Immunologic Research

, Volume 47, Issue 1, pp 25–44

Mechanisms involved in antibody- and complement-mediated allograft rejection


DOI: 10.1007/s12026-009-8136-3

Cite this article as:
Wasowska, B.A. Immunol Res (2010) 47: 25. doi:10.1007/s12026-009-8136-3


Antibody-mediated rejection has become critical clinically because this form of rejection is usually unresponsive to conventional anti-rejection therapy, and therefore, it has been recognized as a major cause of allograft loss. Our group developed experimental animal models of vascularized organ transplantation to study pathogenesis of antibody- and complement-mediated endothelial cell injury leading to graft rejection. In this review, we discuss mechanisms of antibody-mediated graft rejection resulting from activation of complement by C1q- and MBL (mannose-binding lectin)-dependent pathways and interactions with a variety of effector cells, including macrophages and monocytes through Fcγ receptors and complement receptors.


AlloantibodyComplementIg knockout miceCardiac rejectionvWfC4dMBLFcγ and complement receptorsEndothelial cellsMacrophages

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© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Department of PathologyThe Johns Hopkins University School of MedicineBaltimoreUSA