Clinical Reviews in Allergy & Immunology

, Volume 41, Issue 3, pp 237–244

Pruritus and Atopic Dermatitis

Authors

    • Department of Dermatology and Allergy BiedersteinTechnische Universität München
    • Division of Environmental Dermatology and Allergy GSF/TUM
    • Christine Kühne Center for Allergy Research and Education (CK-CARE)
    • Klinik und Poliklinik für Dermatologie und Allergologie am BiedersteinTechnische Universität München
  • Florian Pfab
    • Department of Dermatology and Allergy BiedersteinTechnische Universität München
    • Division of Environmental Dermatology and Allergy GSF/TUM
    • Christine Kühne Center for Allergy Research and Education (CK-CARE)
  • Michael Valet
    • Department of NeurologyTechnische Universität München
  • Johannes Huss-Marp
    • Division of Environmental Dermatology and Allergy GSF/TUM
  • Heidrun Behrendt
    • Division of Environmental Dermatology and Allergy GSF/TUM
    • Christine Kühne Center for Allergy Research and Education (CK-CARE)
  • Johannes Ring
    • Department of Dermatology and Allergy BiedersteinTechnische Universität München
    • Christine Kühne Center for Allergy Research and Education (CK-CARE)
  • Sonja Ständer
    • Department of Dermatology, Competence Center PruritusUniversity of Münster
Article

DOI: 10.1007/s12016-010-8230-2

Cite this article as:
Darsow, U., Pfab, F., Valet, M. et al. Clinic Rev Allerg Immunol (2011) 41: 237. doi:10.1007/s12016-010-8230-2

Abstract

Atopic eczema is one of the most pruritic skin diseases. Mediators of atopic eczema itch in the skin are still mostly unknown, but recent studies showed that the histamine 4 receptor plays an important role in itch pathophysiology; tryptase and interleukin-31 are also involved. Differences in itch perception and itch kinetics between healthy volunteers and eczema patients point towards an ongoing central nervous inhibitory activity in patients. Questionnaire studies reported comparatively higher loads in affective items chosen by patients with atopic eczema. In the concept of patient management, the therapy of clinical pruritus has to consider origin and perception of itch, namely the skin and the central nervous system, by combining topical and systemic treatment.

Keywords

Atopic dermatitis Eczema Itch Antipruritic treatment

Copyright information

© Springer Science+Business Media, LLC 2010