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Ameliorative Effects of Dietary Selenium Against Cadmium Toxicity Is Related to Changes in Trace Elements in Chicken Kidneys

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Abstract

The ameliorative effects of selenium (Se) against cadmium (Cd)-induced toxicity have been reported extensively. However, few studies have assessed the effects of multiple ions simultaneously on the variations of elements. In this study, the changes in Se, Cd, and 26 other element concentrations were investigated in chicken kidneys. One hundred and twenty-eight 31-week-old laying hens were fed a diet supplemented with either Se, Cd, or both Se and Cd for 90 days. The ion content was analyzed by inductively coupled plasma mass spectrometry (ICP-MS). We found that the Se, Cd, and combined Se and Cd treatments significantly affected the trace elements in the chicken kidneys. The Cd supplement caused ion profile disorders, including reduced concentrations of V, Cr, Mn, Mo, As, Ba, Hg, Ti, and Pb and increased Si, Cu, Li, Cd, and Sb. The Se supplement reduced the contents of Co, Mo, and Pb and increased the contents of Cr, Fe, and Se. Moreover, Se also increased the concentrations of Cr, Mn, Zn, and Se and decreased those of Li and Pb, which in contrast were induced by Cd. Complex interactions between elements were analyzed, and both positive and negative correlations among these elements are presented. The present study indicated that Se can help against the negative effects of Cd and may be related to the homeostasis of the trace elements in chicken kidneys.

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Acknowledgments

This work was supported by the China Postdoctoral Science Foundation (Grant No. 2016M591505), the Natural Science Foundation of the Heilongjiang Province of China (Grant No. C200932), and the Heilongjiang Postdoctoral Fund (Grant No. LBH-Z14223). All authors have read the manuscript and have agreed to submit it in its current form for consideration for publication in the journal.

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Authors and Affiliations

  1. College of Animal Science and Technology, Northeast Agricultural University, Harbin, 150030, People’s Republic of China

    Runxiang Zhang, Yanan Wang, Chao Wang, Peng Zhao & Jun Bao

  2. College of Life Science, Northeast Agricultural University, Harbin, 150030, People’s Republic of China

    Huo Liu & Jianhong Li

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  1. Runxiang Zhang
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  2. Yanan Wang
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  3. Chao Wang
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  4. Peng Zhao
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  5. Huo Liu
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  6. Jianhong Li
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  7. Jun Bao
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Correspondence to Jianhong Li or Jun Bao.

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All procedures used in the present study were approved by the Institutional Animal Care and Use Committee of Northeast Agricultural University.

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The authors declare that they have no conflicts of interest.

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Zhang, R., Wang, Y., Wang, C. et al. Ameliorative Effects of Dietary Selenium Against Cadmium Toxicity Is Related to Changes in Trace Elements in Chicken Kidneys. Biol Trace Elem Res 176, 391–400 (2017). https://doi.org/10.1007/s12011-016-0825-x

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