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Increasing Diagnosis of Thyroid Papillary Carcinoma Follicular Variant in South-East Anatolian Region: Comparison of Characteristics of Classical Papillary and Follicular Variant Thyroid Cancers

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Abstract

We aimed to compare ratios of thyroid cancers diagnosed in our regional reference hospital Pathology Center in Sanliurfa city located in southeast Anatolia, and evaluate the characteristics related with follicular variant papillary thyroid carcinoma (FVPTC). We re-evaluated the specimens of last 5 years thyroidectomies by same five pathologists, by same criteria and immunohistochemical evaluation. Chi-square test was used to compare characteristics of classical pure papillary thyroid carcinomas and FVPTC groups. Stepwise multiple regression analysis was used to evaluate the factors related with presence of FVPTC. Among 400 thyroidectomies, there were 105 papillary thyroid carcinoma, 42 of them with pure PTC, and 56 with FVPC, also seven with other variants. There was increase in ratios of FVPTC/PTC between 2010 and 2011 (68.4 vs 76.7 %, p < 0.005). Radius, vascular invasion, and extrathyroidal invasion showed statistically significant difference between pure PTC and FVPTC. In regression analysis radius (p = 0.001, OR = 2.611; 95 %CI, 2.010–3.391), age (p = 0.018, OR = 0.959; 95 %CI, 0.927–0.993), and multicentricity (p = 0.044, OR = 0.403; 95 %CI, 0.167–0.975) were related with presence of FVPTC. Besides, further need for studies to understand whether total prevalence of FVPTC is higher in this region, and the related factors, our study showed that the ratio of FVPTC/PTC is higher in our reference hospital. Age of the patients and the radius and multicentricity of the nodules could be alarming factors for us to suspect for FVPTC.

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Acknowledgments

We would like to thank to Dr. Zeynep Tarini, Dr. Sezen Koçarslan, Dr. Dilek Mil, and the Şanlıurfa Education and Research Hospital Pathology and General Surgery Department staffs and doctors for their help during the study.

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Authors and Affiliations

  1. Endocrinology and Metabolic Diseases Department, Turkish Ministry of Health, Şanlıurfa Education and Research Hospital, Esentepe, 63100, Şanlıurfa, Turkey

    Sibel Ertek

  2. Pathology Department, Turkish Ministry of Health, Şanlıurfa Education and Research Hospital, Şanlıurfa, Turkey

    Nuray Can Yılmaz, Özgül Vurupalmaz & Ahu Senem Demiröz

  3. Department of Internal Medicine, Aging and Kidney Diseases, Bologna University, Bologna, Italy

    Arrigo F. Cicero

  4. Endocrinology and Metabolic Diseases Department, Ufuk University Medical Faculty, Ankara, Turkey

    Gürbüz Erdoğan

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  1. Sibel Ertek
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  2. Nuray Can Yılmaz
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  3. Arrigo F. Cicero
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  4. Özgül Vurupalmaz
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  5. Ahu Senem Demiröz
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  6. Gürbüz Erdoğan
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Correspondence to Sibel Ertek.

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Ertek, S., Yılmaz, N.C., Cicero, A.F. et al. Increasing Diagnosis of Thyroid Papillary Carcinoma Follicular Variant in South-East Anatolian Region: Comparison of Characteristics of Classical Papillary and Follicular Variant Thyroid Cancers. Endocr Pathol 23, 157–160 (2012). https://doi.org/10.1007/s12022-012-9216-9

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  • DOI: https://doi.org/10.1007/s12022-012-9216-9

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