;60(2):131–44.

    Article  PubMed  CAS  Google Scholar 

  38. Bingham SA, Pignatelli B, Pollock JRA, et al. Does increased endogenous formation of N-nitroso compounds in the human colon explain the association between red meat and colon cancer? Carcinogenesis. 1996;17(3):515–23.

    Article  PubMed  CAS  Google Scholar 

  39. Lunn JC, Kuhnle G, Mai V, et al. The effect of haem in red and processed meat on the endogenous formation of N-nitroso compounds in the upper gastrointestinal tract. Carcinogenesis. 2007;28(3):685–90.

    Article  PubMed  CAS  Google Scholar 

  40. Sugimura T, Wakabayashi K, Nakagama H, Nagao M. Heterocyclic amines: mutagens/carcinogens produced during cooking of meat and fish. Cancer Sci. 2004;95(4):290–9.

    Article  PubMed  CAS  Google Scholar 

  41. Sinha R, Rothman N, Brown ED, et al. High concentrations of the carcinogen 2-amino-1-methyl-6-phenylimidazo-[4,5-b]pyridine (PhIP) occur in chicken but are dependent on the cooking method. Cancer Res. 1995;55(20):4516–9.

    PubMed  CAS  Google Scholar 

  42. Stavric B. Biological significance of trace levels of mutagenic heterocyclic aromatic amines in human diet: a critical review. Food Chem Toxicol. 1994;32(10):977–94.

    Article  PubMed  CAS  Google Scholar 

  43. Sesink ALA, Termont DSML, Kleibeuker JH, Vandermeer R. Red meat and colon cancer: the cytotoxic and hyperproliferative effects of dietary heme. Cancer Res. 1999;59(22):5704–9.

    PubMed  CAS  Google Scholar 

  44. Pierre F, Freeman A, Tache S, Van der Meer R, Corpet DE. Beef meat and blood sausage promote the formation of azoxymethane-induced mucin-depleted foci and aberrant crypt foci in rat colons. J Nutr. 2004;134(10):2711–6.

    PubMed  CAS  Google Scholar 

  45. Pierre F, Santarelli R, Tache S, Gueraud F, Corpet DE. Beef meat promotion of dimethylhydrazine-induced colorectal carcinogenesis biomarkers is suppressed by dietary calcium. Br J Nutr. 2008;99(5):1000–6.

    Article  PubMed  CAS  Google Scholar 

  46. Pierre F, Tache S, Petit CR, Van der Meer R, Corpet DE. Meat and cancer: haemoglobin and haemin in a low-calcium diet promote colorectal carcinogenesis at the aberrant crypt stage in rats. Carcinogenesis. 2003;24(10):1683–90.

    Article  PubMed  CAS  Google Scholar 

  47. Lubin F, Rozen P, Arieli B, Farbstein M, Knaani Y, Bat L, et al. Nutritional and lifestyle habits and water-fiber interaction in colorectal adenoma etiology. Cancer Epidemiol Biomarkers Prev. 1997;6(2):79–85.

    PubMed  CAS  Google Scholar 

  48. Glade MJ. Food, nutrition, and the prevention of cancer: a global perspective. American Institute for Cancer Research/World Cancer Research Fund, American Institute for Cancer Research, 1997. Nutrition. 1999;15(6):523–6.

    Article  PubMed  CAS  Google Scholar 

  49. Calle EE, Thun MJ. Obesity and cancer. Oncogene. 2004;23(38):6365–78.

    Article  PubMed  CAS  Google Scholar 

  50. Weijenberg MP, Mullie PF, Brants HA, Heinen MM, Goldbohm RA, van den Brandt PA. Dietary glicemic load, glycemic index and colorectal cancer risk: results from the Netherlands Cohort Study. Int J Cancer. 2008;122(3):620–9.

    Article  PubMed  CAS  Google Scholar 

  51. Baron JA, Beach M, Mandel JS, et al. Calcium supplements for the prevention of colorectal adenomas. Calcium Polyp Prevention Study Group. N Engl J Med. 1999;340:101–7.

