Skip to main content

Advertisement

SpringerLink
Log in

The truth on IgD in the ploy of immune surveillance and inflammation

  • Letter to the Editor
  • Published:
Immunologic Research Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Black CA. A brief history of the discovery of the immunoglobulins and the origin of the modern immunoglobulin nomenclature. Immunol Cell Biol. 1997;75:65–8.

    Article  CAS  PubMed  Google Scholar 

  2. Ohta Y, Flajnik M. IgD, like IgM, is a primordial immunoglobulin class perpetuated in most jawed vertebrates. Proc Natl Acad Sci USA. 2006;103:10723–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Sun Z, Almogren A, Furtado PB, Chowdhury B, Kerr MA, Perkins SJ. Semi-extended solution structure of human myeloma immunoglobulin D determined by constrained X-ray scattering. J Mol Biol. 2005;353:155–73.

    Article  CAS  PubMed  Google Scholar 

  4. Loset GA, Roux KH, Zhu P, Michaelsen TE, Sandlie I. Differential segmental flexibility and reach dictate the antigen binding mode of chimeric IgD and IgM: implications for the function of the B cell receptor. J Immunol. 2004;172:2925–34.

    Article  CAS  PubMed  Google Scholar 

  5. Preud’homme JL, Petit I, Barra A, Morel F, Lecron JC, Lelièvre E. Structural and functional properties of membrane and secreted IgD. Mol Immunol. 2000;37:871–87.

    Article  PubMed  Google Scholar 

  6. Rowe DS, Hug K, Forni L, Pernis B. Immunoglobulin D as a lymphocyte receptor. J Exp Med. 1973;138:965–72.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Walsh GM, Kay AB. Binding of immunoglobulin classes and subclasses to human neutrophils and eosinophils. Clin Exp Immunol. 1986;63:466–72.

    CAS  PubMed  PubMed Central  Google Scholar 

  8. Hunyadi J, Hamerlinck F, Cormane RH. Immunoglobulin and complement bearing polymorphonuclear leukocytes in allergic contact dermatitis and psoriasis vulgaris. Br J Dermatol. 1976;94:417–22.

    Article  CAS  PubMed  Google Scholar 

  9. Yuan D, Dang T, Bibi R. Inappropriate expression of IgD from a transgene inhibits the function of antigen-specific memory B cells. Cell Immunol. 2001;211:61–70.

    Article  CAS  PubMed  Google Scholar 

  10. Brandtzaeg P, Surjan L Jr, Berdal P. Immunoglobulin-producing cells in clinically normal, hyperplastic and inflamed human palatine tonsils. Acta Otolaryngol. 1979;360(Suppl):211–5.

    CAS  Google Scholar 

  11. Chen K, Xu W, Wilson M, He B, Miller NW, Bengtén E, Edholm ES, Santini PA, Rath P, Chiu A, Cattalini M, Litzman J, Bussel JB, Huang B, Meini A, Riesbeck K, Cunningham-Rundles C, Plebani A, Cerutti A. Immunoglobulin D enhances immune surveillance by activating antimicrobial, proinflammatory and B cell-stimulating programs in basophils. Nat Immunol. 2009;10:889–98.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Brandtzaeg P, Nilssen DE. Mucosal aspects of primary B cell deficiency and gastrointestinal infections. Curr Opin Gastroenterol. 1995;11:532–40.

    Article  CAS  Google Scholar 

  13. Finkelman FD, van Boxel JA, Asofsky R, Paul WE. Cell membrane IgD: demonstration of IgD on human lymphocytes by enzyme-catalyzed iodination and comparison with cell surface Ig of mouse, guinea pig, and rabbit. J Immunol. 1976;116:1173–81.

    CAS  PubMed  Google Scholar 

  14. Kerr WG, Hendershot LM, Burrows PD. Regulation of IgM and IgD expression in human B-lineage cells. J Immunol. 1991;146:3314–21.

    CAS  PubMed  Google Scholar 

  15. Dunnette SL, Gleich GJ, Miller RD, Kyle RA. Measurement of IgD by a double antibody radioimmunoassay: demonstration of an apparent trimodal distribution of IgD levels in normal human sera. J Immunol. 1977;119:1727–31.

