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Biological Modulators in Eosinophilic Diseases

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Abstract

Eosinophils can regulate local and systemic inflammation, and their presence in higher numbers appears to play an important role in the pathology of various atopic and inflammatory diseases. Eosinophil maturation, recruitment, and survival depend on several cytokine regulators, including interleukin (IL)-5, IL-4, and IL-13 as well as growth factors such as GM-CSF. Over the last decade, the approach to treating eosinophilic diseases has changed greatly. A number of biologic modulators have been developed to target eosinophilic inflammatory pathways, and their usage has resulted in variable clinical improvement in the treatment of eosinophilic-associated conditions. Novel targeted therapies that are safe and effective for treating these disorders are being investigated. This review summarizes the clinical use of biologic agents that have been studied in clinical trials or approved for treating eosinophilic diseases.

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Abbreviations

mAb:

Monoclonal antibody

HES:

Hypereosinophilic syndrome

CHR:

Complete hematologic response

CMR:

Complete molecular response

CSS:

Churg-Strauss syndrome

EGPA:

Eosinophilic granulomatosis with polyangiitis

NP:

Nasal polyposis

EOE:

Eosinophilic esophagitis

CRTH2:

Chemoattractant receptor homologous molecule expressed on Th2 cells

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Acknowledgments

We thank Dr. Jane Carver for reviewing this manuscript.

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Panida Sriaroon and Mark Ballow declare that they have no conflict of interest relevant to the topic discussed in this article.

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  1. Division of Allergy, Immunology, and Rheumatology, Department of Pediatrics, University of South Florida, 140 7th ave S, CRI 4008, St. Petersburg, FL, 33701, USA

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Sriaroon, P., Ballow, M. Biological Modulators in Eosinophilic Diseases. Clinic Rev Allerg Immunol 50, 252–272 (2016). https://doi.org/10.1007/s12016-014-8444-9

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