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Dietary selenium increases the antioxidant levels and ATPase activity in the arteries and veins of poultry

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Abstract

Selenium (Se) deficiency is associated with the pathogenesis of vascular diseases. It has been shown that oxidative levels and ATPase activity were involved in Se deficiency diseases in humans and mammals; however, the mechanism by how Se influences the oxidative levels and ATPase activity in the poultry vasculature is unclear. We assessed the effects of dietary Se deficiency on the oxidative stress parameters (superoxide dismutase, catalase, and hydroxyl radical) and ATPase (Na+K+-ATPase, Ca++-ATPase, Mg++-ATPase, and Ca++Mg++-ATPase) activity in broiler poultry. A total of 40 broilers (1-day old) were randomly divided into a Se-deficient group (L group, fed a Se-deficient diet containing 0.08 mg/kg Se) and a control group (C group, fed a diet containing sodium selenite at 0.20 mg/kg Se). Then, arteries and veins were collected following euthanasia when typical symptoms of Se deficiency appeared. Antioxidant indexes and ATPase activity were evaluated using standard assays in arteries and veins. The results indicated that superoxide dismutase activity in the artery according to dietary Se deficiency was significantly lower (p < 0.05) compared with the C group. The catalase activity in the veins and hydroxyl radical inhibition in the arteries and veins by dietary Se deficiency were significantly higher (p < 0.05) compared with the C group. The Se-deficient group showed a significantly lower (p < 0.05) tendency in Na+K+-ATPase activity, Ca++-ATPase activity, and Ca++Mg++-ATPase activity. There were strong correlations between antioxidant indexes and Ca++-ATPase activity. Thus, these results indicate that antioxidant indexes and ATPases may have special roles in broiler artery and vein injuries under Se deficiency.

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Acknowledgements

This study was supported by the International (Regional) Cooperation and Exchange Projects of the National Natural Science Foundation of China (31320103920). The authors thank the members of the veterinary department medicine laboratory at the College of Veterinary Medicine, Northeast Agricultural University, for their help in collecting the vascular tissue samples.

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  1. College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, People’s Republic of China

    Changyu Cao, Xia Zhao, Ruifeng Fan, Jinxin Zhao, Yilin Luan, Ziwei Zhang & Shiwen Xu

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  1. Changyu Cao
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  2. Xia Zhao
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  3. Ruifeng Fan
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  4. Jinxin Zhao
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Correspondence to Ziwei Zhang or Shiwen Xu.

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All procedures used in this study were approved by the Institutional Animal Care and Use Committee of the Northeast Agricultural University.

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Cao, C., Zhao, X., Fan, R. et al. Dietary selenium increases the antioxidant levels and ATPase activity in the arteries and veins of poultry. Biol Trace Elem Res 172, 222–227 (2016). https://doi.org/10.1007/s12011-015-0584-0

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