    Article  PubMed  CAS  Google Scholar 

  52. Levine AJ, Harper JM, Ervin CM, et al. Serum 25-hydroxyvitaminD, dietary calcium intake, and distal colorectal adenoma risk. Nutr Cancer. 2001;39:35–41.

    Article  PubMed  CAS  Google Scholar 

  53. Peters U, Mc Glynn KA, Chatterjee N, et al. Vitamin D, calcium, and vitamin D receptor polymorphism in colorectal adenomas. Cancer Epidemiol Biomarkers Prev. 2001;10:1267–74.

    PubMed  CAS  Google Scholar 

  54. Diaz GD, Paraskeva C, Thomas MG, Binderup L, Hague A. Apoptosis is induced by the active metabolite of vitamin D3 and its analogue EB1089 in colorectal adenoma and carcinoma cells: possible implications for prevention and therapy. Cancer Res. 2000;60:2304–12.

    PubMed  CAS  Google Scholar 

  55. Lappe JMT. Vitamin D and calcium supplementation reduces cancer risk: results of a randomized trial. Am J Clin Nutr. 2007;85:1586–91.

    PubMed  CAS  Google Scholar 

  56. Wactawski-Wende J, Kotchen JM, Anderson GL, Assaf AR, Brunner RL, O’Sullivan MJ, et al. Calcium plus vitamin D supplementation and the risk of colorectal cancer. N Engl J Med. 2006;354:684–96.

    Article  PubMed  CAS  Google Scholar 

  57. Bonithon-Kopp C, Kronborg O, Giacosa A, Rath U, Faivre J, Bonithon-Kopp C, et al. Calcium and fibre supplementation in prevention of colorectal adenoma recurrence: a randomised intervention trial. European Cancer Prevention Organisation Study Group. Lancet. 2000;356:1300–6.

    Article  PubMed  CAS  Google Scholar 

  58. Baron JA, Beach M, Mandel JS, van Stolk RU, Haile RW, Sandler RS, et al. Calcium supplements and colorectal adenomas. Polyp Prevention Study Group. Ann N Y Acad Sci. 1999;889:138–45.

    Article  PubMed  CAS  Google Scholar 

  59. Miller EA, Keku TO, Satia JA, Martin CF, Galanko JA, Sandler RS. Calcium, vitamin D, and apoptosis in the rectal epithelium. Cancer Epidemiol Biomarkers Prev. 2005;14(2):525–8.

    Article  PubMed  CAS  Google Scholar 

  60. Choi SW, Mason JB. Folate status: effects on pathways of colorectal carcinogenesis. J Nutr. 2001;132:2413–8.

    Google Scholar 

  61. Kim YI. Folate and colorectal cancer: an evidence-based critical review. Mol Nutr Food Res. 2007;51:267–92.

    Article  PubMed  CAS  Google Scholar 

  62. Stevens VL, McCullough ML, Sun J, Jacobs EJ, Campbell PT, Gapstur SM. High levels of folate from supplements and fortification are not associated with increased risk of colorectal cancer. Gastroenterology. 2011;141:98–105.

    Article  PubMed  CAS  Google Scholar 

  63. Cole BF, Baron JA, Sandler RS, et al. Polyp prevention study group: folic acid for the prevention of colorectal adenomas: a randomized clinical trial. JAMA. 2007;297:2351–9.

    Article  PubMed  CAS  Google Scholar 

  64. Sie KK, Medline A, van Wee lJ, Sohn KJ, Choi SW, Croxford R, et al. Effect of maternal and postweaning folic acid supplementation on colorectal cancer risk in the off spring. Gut. 2011;60:1687–94.

    Article  PubMed  CAS  Google Scholar 

  65. Bjelakovic G, Nikolova D, Simonetti RG, Gluud C. Systematic review: primary and secondary prevention of gastrointestinal cancers with antioxidant supplements. Aliment Pharmacol Ther. 2008;28:689–703.