    CAS  PubMed  Google Scholar 

  16. Bahna SL, Heiner DC, Myhre BA. Changes in serum IgD in cigarette smokers. Clin Exp Immunol. 1983;51:624–30.

    CAS  PubMed  PubMed Central  Google Scholar 

  17. Chen K, Cerutti A. New insights into the enigma of immunoglobulin D. Immunol Rev. 2010;237:160–79.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. Rowe DS, Crabbe PA, Turner MW. Immunoglobulin D in serum, body fluids and lymphoid tissues. Clin Exp Immunol. 1968;3:477–90.

    CAS  PubMed  PubMed Central  Google Scholar 

  19. Cederqvist LL, Ewool LC, Bonsnes RW, Litwin SD. Detectability and pattern of immunoglobulins in normal amniotic fluid throughout gestation. Am J Obstet Gynecol. 1978;130:220–4.

    CAS  PubMed  Google Scholar 

  20. Brandtzaeg P, Bjerke K, Kett K, Kvale D, Rognum TO, Scott H, Sollid LM, Valnes K. Production and secretion of immunoglobulins in the gastrointestinal tract. Ann Allergy. 1987;59:21–39.

    CAS  PubMed  Google Scholar 

  21. Dvorak AM, Seder RA, Paul WE, Kissell-Rainville S, Plaut M, Galli SJ. Ultrastructural characteristics of Fc epsilon R-positive basophils in the spleen and bone marrow of mice immunized with goat anti-mouse IgD antibody. Lab Invest. 1993;68:708–15.

    CAS  PubMed  Google Scholar 

  22. Luster MI, Armen RC, Hallum JV, Leslie GA. Measles virus-specific IgD antibodies in patients with subacute sclerosing panencephalitis. Proc Natl Acad Sci USA. 1976;73:1297–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  23. Sewell HF, Chambers L, Maxwell V, Matthews JB, Jefferis R. The natural antibody response to E. coli includes antibodies of the IgD class. Clin Exp Immunol. 1978;31:104–10.

    CAS  PubMed  PubMed Central  Google Scholar 

  24. Forsgren A, Brant M, Möllenkvist A, Muyombwe A, Janson H, Woin N, Riesbeck K. Isolation and characterization of a novel IgD-binding protein from Moraxella catarrhalis. J Immunol. 2001;167:2112–20.

    Article  CAS  PubMed  Google Scholar 

  25. Litzman J, Ward AM, Wild G, Znojil V, Morgan G. Serum IgD levels in children under investigation for and with defined immunodeficiency. Int Arch Allergy Immunol. 1997;114:54–8.

    Article  CAS  PubMed  Google Scholar 

  26. Mizuma H, Zolla-Pazner S, Litwin S, el-Sadr W, Sharpe S, Zehr B, Weiss S, Saxinger WC, Marmor M. Serum IgD elevation is an early marker of B cell activation during infection with the human immunodeficiency viruses. Clin Exp Immunol. 1987;68:5–14.

    CAS  PubMed  PubMed Central  Google Scholar 

  27. Rostenberg I, Penaloza R. Serum IgG and IgD and levels in some infectious and noninfectious diseases. Clin Chim Acta. 1978;85:319–21.

    Article  CAS  PubMed  Google Scholar 

  28. Kikindjanin V. IgD values in children suffering from acute, recurrent and chronic respiratory diseases. Allerg Immunol (Leipz). 1981;27:203–6.

    CAS  Google Scholar 

  29. Buckley CE, Trayer HR. Serum IgD concentrations in sarcoidosis and tuberculosis. Clin Exp Immunol. 1972;10:257–65.

    CAS  PubMed  PubMed Central  Google Scholar 

  30. Sirisinha S, Charupatana C, Ramasoota T. Serum immunoglobulins in leprosy patients with different spectra of clinical manifestations. Proc Soc Exp Biol Med. 1972;140:1062–8.

