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Evaluation of the Association Between CD143 Gene Polymorphism and Psoriasis

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Abstract

Increased CD143 activity has been detected in various skin tissues, and this increase is partially caused by the intronic ID polymorphism. The genetic contribution of CD143 ID polymorphism to the progression of psoriasis, the commonest skin disease, has been extensively investigated, but reported with inconsistent results. The aim of this work was to gain new insights to shed light on the association between CD143 ID polymorphism and psoriasis risk. We systematically identified the studies examining the association of CD143 ID polymorphism with psoriasis risk. A meta-analysis combining data from all eligible studies was carried out. To evaluate the genetic association, we calculated odds ratio (OR) and its 95 % confidence intervals (CIs) for both genotypic models and allelic model. The final pooling dataset comprised ten studies. Meta-analysis of total samples did not suggest a notable association with psoriasis risk. However, subgroup analysis by ethnicity revealed a statistically significant association in East Asian samples (DD + ID vs. II: OR 0.86, 95 % CI 0.75–0.99, Pheterogeneity = 0.970; DD vs. ID: OR 0.85, 95 % CI 0.73–0.99, Pheterogeneity = 0.868; D vs. I: OR 0.86, 95 % CI 0.76–0.97, Pheterogeneity = 0.994). This meta-analysis demonstrated that the presence of CD143 ID polymorphism may modify the risk of psoriasis in individuals with East Asian ancestry.

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Authors and Affiliations

  1. Chinese PLA General Hospital, Beijing, China

    Tianbao Xia

  2. Department of Dermatology, 306 Hospital of PLA, Beijing, China

    Tianbao Xia & Shichao Lv

  3. Department of Neuro-Oncology Surgery, The General Hospital of Chinese People’s Armed Police Forces, Beijing, China

    Jinfu Diao

  4. Department of Intensive Care Medicine, Jinan Military General Hospital, Jinan, China

    He Huang

  5. Department of Health, Management Security Department of General Staff, PLA, Beijing, China

    Jie Li

  6. Department of Stomatology, 306 Hospital of PLA, Beijing, China

    Lei Sun

  7. Department of Dermatology, Chinese PLA General Hospital, Beijing, China

    Hengjin Li

Authors
  1. Tianbao Xia
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  2. Jinfu Diao
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  3. He Huang
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  4. Jie Li
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  7. Shichao Lv
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Corresponding authors

Correspondence to Hengjin Li or Shichao Lv.

Additional information

Tianbao Xia and Jinfu Diao have contributed equally to this study.

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Xia, T., Diao, J., Huang, H. et al. Evaluation of the Association Between CD143 Gene Polymorphism and Psoriasis. Cell Biochem Biophys 70, 1617–1623 (2014). https://doi.org/10.1007/s12013-014-0104-4

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  • DOI: https://doi.org/10.1007/s12013-014-0104-4

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