    Article  PubMed  CAS  Google Scholar 

  66. Bjelakovic G, Nikolova D, Simonetti RG, Gluud C. Antioxidant supplements for preventing gastrointestinal cancers. Cochrane Database Syst Rev 2008; Issue 4, Art No. CD004183.

  67. Gingras D, Bèliveau R. Colorectal cancer prevention through dietary and lifestyle modifications. Cancer Microenvir. 2011;4:133–9.

    Article  CAS  Google Scholar 

  68. Yang G. Prospective cohort study of soy-food intake and colorectal cancer risk in women. Am J Clin Nutr. 2009;89:577–83.

    Article  PubMed  CAS  Google Scholar 

  69. Cotterchio M, Boucher BA, Manno M, Gallinger S, Okey A, Harper P. Dietary phytoestrogens intake is associated with reduced colorectal cancer risk. J Nutr. 2006;136:3046–53.

    PubMed  CAS  Google Scholar 

  70. Flood DM, Weiss NS, Cook LS, Emerson JC, Schwartz SM, Potter JD. Colorectal cancer incidence in Asian migrants to the United states and their descendants. Canc Causes Control. 2000;11(5):403–11.

    Article  CAS  Google Scholar 

  71. Koo JH, Leong RW. Sex differences in epidemiological, clinical and pathological characteristics of colorectal cancer. J Gastroenterol Hepatol. 2010;25(1):33–42.

    Article  PubMed  Google Scholar 

  72. Kostantinopoulos PA, Kominea A, Vandoros G, et al. Oestrogen receptor beta (ERβ) is abundantly expressed in normal colonic mucosa, but declines in colon adenocarcinoma paralleling the tumor’s dedifferentiation. Eur J Cancer. 2003;39(9):1251–8.

    Article  CAS  Google Scholar 

  73. Kennelly R, Kavanagh DO, Hogan AM, Winter DC. Oestrogen and the colon; potential mechanisms for cancer prevention. Lancet oncol. 2008;9(4):385–91.

    Article  PubMed  CAS  Google Scholar 

  74. Gingras D, Bèliveau R. Colorectal cancer prevention through dietary and lifestyle modifications. Cancer Microenvir. 2011;4:133–9.

    Article  CAS  Google Scholar 

  75. Turner JV, Agatonovi-Kustrin S, Glass BD. Molecular aspects of phytoestrogen selective binding at estrogen receptors. J Pharm Sci. 2007;96(8):1879–85.

    Article  PubMed  CAS  Google Scholar 

  76. Budhathoki S, Joshi AM, Ohnaka K, et al. Soy food and isoflavone intake and colorectal cancer risk: the Fukuoka colorectal cancer study. Scand J Gastroenterol. 2011;201(46):165–72.

    Article  CAS  Google Scholar 

  77. Lechner D, Kallay E, Cross HS. Phytoestrogens and colorectal cancer prevention. Vitamins Horm. 2005;70:169–98.

    Article  CAS  Google Scholar 

  78. Kuijsten A, Arts IC, Hollman PC, van’t Veer P, Kampman E. Plasma enterolignans are associated with lower colorectal adenoma risk. Cancer Epidemiol Biomarkers Prev. 2006;15(6):1132–6.

    Article  PubMed  CAS  Google Scholar 

  79. Ward H, Chapelais G, Kuhnle GG, Luben R, Khaw KT, Bingham S. Lack of prospective associations between plasma and urinary phytoestrogens and risk of prostate or colorectal cancer in the European prospective into cancer-Norfolk study. Cancer Epidemiol Biomarkers Prev. 2008;17(10):2891–4.

    Article  PubMed  CAS  Google Scholar 

  80. Barone M, Tanzi S, Lofano K, Scavo MP, Pricci M, Demarinis L, et al. Dietary induced ERβ up-regulation counteracts intestinal neoplasia development in intacte male ApcMin/+ mice. Carcinogenesis. 2010;31(2):269–74.

