Abstract
Background
Both esophageal carcinoma and HTLV-1 (Human T cell lymphotropic virus 1) have high prevalence in northeastern of Iran.
Objective
To assess the presence of HTLV-1 genome in esophageal cancerous tissue and in tissues from non cancerous individuals.
Methods
Eighty five patients with esophageal squamous cell carcinoma and 48 non-cancerous control patients that underwent esophagogasteroscopy for other reasons were included in this study. All selected subjects are residing in northeastern part of Iran. All specimens were studied histopathologically by H&E staining and were evaluated for HTLV-1 by PCR method. In PCR, the presence of tax, pol, env and LTR segments of HTLV-1 genome were detected.
Results
Male to female ratio in the case group was 3 to 5. Average age and standard deviation in case and control group were 56 ± 17 and 54 ± 21 years, respectively; which did not have any significant differences. All the patients came from the same area in the northeastern part of Iran. HTLV-1 genome was found in two subjects with esophageal cancer and in one subject in the control group. Statistical analysis showed no significant differences between the two groups (chi square = 0.26, Fisher exact test P value = 0.7, Odd ratio = 1.13 [0.08 < OR < 32.46]).
Conclusion
HTLV-1 infection and esophageal squamous cell carcinoma did not appear to have a significant correlation.
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Acknowledgment
This study was conducted under supervision and financial support of Research Department of Islamic Azad University of Mashhad. Authors wish to thank the staff of pathology department of Omid hospital and BuAli research center.
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Mirsadraee, M., Kalantari, M.R., Saffari, A. et al. Association of HTLV1 Infection and Esophageal Squamous Cell Carcinoma. J Gastrointest Canc 38, 15–18 (2007). https://doi.org/10.1007/s12029-008-9008-0
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DOI: https://doi.org/10.1007/s12029-008-9008-0