Review Article

Neurocritical Care

, Volume 18, Issue 1, pp 118-130

First online:

Influenza-Associated Neurological Complications

  • Jenny P. TsaiAffiliated withDepartment of Medicine, Division of Neurology, University of Toronto Email author 
  • , Andrew J. BakerAffiliated withDepartments of Critical Care and Anesthesia, St. Michael’s Hospital, University of TorontoDepartment of Anesthesia and Inter-Departmental Division of Critical Care, University of Toronto

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While mostly diagnosed in the pediatric population, neurological complications of pandemic influenza A infection may affect young and previously healthy adults, and may follow a fulminant, severe, and occasionally fatal course. We reviewed severe neurological complications secondary to influenza infection reported in the literature, in attempt to outline recurrent syndromes that may assist the clinician in making a timely diagnosis. Vigilance and awareness of these clinical entities are key in the neurologist and intensivist’s role in surveillance and early recognition of pandemic influenza, and in ensuring improved survival for affected patients.


Influenza Influenza vaccine Encephalopathy Brain edema H1N1 Coma