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Serum Macroelement and Microelement Concentrations in Patients with Polycystic Ovary Syndrome: a Cross-Sectional Study

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Abstract

Polycystic ovarian syndrome (PCOS) is one of the most common endocrine diseases. However, its pathogenesis is unclear. We aim to explore the potential relationships between serum macroelements/microelements and PCOS. A total of 1137 women were involved in the current study. PCOS was defined according to ESHRE/ASRM, and complete blood samples were collected. Serum macroelements (calcium and magnesium) and microelements (copper, zinc, and iron) were assayed through atomic absorption spectrophotometry. PCOS patients had significantly higher copper concentrations than patients without PCOS (P < 0.001). By contrast, PCOS patients had lower serum calcium levels than patients without PCOS (P < 0.001). No significant differences were observed in the levels of serum zinc, magnesium, and iron between PCOS and non-PCOS patients. PCOS patients with acne had higher magnesium levels than those without acne (P = 0.020), and PCOS patients with hirsutism had lower magnesium levels than those without hirsutism (P = 0.037). High serum copper and low calcium levels may be correlated with PCOS. Magnesium concentrations are correlated with acne and hirsutism in PCOS patients. These results provide clues to explore the mechanism of PCOS and guidance for element treatments in PCOS patients.

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References

  1. Duncan WC (2014) A guide to understanding polycystic ovary syndrome (PCOS). J Fam Plan Reprod Health Care/Fac Fam Plan Reprod Health Care Roy Coll Obstetricians Gynaecologists 40(3):217–225. doi:10.1136/jfprhc-2012-100505

    Article  Google Scholar 

  2. Nandi A, Chen Z, Patel R, Poretsky L (2014) Polycystic ovary syndrome. Endocrinol Metab Clin N Am 43(1):123–147. doi:10.1016/j.ecl.2013.10.003

    Article  Google Scholar 

  3. 2004) Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Hum Reprod 19(1):41–47

  4. Hung JH, Hu LY, Tsai SJ, Yang AC, Huang MW, Chen PM, Wang SL, Lu T, Shen CC (2014) Risk of psychiatric disorders following polycystic ovary syndrome: a nationwide population-based cohort study. PLoS One 9(5):e97041. doi:10.1371/journal.pone.0097041

    Article  PubMed  PubMed Central  Google Scholar 

  5. Balen A, Rajkowha M (2003) Polycystic ovary syndrome—a systemic disorder? Best Pract Res Clin Obstet Gynaecol 17(2):263–274

    Article  PubMed  Google Scholar 

  6. Chakraborty P, Ghosh S, Goswami SK, Kabir SN, Chakravarty B, Jana K (2013) Altered trace mineral milieu might play an aetiological role in the pathogenesis of polycystic ovary syndrome. Biol Trace Elem Res 152(1):9–15. doi:10.1007/s12011-012-9592-5

    Article  CAS  PubMed  Google Scholar 

  7. Yaman M, Kaya G, Yekeler H (2007) Distribution of trace metal concentrations in paired cancerous and non-cancerous human stomach tissues. World J Gastroenterol 13(4):612–618

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Benaglia L, Paffoni A, Mangiarini A, Restelli L, Bettinardi N, Somigliana E, Vercellini P, Fedele L (2015) Intrafollicular iron and ferritin in women with ovarian endometriomas. Acta Obstet Gynecol Scand 94(6):646–653. doi:10.1111/aogs.12647

    Article  CAS  PubMed  Google Scholar 

  9. Yin Y, Han W, Wang Y, Zhang Y, Wu S, Zhang H, Jiang L, Wang R, Zhang P, Yu Y, Li B (2015) Identification of risk factors affecting impaired fasting glucose and diabetes in adult patients from Northeast China. Int J Environ Res Public Health 12(10):12662–12678. doi:10.3390/ijerph121012662

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Insenser M, Montes-Nieto R, Murri M, Escobar-Morreale HF (2013) Proteomic and metabolomic approaches to the study of polycystic ovary syndrome. Mol Cell Endocrinol 370(1–2):65–77. doi:10.1016/j.mce.2013.02.009

    Article  CAS  PubMed  Google Scholar 

  11. Sharifi F, Mazloomi S, Hajihosseini R, Mazloomzadeh S (2012) Serum magnesium concentrations in polycystic ovary syndrome and its association with insulin resistance. Gynecol Endocrinol: Off J Int Soc Gynecol Endocrinol 28(1):7–11. doi:10.3109/09513590.2011.579663

    Article  CAS  Google Scholar 

  12. Celik C, Bastu E, Abali R, Alpsoy S, Guzel EC, Aydemir B, Yeh J (2013) The relationship between copper, homocysteine and early vascular disease in lean women with polycystic ovary syndrome. Gynecol Endocrinol: Off J Int Soc Gynecol Endocrinol 29(5):488–491. doi:10.3109/09513590.2013.774361

