Article

Immunologic Research

, Volume 47, Issue 1, pp 25-44

Mechanisms involved in antibody- and complement-mediated allograft rejection

  • Barbara A. WasowskaAffiliated withDepartment of Pathology, The Johns Hopkins University School of Medicine Email author 

Rent the article at a discount

Rent now

* Final gross prices may vary according to local VAT.

Get Access

Abstract

Antibody-mediated rejection has become critical clinically because this form of rejection is usually unresponsive to conventional anti-rejection therapy, and therefore, it has been recognized as a major cause of allograft loss. Our group developed experimental animal models of vascularized organ transplantation to study pathogenesis of antibody- and complement-mediated endothelial cell injury leading to graft rejection. In this review, we discuss mechanisms of antibody-mediated graft rejection resulting from activation of complement by C1q- and MBL (mannose-binding lectin)-dependent pathways and interactions with a variety of effector cells, including macrophages and monocytes through Fcγ receptors and complement receptors.

Keywords

Alloantibody Complement Ig knockout mice Cardiac rejection vWf C4d MBL Fcγ and complement receptors Endothelial cells Macrophages