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Comparison Between Sporadic and Misdiagnosed Sporadic Creutzfeldt–Jakob Disease: A Report of Two Cases

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Abstract

Definite accurate diagnosis for Creutzfeldt–Jakob disease (CJD) depends on neuropathologic examination of brain biopsy or autopsy. However, transmissible nature makes the invasive examination dangerous. This study was set to determine that the clinical features are for the diagnosis of CJD through a comparison study. We compared clinical features of two cases with initial diagnosis of sporadic CJD. One case was finally diagnosed as definite sporadic CJD. According to World Health Organization diagnosis criteria, the other one, which had been diagnosed as probable sporadic CJD, was confirmed as limbic encephalitis after long-term follow-up. Compared with the case of definite sporadic CJD, the misdiagnosed case did not present typical electroencephalogram (EEG) and diffusion-weighted in magnetic resonance images (DWI) of CJD. However, cerebrospinal fluid in the misdiagnosed patient showed 14-3-3 protein positivity. The patient conditions improved after treatment. Through this case comparison, we conclude that EEG and DWI are necessary for accurate diagnosis of sporadic CJD. Further, long-term follow-up is crucial to diagnosis and treatment of CJD.

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    Authors and Affiliations

    1. Department of Neurology, Yan An University Xianyang Hospital, Wenlin Road, Xianyang, 712000, China

      Xiongfei Zhao, Zhiru Zhao & Jiaping Xu

    2. Department of Neurology, Navy General Hospital, Beijing, 100048, China

      Yingxin Yu

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    1. Xiongfei Zhao
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    2. Yingxin Yu
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    3. Zhiru Zhao
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    4. Jiaping Xu
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    Correspondence to Xiongfei Zhao.

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    Xiongfei Zhao and Yingxin Yu contributed to this manuscript equally as first authors.

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    Zhao, X., Yu, Y., Zhao, Z. et al. Comparison Between Sporadic and Misdiagnosed Sporadic Creutzfeldt–Jakob Disease: A Report of Two Cases. Cell Biochem Biophys 72, 311–315 (2015). https://doi.org/10.1007/s12013-014-0458-7

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    • DOI: https://doi.org/10.1007/s12013-014-0458-7

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