Article

Clinical Reviews in Allergy & Immunology

, Volume 41, Issue 3, pp 237-244

Pruritus and Atopic Dermatitis

  • Ulf DarsowAffiliated withDepartment of Dermatology and Allergy Biederstein, Technische Universität MünchenDivision of Environmental Dermatology and Allergy GSF/TUMChristine Kühne Center for Allergy Research and Education (CK-CARE)Klinik und Poliklinik für Dermatologie und Allergologie am Biederstein, Technische Universität München Email author 
  • , Florian PfabAffiliated withDepartment of Dermatology and Allergy Biederstein, Technische Universität MünchenDivision of Environmental Dermatology and Allergy GSF/TUMChristine Kühne Center for Allergy Research and Education (CK-CARE)
  • , Michael ValetAffiliated withDepartment of Neurology, Technische Universität München
  • , Johannes Huss-MarpAffiliated withDivision of Environmental Dermatology and Allergy GSF/TUM
  • , Heidrun BehrendtAffiliated withDivision of Environmental Dermatology and Allergy GSF/TUMChristine Kühne Center for Allergy Research and Education (CK-CARE)
  • , Johannes RingAffiliated withDepartment of Dermatology and Allergy Biederstein, Technische Universität MünchenChristine Kühne Center for Allergy Research and Education (CK-CARE)
  • , Sonja StänderAffiliated withDepartment of Dermatology, Competence Center Pruritus, University of Münster

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Abstract

Atopic eczema is one of the most pruritic skin diseases. Mediators of atopic eczema itch in the skin are still mostly unknown, but recent studies showed that the histamine 4 receptor plays an important role in itch pathophysiology; tryptase and interleukin-31 are also involved. Differences in itch perception and itch kinetics between healthy volunteers and eczema patients point towards an ongoing central nervous inhibitory activity in patients. Questionnaire studies reported comparatively higher loads in affective items chosen by patients with atopic eczema. In the concept of patient management, the therapy of clinical pruritus has to consider origin and perception of itch, namely the skin and the central nervous system, by combining topical and systemic treatment.

Keywords

Atopic dermatitis Eczema Itch Antipruritic treatment