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Tissue-Specific Regulation of the Contents and Correlations of Mineral Elements in Hens by Zinc Oxide Nanoparticles

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Abstract

Due to their small size, zinc oxide (ZnO) nanoparticles (NPs) are readily absorbed and easily cross biological barriers, which make them promising candidates as diet additives. However, some studies have reported that ZnO NPs cause toxicity; therefore, their safety and potency as diet additives for farm animals should be established. This study was the first to fully evaluate the effects of ZnO NPs on the homeostasis of eight elements in seven organs/tissues. The regulation of element homeostasis was found to be organ specific with no influence on oxidation status, anti-oxidation capability, or organ damage. ZnO NPs may specifically regulate the homeostasis of mineral elements and affect the following correlations: (1) between the element content in each organ and the concentration of Zn used in ZnSO4 or ZnO NP treatments; (2) between ZnO NP and ZnSO4 treatments for the same element in each organ; and (3) between elements (in each organ in ZnSO4 or ZnO NP treatments) in layers’ organs/tissues. The use of ZnO NPs as diet additives for animals should be implemented cautiously because, among other uncertainties, they may affect mineral element content.

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Acknowledgments

This work was supported by the National Natural Science Foundation of China (31402256), Qingdao Technology Innovation Program for Application Foundation (14-2-4-22-jch), and QingDao Agricultural University Outstanding Research Foundation.

The TEM and EDS work in this study made use of the resources of the Beijing National Center for Electron Microscopy at Tsinghua University. We would like to thank Ms. Hui-Hua Zhou in Tsinghua University for helping with these analyses.

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Authors and Affiliations

  1. College of Chemistry and Pharmaceutical Sciences, Qingdao Agricultural University, Qingdao, 266109, People’s Republic of China

    Yong Zhao, Peng-Fei Zhang, Xin-Qi Liu, Wei-Dong Zhang, Ting-Ting Huang, Li Zhao & Zhi-Hui Hao

  2. Key Laboratory of Animal Reproduction and Germplasm Enhancement in Universities of Shandong, Qingdao, 266109, People’s Republic of China

    Yong Zhao, Yan-Ni Feng, Lan Li, Peng-Fei Zhang, Wei-Dong Zhang & Wei Shen

  3. State Key Laboratory of Animal Nutrition, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing, 100193, People’s Republic of China

    Hong-Fu Zhang

  4. Core Laboratories of Qingdao Agricultural University, Qingdao, 266109, People’s Republic of China

    Yu-Na Zhang

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  1. Yong Zhao
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  2. Yan-Ni Feng
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  3. Lan Li
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  10. Li Zhao
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  11. Wei Shen
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Correspondence to Zhi-Hui Hao.

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Zhao, Y., Feng, YN., Li, L. et al. Tissue-Specific Regulation of the Contents and Correlations of Mineral Elements in Hens by Zinc Oxide Nanoparticles. Biol Trace Elem Res 177, 353–366 (2017). https://doi.org/10.1007/s12011-016-0847-4

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  • DOI: https://doi.org/10.1007/s12011-016-0847-4

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