    Article  CAS  Google Scholar 

  13. Escobar-Morreale HF (2012) Iron metabolism and the polycystic ovary syndrome. Trends Endocrinol Metab: TEM 23(10):509–515. doi:10.1016/j.tem.2012.04.003

    Article  CAS  PubMed  Google Scholar 

  14. Guler I, Himmetoglu O, Turp A, Erdem A, Erdem M, Onan MA, Taskiran C, Taslipinar MY, Guner H (2014) Zinc and homocysteine levels in polycystic ovarian syndrome patients with insulin resistance. Biol Trace Elem Res 158(3):297–304. doi:10.1007/s12011-014-9941-7

    Article  CAS  PubMed  Google Scholar 

  15. Evangelopoulos AA, Vallianou NG, Panagiotakos DB, Georgiou A, Zacharias GA, Alevra AN, Zalokosta GJ, Vogiatzakis ED, Avgerinos PC (2008) An inverse relationship between cumulating components of the metabolic syndrome and serum magnesium levels. Nutr Res (New York, NY) 28(10):659–663. doi:10.1016/j.nutres.2008.07.001

    Article  CAS  Google Scholar 

  16. Tang JX, Li JR, Liu ZL, Zhao H, Tao XM, Cheng ZS (2013) Effects of Zn(2)(+) and Cu(2)(+) on loach ovaries and ova development. Dong wu xue yan jiu = Zoological research/ “Dong wu xue yan jiu” bian ji wei yuan hui bian ji 34(E4–5):E135–E139

    CAS  Google Scholar 

  17. Chen TS, Chen YT, Liu CH, Sun CC, Mao FC (2015) Effect of chromium supplementation on element distribution in a mouse model of polycystic ovary syndrome. Biol Trace Elem Res 168(2):472–480. doi:10.1007/s12011-015-0384-6

    Article  CAS  PubMed  Google Scholar 

  18. The Rotterdam ESHRE/ASRM‐Sponsored PCOS Consensus Workshop Group (2004) Revised 2003 consensus on diagnostic criteria and long‐term health risks related to polycystic ovary syndrome (PCOS). Hum Reprod 19(1):41–47

  19. Kurdoglu Z, Kurdoglu M, Demir H, Sahin HG (2012) Serum trace elements and heavy metals in polycystic ovary syndrome. Hum Exp Toxicol 31(5):452–456. doi:10.1177/0960327111424299

    Article  CAS  PubMed  Google Scholar 

  20. Klotz LO, Kroncke KD, Buchczyk DP, Sies H (2003) Role of copper, zinc, selenium and tellurium in the cellular defense against oxidative and nitrosative stress. J Nutr 133(5 Suppl 1):1448s–1451s

    CAS  PubMed  Google Scholar 

  21. Maritim AC, Sanders RA, Watkins JB 3rd (2003) Diabetes, oxidative stress, and antioxidants: a review. J Biochem Mol Toxicol 17(1):24–38. doi:10.1002/jbt.10058

    Article  CAS  PubMed  Google Scholar 

  22. Chasapis CT, Loutsidou AC, Spiliopoulou CA, Stefanidou ME (2012) Zinc and human health: an update. Arch Toxicol 86(4):521–534. doi:10.1007/s00204-011-0775-1

    Article  CAS  PubMed  Google Scholar 

  23. Malavolta M, Giacconi R, Piacenza F, Santarelli L, Cipriano C, Costarelli L, Tesei S, Pierpaoli S, Basso A, Galeazzi R, Lattanzio F, Mocchegiani E (2010) Plasma copper/zinc ratio: an inflammatory/nutritional biomarker as predictor of all-cause mortality in elderly population. Biogerontology 11(3):309–319. doi:10.1007/s10522-009-9251-1

    Article  CAS  PubMed  Google Scholar 

  24. Gaetke LM, Chow CK (2003) Copper toxicity, oxidative stress, and antioxidant nutrients. Toxicology 189(1–2):147–163

    Article  CAS  PubMed  Google Scholar 

  25. Kurdoglu Z, Ozkol H, Tuluce Y, Koyuncu I (2012) Oxidative status and its relation with insulin resistance in young non-obese women with polycystic ovary syndrome. J Endocrinol Investig 35(3):317–321. doi:10.3275/7682

    CAS  Google Scholar 

  26. Zheng G, Wang L, Guo Z, Sun L, Wang L, Wang C, Zuo Z, Qiu H (2015) Association of serum heavy metals and trace element concentrations with reproductive hormone levels and polycystic ovary syndrome in a Chinese population. Biol Trace Elem Res 167(1):1–10. doi:10.1007/s12011-015-0294-7

