DNA Review

Forensic Science, Medicine, and Pathology

, 4:129

First online:

DNA reviews: low level DNA profiling

  • Eleanor A. M. GrahamAffiliated withEast Midlands Forensic Pathology Unit, University of Leicester Email author 

Rent the article at a discount

Rent now

* Final gross prices may vary according to local VAT.

Get Access


Low copy number (LCN) DNA profiling has recently been scrutinized in the United Kingdom following the comments of Mr Justice Weir made during the trial of suspected terrorist Sean Hoey. Mr Hoey was acquitted of all charges related to the Omagh bombing of 1998, following the inadmissibility of key DNA evidence during this trial. The Association of Chief Police Officers and Crown Prosecution Service, initially suspended the use of this technique, but quickly reinstated its use following an internal enquiry. This review describes the low copy number technique and the sample types that are now routinely collected from suspects, victims, and crime scenes for examination by this method.


Forensic DNA transfer Low copy number (LCN) Touch DNA Stochastic effects