    Article  PubMed  CAS  Google Scholar 

  81. Giovannucci E, Rimm EB, Ascherio A, Stampfer MJ, Colditz GA, Willett WC. Alcohol, low-e-low folate diets and risk of colon cancer in men. J Natl Cancer Inst. 1995;87(4):265–73.

    Article  PubMed  CAS  Google Scholar 

  82. Seitz HK, Simanowski UA, Homann N, Waldherr R. Cell proliferation and its evaluation in the colorectal mucosa: effect of ethanol. Z Gastroenterol. 1998;36(8):645–55.

    PubMed  CAS  Google Scholar 

  83. Davis CD, Milner JA. Gastrointestinal microflora, food componence and colon cancer prevention. J Nutr Biochem. 2009;20(10):743–52.

    Article  PubMed  CAS  Google Scholar 

  84. Patterson RE, Neuhouser ML, Hedderson MM, Schwartz SM, Standish LJ, Bowen DJ. Changes in diet, physical activity, and supplement use among adults diagnosed with cancer. J Am Diet Assoc. 2003;103:323–8.

    PubMed  Google Scholar 

  85. Satia JA, Campbell MK, Galanko JA, JamesA CC, Sandler RS. Longitudinal changes in lifestyle behaviors and health status in colon cancer survivors. Cancer Epidemiol Biomarkers Prev. 2004;13:1022–31.

    PubMed  Google Scholar 

  86. Reedy J, Haines PS, Steckler A, Campbell MK. Qualitative comparison of dietary choices and dietary supplement use among older adults with and without a history of colorectal cancer. J Nutr Educ Behav. 2005;37:252–8.

    Article  PubMed  Google Scholar 

  87. Slattery ML, French TK, Egger MJ, Lyon JL. Diet and survival of patients with colon cancer in Utah: is there an association? Int J Epidemiol. 1989;18:792–7.

    Article  PubMed  CAS  Google Scholar 

  88. Park SM, Lim MK, Shin SA, Yun YH. Impact of prediagnosis smoking, alcohol, obesity, and insulin resistance on survival in male cancer patients: National Health Insurance Corporation Study. J Clin Oncol. 2006;24:5017–24.

    Article  PubMed  Google Scholar 

  89. Dray X, Boutron-Ruault MC, Bertrais S, Sapinho D, Benhamiche-Bouvier AM, Faivre J. Influence of dietary factors on colorectalcancer survival. Gut. 2003;52:868–73.

    Article  PubMed  CAS  Google Scholar 

  90. Zell JA, McEligot AJ, Ziogas A, Holcombe RF, Anton-Culver H. Differential effects of wine consumption on colorectal cancer outcomes based on family history of the disease. Nutr Cancer. 2007;59:36–45.

    Article  PubMed  Google Scholar 

  91. Tian J, Chen ZC, Hang LF. The effects of nutrition status of patients with digestive system cancers on prognosis of the disease. Cancer Nurs. 2008;31:462–7.

    Article  PubMed  Google Scholar 

  92. Asghari-Jafarabadi M, Hajizadeh E, Kazemnejad A, Fatemi SR. Site specific evaluation of prognostic factors on survival in Iranian colorectal cancer patients:a competing risks survival analysis. Asian Pac J Cancer Prev. 2009;10:815–21.

    PubMed  CAS  Google Scholar 

  93. Zell JA, Ignatenko NA, Yerushalmi HF, et al. Risk and risk reduction involving arginine intake and meat consumption in colorectal tumori- genesis and survival. Int J Cancer. 2007;120:459–68.

    Article  PubMed  CAS  Google Scholar 

  94. Skeie G, Braaten T, Hjartaker A, Brustad M, Lund E. Cod liver oil, other dietary supplements and survival among cancer patients with solid tumours. Int J Cancer. 2009;12:1155–60.

    Article  CAS  Google Scholar 

  95. Ng K, Meyerhardt JA, Wu K, et al. Circulating 25-hydroxyvitamin d levels and survival in patients with colorectal cancer. J Clin Oncol. 2008;26:2984–91.

