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Immunological function of Blimp-1 in dendritic cells and relevance to autoimmune diseases

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Abstract

Previous studies have identified the immunological functions of transcription factor B lymphocyte-induced maturation protein-1 (Blimp-1) in various adaptive immune cell types such as T and B lymphocytes. More recently, it has been shown that Blimp-1 extends its functional roles to dendritic cells (DCs) and macrophages, two cell types belonging to the innate immune system. The protein acts as a direct and indirect regulator of target genes by recruiting chromatin modification factors and by regulating microRNA expression, respectively. In DCs, Blimp-1 has been identified as one of the components involved in antigen presentation. Genome-wide association studies identified polymorphisms associated with multiple autoimmune diseases such as system lupus erythematosus, rheumatoid arthritis, and inflammatory bowel disease in PRDM1, the gene encoding Blimp-1 protein. In this review, we will discuss the immune regulatory functions of Blimp-1 in DCs with a main focus on the tolerogenic mechanisms of Blimp-1 required to protect against the development of autoimmune diseases.

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Acknowledgments

The author wish to thank Dr. Betty Diamond for providing support and scientific criticisms throughout the project, Dr. Gregersen for guidance for human genetics and human samples, and Sylvia Jones for helping the manuscript. SJ Kim is supported by R01 AR065209 and K01 AR59378. Author has no conflict of interest to declare.

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  1. Center for Autoimmune and Musculoskeletal Disease, The Feinstein Institute for Medical Research, Manhasset, NY, 11030, USA

    Sun Jung Kim

  2. Department of Molecular Medicine, Hofstra-North Shore LIJ School of Medicine, Hempstead, NY, USA

    Sun Jung Kim

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Kim, S.J. Immunological function of Blimp-1 in dendritic cells and relevance to autoimmune diseases. Immunol Res 63, 113–120 (2015). https://doi.org/10.1007/s12026-015-8694-5

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