Skip to main content
SpringerLink
Log in

Questionable Conclusions in the Article “Cardiovascular Toxicity of Citrus aurantium in Exercised Rats”

  • Published:
Cardiovascular Toxicology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Hansen, D. K., George, N. I., White, G. E., Abdel-Rahman, A., Pellicore, L. S., & Fabricant, D. (2013). Cardiotoxicity of Citrus aurantium in exercised rats. Cardiovascular Toxicity,. doi:10.1007/s12012-013-9199-x12pages.

    Google Scholar 

  2. Stohs, S. J. (2010). A review and assessment of the FDA adverse events reports and clinical case reports associated with bitter orange (Citrus aurantium) between April 2004 and October 2009. Journal of Functional Foods, 2, 235–238.

    Article  Google Scholar 

  3. Stohs, S. J., & Preuss, H. G. (2011). The safety of bitter orange (Citrus aurantium) and p-synephrine. HerbalGram, 89, 34–39.

    Google Scholar 

  4. Stohs, S. J., Preuss, H. G., & Shara, M. (2011). The safety of Citrus aurantium (bitter orange) and its primary protoalkaloid p-synephrine. Phytotherapy Research, 25, 1421–1428.

    Article  CAS  PubMed  Google Scholar 

  5. Stohs, S.J, Shara, M. (2012). A review of the safety and efficacy of Citrus aurantium in weight management. In: Obesity: Epidemiology, Pathophysiology and Prevention, 2nd Ed. D. Bagchi and H. Preuss, Ed. CRC Press. pp. 535-554.

  6. Stohs, S. J., Preuss, H. G., & Shara, M. (2012). A review of the human clinical studies of bitter orange (Citrus aurantium) and its primary protoalkaloid p-synephrine. International Journal of Medical Sciences, 9, 527–538.

    Article  CAS  PubMed  Google Scholar 

  7. Dragull, K., Breksa, A. P., & Cain, B. (2008). Synephrine content of juice from Satsuma mandarins (Citrus unshiu Marcovitch). Journal of Agricultural and Food Chemistry, 56, 8874–8878.

    Article  CAS  PubMed  Google Scholar 

  8. Uckoo, R. M., Jayaprakasha, G. K., Nelson, D. S., & Patil, B. S. (2010). Rapid simultaneous determinations of amines and organic acids in citrus using high-performance liquid chromatography. Talanta, 83, 948–954.

    Article  PubMed  Google Scholar 

  9. Kaats, G. R., Miller, H., Preuss, H. G., & Stohs, S. J. (2013). A 60 day double-blind, placebo-controlled safety study involving Citrus aurantium (bitter orange) extract. Food and Chemical Toxicology, 55, 358–362.

    Article  CAS  PubMed  Google Scholar 

  10. Stohs, S. J., Preuss, H. G., Keith, S. C., Keith, P. L., Miller, H., & Kaats, G. R. (2011). Effects of p-synephrine alone and in combination with selected bioflavonoids on resting metabolism, blood pressure, heart rate and self-reported mood changes. International Journal of Medical Sciences, 8, 295–301.

    Article  CAS  PubMed  Google Scholar 

  11. Seifert, J. G., Nelson, A., Devonish, J., Burke, E. R., & Stohs, S. J. (2011). Effect of acute administration of an herbal preparation on blood pressure and heart rate in humans. International Journal of Medical Sciences, 8, 192–197.

    Article  PubMed  Google Scholar 

  12. Stohs, S. J., Preuss, H. G., & Shara, M. (2011). A review of the receptor-binding properties of p-synephrine as related to its pharmacological effects. Oxidative Medicine and Cellular Longevity,. doi:10.1155/2011/4829739pages.

    PubMed  Google Scholar 

  13. Marles R. (2011). Synephrine, Octopamine and Caffeine health risk assessment (HRA) Report. health Canada natural health products directorate, File No. 172091, pp.1-49. http://www.nutratechinc.com/advz/advz.php?p=2.

  14. Lynch B. (2013). Review of the safety data available on p-synephrine, caffeine and p-synephrine-caffeine containing combination products. Intertek-Cantox Report. February 19, pp. 1-20. http://nutratechinc.com/advz/UploadedFiles/2013/IntertekCantox.pdf.

Download references

Conflict of interest

The author has served as a consultant for Nutratech Inc., West Caldwell, NJ, a supplier of Citrus aurantium (bitter orange) extracts.

Author information

Authors and Affiliations

  1. Dean Emeritus, Creighton University Medical Center, Omaha, NE, 67178, USA

    Sidney J. Stohs

Authors
  1. Sidney J. Stohs
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Sidney J. Stohs.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Stohs, S.J. Questionable Conclusions in the Article “Cardiovascular Toxicity of Citrus aurantium in Exercised Rats”. Cardiovasc Toxicol 13, 180–181 (2013). https://doi.org/10.1007/s12012-013-9210-6

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12012-013-9210-6

Keywords

Search

Navigation