    Article  PubMed  CAS  Google Scholar 

  96. Wolpin BM, Wei EK, Ng K, et al. Prediagnostic plasma folate and the risk of death in patients with colorectal cancer. J Clin Oncol. 2008;26:3222–8.

    Article  PubMed  Google Scholar 

  97. Meyerhardt JA, Niedzwiecki D, Hollis D, et al. Association of dietary patterns with cancer recurrence and survival in patients with stage III colon cancer. JAMA. 2007;298:754–64.

    Article  PubMed  CAS  Google Scholar 

  98. Leung EY, Crozier JE, Talwar D, et al. Vitamin antioxidants, lipid peroxidation, tumour stage, the systemic inflammatory response and survival in patients with colorectal cancer. Int J Cancer 2008;123: 2460–4.

    Google Scholar 

  99. Bystro MP, Bjorkegren K, Larsson A, Johansson L, Berglund A. Serum vitamin B12 and folate status among patients with chemotherapy treatment for advanced colorectal cancer. Ups J Med Sci. 2009;114:160–4.

    Article  Google Scholar 

  100. Ng K, Wolpin BM, Meyerhardt JA, et al. Prospective study of predictors of vitamin D status and survival in patients with colorectal cancer. Br J Cancer. 2009;101:916–23.

    Article  PubMed  CAS  Google Scholar 

  101. Bonithon-Kopp C, Piard F, Fenger C, et al. Colorectal adenoma characteristics as predictors of recurrence. Dis Colon Rectum. 2004;47:323–33.

    Article  PubMed  CAS  Google Scholar 

  102. Neugut AI, Jacobson JS, Ahsan H, et al. Incidence and recurrence rates of colorectal adenomas: a prospective study. Gastroenterology. 1995;108:402–8.

    Article  PubMed  CAS  Google Scholar 

  103. Wegener M, Borsch G, Schmidt G. Colorectal adenomas. Distribution, incidence of malignant transformation, and rate of recurrence. Dis Colon Rectum. 1986;29:383–7.

    Article  PubMed  CAS  Google Scholar 

  104. Avidan B, Sonnenberg A, Schnell TG, Leya J, Metz A, Sontag SJ. New occurrence and recurrence of neoplasms within 5 years of a screening colonoscopy. Am J Gastroenterol. 2002;97:1524–9.

    Article  PubMed  Google Scholar 

  105. Koushik A, Hunter DJ, Spiegelman D, et al. Fruits, vegetables and colon cancer risk in a pooled analysis of 14 cohort studies. J Natl Cancer Inst. 2007;99(19):1471–83.

    Article  PubMed  Google Scholar 

  106. Beresford SA, Johnson KC, Ritenbaugh C, et al. Low-fat dietary pattern and risk: the Women’s Health Initiative Randomized Controlled Dietary Modification Trial. JAMA. 2006;295(6):443–52.

    Article  Google Scholar 

  107. Alberts DS, Martinez ME, Roe DJ, et al. Lack of effect of a high-fiber cereal supplement on the recurrence of colorectal adenomas. Phoenix Colon Cancer Prevention Physicians’ Network. N Engl J Med. 2000;342(16):1156–62.

    Article  PubMed  CAS  Google Scholar 

  108. Schatzin A, Lanza E, Freedman LS, et al. The Polyp Prevention Trial I: rationale, design, recruitment, and baseline partecipants characteristics. Cancer Epidemiol Biomarkers Prev. 1996;5(5):375–83.

    Google Scholar 

  109. Sansbury LB, Wanke K, Albert PS, et al. The effect of strict adherence to a high-fiber, high-fruit and -vegetable and low-fat eating pattern on adenoma recurrence. Am J Epidemiol. 2009;170(5):576–84.

