Stem Cell Reviews and Reports

, Volume 9, Issue 3, pp 326–338

Cardiac Stem Cells and their Roles in Myocardial Infarction

  • Jingying Hou
  • Lingyun Wang
  • Jieyu Jiang
  • Changqing Zhou
  • Tianzhu Guo
  • Shaoxin Zheng
  • Tong Wang
Article

DOI: 10.1007/s12015-012-9421-4

Cite this article as:
Hou, J., Wang, L., Jiang, J. et al. Stem Cell Rev and Rep (2013) 9: 326. doi:10.1007/s12015-012-9421-4

Abstract

Myocardial infarction leads to loss of cardiomyocytes, scar formation, ventricular remodeling and eventually deterioration of heart function. Over the past decade, stem cell therapy has emerged as a novel strategy for patients with ischemic heart disease and its beneficial effects have been demonstrated by substantial preclinical and clinical studies. Efficacy of several types of stem cells in the therapy of cardiovascular diseases has already been evaluated. However, repair of injured myocardium through stem cell transplantation is restricted by critical safety issues and ethic concerns. Recently, the discovery of cardiac stem cells (CSCs) that reside in the heart itself brings new prospects for myocardial regeneration and reconstitution of cardiac tissues. CSCs are positive for various stem cell markers and have the potential of self-renewal and multilineage differentiation. They play a pivotal role in the maintenance of heart homeostasis and cardiac repair. Elucidation of their biological characteristics and functions they exert in myocardial infarction are very crucial to further investigations on them. This review will focus on the field of cardiac stem cells and discuss technical and practical issues that may involve in their clinical applications in myocardial infarction.

Keywords

Cardiac stem cellsMyocardial infarctionCell therapyMyocardial regenerationCardiac repair

Abbreviations

CSCs

Cardiac stem cells

MI

Myocardial infarction

CPCs

Cardiac progenitor cells

ESCs

Embryonic stem cells

BMSCs

Bone marrow stem cells

iPSCs

Induced pluripotent stem cells

EPCs

Embryo progenitor cells

BMPCs

Bone marrow progenitors cells

SP

Side population

LV

Left ventricular

mCSCs

Myogenic CSCs

vCSCs

Vasculogenic CSCs

IGF-1

Insulin-like growth factor 1

HGF

Hepatocyte growth factor

SDF-1

Stromal cell-derived factor-1

VEGF

Vascular endothelial growth factor

TGF-β

Transforming growth factor beta

BMP

Bone morphogenetic protein

Copyright information

© Springer Science+Business Media New York 2012

Authors and Affiliations

  • Jingying Hou
    • 1
  • Lingyun Wang
    • 2
  • Jieyu Jiang
    • 1
  • Changqing Zhou
    • 1
  • Tianzhu Guo
    • 1
  • Shaoxin Zheng
    • 3
  • Tong Wang
    • 1
    • 4
  1. 1.Department of EmergencyThe Sun Yat-sen Memorial Hospital of Sun Yat-sen UniversityGuangzhouChina
  2. 2.Department of GastroenterologyThe Sun Yat-sen Memorial Hospital of Sun Yat-sen UniversityGuangzhouChina
  3. 3.Department of CardiologyThe Sun Yat-sen Memorial Hospital of Sun Yat-sen UniversityGuangzhouChina
  4. 4.Center for Stem Cell Biology and Tissue Engineering, Ministry of EducationSun Yat-sen UniversityGuangzhouChina