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Effects of Local Administration of Boric Acid on Posterolateral Spinal Fusion with Autogenous Bone Grafting in a Rodent Model

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Abstract

Spinal fusion is among the most frequently applied spinal surgical procedures. The goal of the present study was to evaluate whether the local administration of boric acid (BA) improves spinal fusion in an experimental spinal fusion model in rats. Currently, there is no published data that evaluates the possible positive effects if the local administration of BA on posterolateral spinal fusion. Thirty-two rats were randomly divided into four independent groups: no material was added at the fusion area for group 1; an autogenous morselized corticocancellous bone graft was used for group 2; an autogenous morselized corticocancellous bone graft with boric acid (8.7 mg/kg) for group 3; and only boric acid was placed into the fusion area for group 4. The L4-L6 spinal segments were collected at week 6, and the assessments included radiography, manual palpation, and histomorphometry. A statistically significant difference was determined between the groups with regard to the mean histopathological scores (p = 0.002), and a paired comparison was made with the Mann-Whitney U test to detect the group/groups from which the difference originated. It was determined that only the graft + BA practice increased the histopathological score significantly with regard to the control group (p = 0.002). Whereas, there was no statistically significant difference between the groups in terms of the manual assessment of fusion and radiographic analysis (respectively p = 0.328 and p = 0.196). This preliminary study suggests that BA may clearly be useful as a therapeutic agent in spinal fusion. However, further research is required to show the most effective dosage of BA on spinal fusion, and should indicate whether BA effects spinal fusion in the human body.

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Acknowledgments

No benefits in any form have been or will be received from a commercial party related directly or indirectly to the subject of this manuscript.

Conflict of Interest

There are no conflicts of interest related to the manuscript. No funds were received in support of this study.

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Authors and Affiliations

  1. Faculty of Medicine, Department of Orthopaedics and Traumatology, Çanakkale Onsekiz Mart University, Çanakkale, Turkey

    Erkam Kömürcü, Burak Kaymaz, Umut Hatay Gölge & Ferdi Göksel

  2. Faculty of Medicine, Department of Pathology, Bolu Abant İzzet Baysal University, Bolu, Turkey

    Gülzade Özyalvaçlı

  3. Faculty of Medicine, Department of Public Health, Çanakkale Onsekiz Mart University, Çanakkale, Turkey

    Sibel Cevizci

  4. Faculty of Medicine, Department of Radiology, Çanakkale Onsekiz Mart University, Çanakkale, Turkey

    Gürhan Adam

  5. Faculty of Medicine, Department of Orthopaedics and Traumatology, Mustafa Kemal University, Hatay, Turkey

    Raif Ozden

  6. Hamidiye mah. Rauf Denktaş sok. Konakkale A1 Blok Daire 23, Kepez Çanakkale,, 17100, Turkey

    Erkam Kömürcü

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  1. Erkam Kömürcü
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Kömürcü, E., Özyalvaçlı, G., Kaymaz, B. et al. Effects of Local Administration of Boric Acid on Posterolateral Spinal Fusion with Autogenous Bone Grafting in a Rodent Model. Biol Trace Elem Res 167, 77–83 (2015). https://doi.org/10.1007/s12011-015-0274-y

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