    Article  PubMed  Google Scholar 

  110. Methy N, Binquet C, Boutron-Ruault MC, Paillot B, Faivre J, Bonithon-Kopp C. Dietary fatty acids and recurrence of colorectal adenomas in a European interventional trial. Nutr Cancer. 2008;60(5):560–7.

    Article  PubMed  CAS  Google Scholar 

  111. Nakamura T, Ishikawa H, Takeyama I, et al. Excessive fat restriction might promote the recurrence of colorectal adenomas. Nutr Cancer. 2010;62(2):154–63.

    Article  PubMed  CAS  Google Scholar 

  112. Martinez ME, Jacobs ET, Ashbeck EL, et al. Meat intake, preparation methods, mutagens and colorectal adenoma recurrence. Carcinogenesis. 2007;28(9):2019–27.

    Article  PubMed  CAS  Google Scholar 

  113. Mathew A, Sinha R, Burt R, et al. Meat intake and the recurrence of colorectal adenomas. Eur J Cancer Prev. 2004;13(3):159–64.

    Article  PubMed  CAS  Google Scholar 

  114. Baron JA, Beach M, Mandel JS, et al. Calcium supplements for the prevention of colorectal adenomas. Calcium Polyp Prevention Study Group [see comment]. N Engl J Med. 1999;340:101–7.

    Article  PubMed  CAS  Google Scholar 

  115. Shaukat A, Scouras N, Schunemann HJ. Role of supplemental calcium in the recurrence of colorectal adenomas: A meta-analysis of randomized controlled trials. Am J Gastroenterol. 2005;100:390–4.

    Article  PubMed  CAS  Google Scholar 

  116. Wactawski-Wende J, Kotchen JM, Anderson GL, et al. Calcium plus vitamin D supplementation and the risk of colorectal cancer. N Engl J Med. 2006;354:684–96.

    Article  PubMed  CAS  Google Scholar 

  117. Greenberg ER, Baron JA, Tosteson TD. A clinical trial of antioxidant vitamins to prevent colorectal adenoma. Polyp Prevention Study Group. N Engl J Med. 1994;331:141–7.

    Article  PubMed  CAS  Google Scholar 

  118. Baron JA, Cole BF, Mott L, Haile R, Grau M, Church TR, et al. Neoplastic and antineoplastic effects of beta carotene on colorectal adenoma recurrence: results of a randomized trial. J Natl Cancer Inst. 2003;95:717–22.

    Article  PubMed  CAS  Google Scholar 

  119. Steck-Scott S, Forman MR, Sowell A, et al. Carotenoids, vitamin A and risk of adenomatous polyp recurrence in the polyp prevention trial. Int J Cancer. 2004;112(2):295–305.

    Article  PubMed  CAS  Google Scholar 

  120. Di Leo et al. Dietary Estrogen Receptor β agonists impact proliferative and apoptotic biomarkers in the colon mucosa. A randomized placebo-controlled study. Abstract 19th UEGW 2011.

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Authors and Affiliations

  1. Department of Emergency and Organ Transplantation, Section of Gastroenterology, Bari, Italy

    Katia Lofano, Mariabeatrice Principi, Maria Principia Scavo, Maria Pricci & Alfredo Di Leo

  2. Department of Medical Sciences, Section of Gastroenterology, Foggia, Italy

    Enzo Ierardi

  3. Gastroenterology Unit, Department of Emergency and Organ Transplantation (DETO), University of Bari, Piazza Giulio Cesare 11, 70124, Bari, Italy

    Alfredo Di Leo

Authors
  1. Katia Lofano
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  2. Mariabeatrice Principi
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  3. Maria Principia Scavo
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  4. Maria Pricci
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  5. Enzo Ierardi
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  6. Alfredo Di Leo
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Correspondence to Alfredo Di Leo.

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Lofano, K., Principi, M., Scavo, M.P. et al. Dietary Lifestyle and Colorectal Cancer Onset, Recurrence, and Survival: Myth or Reality?. J Gastrointest Canc 44, 1–11 (2013). https://doi.org/10.1007/s12029-012-9425-y

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