    Article  CAS  PubMed  Google Scholar 

  27. Lerchbaum E, Giuliani A, Gruber HJ, Pieber TR, Obermayer-Pietsch B (2012) Adult-type hypolactasia and calcium intake in polycystic ovary syndrome. Clin Endocrinol 77(6):834–843. doi:10.1111/j.1365-2265.2012.04334.x

    Article  CAS  Google Scholar 

  28. Mazloomi S, Sharifi F, Hajihosseini R, Kalantari S, Mazloomzadeh S (2012) Association between Hypoadiponectinemia and low serum concentrations of calcium and vitamin D in women with polycystic ovary syndrome. ISRN Endocrinol 2012:949427. doi:10.5402/2012/949427

    Article  PubMed  PubMed Central  Google Scholar 

  29. Firouzabadi R, Aflatoonian A, Modarresi S, Sekhavat L, MohammadTaheri S (2012) Therapeutic effects of calcium & vitamin D supplementation in women with PCOS. Complement Ther Clin Pract 18(2):85–88. doi:10.1016/j.ctcp.2012.01.005

    Article  PubMed  Google Scholar 

  30. Naziroglu M, Dikici DM, Dursun S (2012) Role of oxidative stress and Ca(2)(+) signaling on molecular pathways of neuropathic pain in diabetes: focus on TRP channels. Neurochem Res 37(10):2065–2075. doi:10.1007/s11064-012-0850-x

    Article  CAS  PubMed  Google Scholar 

  31. Muneyyirci-Delale O, Nacharaju VL, Dalloul M, Jalou S, Rahman M, Altura BM, Altura BT (2001) Divalent cations in women with PCOS: implications for cardiovascular disease. Gynecol Endocrinol: Off J Int Soc Gynecol Endocrinol 15(3):198–201

    Article  CAS  Google Scholar 

  32. Coskun A, Arikan T, Kilinc M, Arikan DC, Ekerbicer HC (2013) Plasma selenium levels in Turkish women with polycystic ovary syndrome. Eur J Obstet Gynecol Reprod Biol 168(2):183–186. doi:10.1016/j.ejogrb.2013.01.021

    Article  CAS  PubMed  Google Scholar 

  33. Kechrid Z, Hamdi M, Naziroglu M, Flores-Arce M (2012) Vitamin D supplementation modulates blood and tissue zinc, liver glutathione and blood biochemical parameters in diabetic rats on a zinc-deficient diet. Biol Trace Elem Res 148(3):371–377. doi:10.1007/s12011-012-9383-z

    Article  CAS  PubMed  Google Scholar 

  34. Rajpathak SN, Crandall JP, Wylie-Rosett J, Kabat GC, Rohan TE, Hu FB (2009) The role of iron in type 2 diabetes in humans. Biochim Biophys Acta 1790(7):671–681. doi:10.1016/j.bbagen.2008.04.005

    Article  CAS  PubMed  Google Scholar 

  35. Ko PC, Huang SY, Hsieh CH, Hsu MI, Hsu CS (2015) Serum ferritin levels and polycystic ovary syndrome in obese and nonobese women. Taiwan J Obstet Gynecol 54(4):403–407. doi:10.1016/j.tjog.2014.06.005

    Article  PubMed  Google Scholar 

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Acknowledgments

This research was supported by grants from the Science and Technology Development Program of Guangxi (No 1298003-6-4). We would like to thank Guangxi Population and Family Planning Research Center for sample support.

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Authors and Affiliations

  1. Experimental Centre of Medical Sciences, Guangxi Medical University, Nanning, Guangxi, 530000, China

    Muyan Li, Chunlei Lin, Qiaoying Huang, Danqing Lei & Yanling Hu

  2. Guangxi Reproductive Medical Research Center, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China

    Yuanyuan Tang

  3. Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, Guangxi, China

    Yanling Hu

  4. Guangxi Colleges and Universities Key Laboratory of Biological Molecular Medicine Research, Guangxi Medical University, Nanning, Guangxi, China

    Yanling Hu

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  1. Muyan Li
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Correspondence to Danqing Lei or Yanling Hu.

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This study was funded by the Science and Technology Development Program of Guangxi (grant number 1298003-6-4).

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The authors declare that they have no conflict of interest.

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Muyan Li and Yuanyuan Tang contributed equally to this work

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Li, M., Tang, Y., Lin, C. et al. Serum Macroelement and Microelement Concentrations in Patients with Polycystic Ovary Syndrome: a Cross-Sectional Study. Biol Trace Elem Res 176, 73–80 (2017). https://doi.org/10.1007/s12011-016-0782-4

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  • DOI: https://doi.org/10.1007/s12011-016-0782-4

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