    Article  CAS  PubMed  Google Scholar 

  31. Blade J, Lust JA, Kyle RA. Immunoglobulin D multiple myeloma: presenting features, response to therapy, and survival in a series of 53 cases. J Clin Oncol. 1994;12:2398–404.

    CAS  PubMed  Google Scholar 

  32. Golomb HM, Davis S, Wilson C, Vardiman J. Surface immunoglobulins on hairy cells of 55 patients with hairy cell leukemia. Am J Hematol. 1982;12:397–401.

    Article  CAS  PubMed  Google Scholar 

  33. Peng Z, Fisher R, Adkinson NF Jr. Total serum IgD is increased in atopic subjects. Allergy. 1991;46:436–44.

    Article  CAS  PubMed  Google Scholar 

  34. Najam FI, Giasuddin AS, Shembesh AH. Immunoglobulin isotypes in childhood asthma. Indian J Pediatr. 1999;66:337–44.

    Article  CAS  PubMed  Google Scholar 

  35. Zhang M, Niehus J, Brunnee T, Kleine-Tebbe J, O’Connor A, Kunkel G. Measurement of allergen-specific IgD and correlation with allergen-specific IgE. Scand J Immunol. 1994;40:502–8.

    Article  CAS  PubMed  Google Scholar 

  36. Koelsch K, Zheng NY, Zhang Q, Duty A, Helms C, Mathias MD, Jared M, Smith K, Capra JD, Wilson PC. Mature B cells class switched to IgD are autoreactive in healthy individuals. J Clin Invest. 2007;117:1558–65.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  37. Pope RM, Keightley R, McDuffy S. Circulating autoantibodies to IgD in rheumatic diseases. J Immunol. 1982;128:1860–3.

    CAS  PubMed  Google Scholar 

  38. Rigante D, Frediani B, Galeazzi M, Cantarini L. From the Mediterranean to the sea of Japan: the transcontinental odyssey of autoinflammatory diseases. Biomed Res Int. 2013;2013:485103.

    Article  PubMed  PubMed Central  Google Scholar 

  39. Rigante D. The protean visage of systemic autoinflammatory syndromes: a challenge for inter-professional collaboration. Eur Rev Med Pharmacol Sci. 2010;14:1–18.

    CAS  PubMed  Google Scholar 

  40. Cantarini L, Rigante D, Brizi MG, Lucherini OM, Sebastiani GD, Vitale A, Gianneramo V, Galeazzi M. Clinical and biochemical landmarks in systemic autoinflammatory diseases. Ann Med. 2012;44:664–73.

    Article  PubMed  Google Scholar 

  41. Esposito S, Ascolese B, Senatore L, Bosis S, Verrecchia E, Cantarini L, Rigante D. Current advances in the understanding and treatment of mevalonate kinase deficiency. Int J Immunopathol Pharmacol. 2014;27:491–8.

    CAS  PubMed  Google Scholar 

  42. Rigante D, Vitale A, Lucherini OM, Cantarini L. The hereditary autoinflammatory disorders uncovered. Autoimmun Rev. 2014;13:892–900.

    Article  CAS  PubMed  Google Scholar 

  43. Stabile A, Bertoni B, Ansuini V, La Torraca I, Salli A, Rigante D. The clinical spectrum and treatment options of macrophage activation syndrome in the pediatric age. Eur Rev Med Pharmacol Sci. 2006;10:53–9.

    CAS  PubMed  Google Scholar 

  44. Rigante D, Emmi G, Fastiggi M, Silvestri E, Cantarini L. Macrophage activation syndrome in the course of monogenic autoinflammatory disorders. Clin Rheumatol. 2015;34:333–9.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Pediatrics, Fondazione Policlinico Universitario Agostino Gemelli, Università Cattolica Sacro Cuore, Rome, Italy

    Donato Rigante

Authors
  1. Donato Rigante
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Donato Rigante.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Rigante, D. The truth on IgD in the ploy of immune surveillance and inflammation. Immunol Res 64, 632–635 (2016). https://doi.org/10.1007/s12026-015-8744-z

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12026-015-8744-z

Keywords

Search

Navigation