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Advances in Mesenchymal Stem Cell-based Strategies for Cartilage Repair and Regeneration

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Abstract

Significant research efforts have been undertaken in the last decade in the development of stem cell-based therapies for cartilage repair. Among the various stem cell sources, mesenchymal stem cells (MSCs) demonstrate great promise and clinical efficacy in cartilage regeneration. With a deeper understanding of stem cell biology, new therapeutics and new bioengineering approaches have emerged and showed potential for further developments. Of note, there has been a paradigm shift in applying MSCs for tissue regeneration from the use of stem cells for transplantation to the use of stem cell-derived matrix and secretome components as therapeutic tools and agents for cartilage regeneration. In this review, we will discuss the emerging role of MSCs in cartilage regeneration and the most recent advances in development of stem cell-based therapeutics for cartilage regeneration.

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Acknowledgments

This work was partially supported by grants (R221000068720 and R221000070733) from National University of Singapore, National University Healthcare System, and Ministry of Education, Singapore.

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The authors indicate no potential conflicts of interest.

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Authors and Affiliations

  1. Faculty of Dentistry, National University of Singapore, 11 Lower Kent Ridge Road, Singapore, 119083, Singapore

    Wei Seong Toh

  2. Tissue Engineering Program, Life Sciences Institute, National University of Singapore, 27 Medical Drive, Singapore, 117510, Singapore

    Wei Seong Toh & James Hoi Po Hui

  3. Orthopaedic Research Laboratory, Aarhus University Hospital, Noerrebrogade 44, building 1A, 8000, Aarhus C, Denmark

    Casper Bindzus Foldager

  4. Stem Cell and Tissue Engineering Laboratory, Department of Orthopaedics, West Virginia University, One Medical Center Drive, PO Box 9196, Morgantown, WV, 26506-9196, USA

    Ming Pei

  5. Cartilage Repair Program, Therapeutic Tissue Engineering Laboratory, Department of Orthopaedic Surgery, National University Health System, National University of Singapore, 1E Kent Ridge Road, Singapore, 119288, Singapore

    James Hoi Po Hui

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  1. Wei Seong Toh
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  2. Casper Bindzus Foldager
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Correspondence to Wei Seong Toh.

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Toh, W.S., Foldager, C.B., Pei, M. et al. Advances in Mesenchymal Stem Cell-based Strategies for Cartilage Repair and Regeneration. Stem Cell Rev and Rep 10, 686–696 (2014). https://doi.org/10.1007/s12015-014-9526-z

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