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Correlation of high urinary Smad1 level with glomerular hyperfiltration in type 2 diabetes mellitus

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Abstract

The aim of this study was to assess the relationship between urinary Smad1 and glomerular hyperfiltration (GHF) in type 2 diabetes mellitus (T2DM), and to explore the factors related to the urinary Smad1 in T2DM. The reference value of the estimated glomerular filtration rate (eGFR) was determined in 248 healthy individuals. 30 patients with GHF, 58 patients with norm-GFR T2DM, and 24 healthy patients who served as controls were recruited. Urinary Smad1, fasting plasma glucose (FPG), fasting serum C-Peptide (C-P), hemoglobin A1C (HbA1c), cystatin C, and other chemistry laboratory parameters of T2DM participants and controls were measured. Patients with GHF had higher levels of urinary Smad1 than the control group, and those with norm-GFR. For T2DM patients with body mass index, age, and gender adjustments, urinary Smad1 was positively correlated with FPG, HbA1C, and eGFR, but negatively correlated with fasting serum C-P. Multivariate linear regression analysis demonstrated that eGFR, HbA1C, and fasting serum C-P were independently associated with urinary Smad1. High levels of urinary Smad1 were found in GHF patients with T2DM, which may be another potential mechanism of GHF in relation to diabetic nephropathy.

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Acknowledgments

This study was supported by the funds from the Scientific and Technological Projects of Dongguan City, Guangdong Province, People’s Republic of China.

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Authors and Affiliations

  1. Department of Laboratory, Affiliated Houjie Hospital, Guangdong Medical College, 523945, Dongguan, China

    Wen-Jin Fu, Yao-Gao Fang, Ren-Tang Deng, Mei-Lian Chen, Zhi-Hong Huang & Hui-Hua Tang

  2. Department of Obstetrics and Gynecology, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, 77030, USA

    Shu Wen

  3. Department of Laboratory Medicine Centre, Southern Medical University, Guangzhou, 510515, Guangdong, China

    Shi-Long Xiong & Qian Wang

  4. Department of Laboratory Medicine, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, 510120, People’s Republic of China

    Xian-Zhang Huang

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  1. Wen-Jin Fu
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Corresponding authors

Correspondence to Xian-Zhang Huang or Qian Wang.

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Fu, WJ., Fang, YG., Deng, RT. et al. Correlation of high urinary Smad1 level with glomerular hyperfiltration in type 2 diabetes mellitus. Endocrine 43, 346–350 (2013). https://doi.org/10.1007/s12020-012-9741-9

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  • DOI: https://doi.org/10.1007/s12020-012-9741-9

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