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Targeting MicroRNAs Involved in the BDNF Signaling Impairment in Neurodegenerative Diseases

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Abstract

Neurodegenerative diseases are becoming an ever-increasing problem in aging populations. Low levels of brain-derived neurotrophic factor (BDNF) have previously been associated with the pathogenesis of numerous neurodegenerative diseases. Recently, microRNAs (miRNAs) have been proposed as potential novel therapeutic targets for treating various diseases of the central nervous system (CNS), and interestingly, few studies have reported several miRNAs that downregulate the expression levels of BDNF. However, substantial challenges exist when attempting to translate these findings into practical anti-miRNA therapeutics, especially when the targets remain inside the CNS. Thus, in this review, we summarize the specific molecular mechanisms by which several miRNAs negatively modulate the expressions of BDNF, address the potential clinical difficulties that can be faced during the development of anti-miRNA-based therapeutics and propose strategies to overcome these challenges.

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    Authors and Affiliations

    1. Yonsei University, College of Medicine, Seoul, Korea

      Hwa Jeong You & Jae Hyon Park

    2. European University of Madrid, Madrid, Spain

      Helios Pareja-Galeano & Alejandro Lucia

    3. Research Institute of Hospital 12 de Octubre (‘i+12′), Madrid, Spain

      Helios Pareja-Galeano & Alejandro Lucia

    4. Department of Pediatrics, Yonsei University College of Medicine, Yonsei-Ro 50, Seodaemun-Gu, C.P.O. Box 8044, Seoul, 120-752, Korea

      Jae Il Shin

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    Hwa Jeong You and Jae Hyon Park have contributed equally to this work.

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    You, H.J., Park, J.H., Pareja-Galeano, H. et al. Targeting MicroRNAs Involved in the BDNF Signaling Impairment in Neurodegenerative Diseases. Neuromol Med 18, 540–550 (2016). https://doi.org/10.1007/s12017-016-8407-9

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