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Dietary Intake of Magnesium May Modulate Depression

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Abstract

Depressive symptoms are frequent in students and may lead to countless problems. Several hypotheses associate magnesium with depression because of the presence of this mineral in several enzymes, hormones, and neurotransmitters, which may play a key role in the pathological pathways of depression. The aim of this study was to assess whether magnesium intake could modulate depressive symptoms. A cross-sectional study was conducted on a convenience sample of 402 Iranian postgraduate students studying in Malaysia to assess the relationship between magnesium intake and depressive symptoms. The mean age of the participants was 32.54 ± 6.22 years. The results of the study demonstrated an inverse relationship between magnesium intake and depressive symptoms, which persisted even after adjustments for sex, age, body mass index, monthly expenses, close friends, living on campus, smoking (current and former), education, physical activity, and marital status.

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References

  1. Patel V, Kleinman A (2003) Poverty and common mental disorders in developing countries. B World Health Organ 81:609–615

    Google Scholar 

  2. Lakhan SE, Vieira KF (2010) Nutritional and herbal supplements for anxiety and anxiety-related disorders: systematic review. Nutr J 9:42

    Article  PubMed  Google Scholar 

  3. Abbott RD, Ando F, Masaki KH, Tung KH, Rodriguez BL, Petrovitch H, Yano K, Curb JD (2003) Dietary magnesium intake and the future risk of coronary heart disease (the Honolulu Heart Program). Am J Cardiol 92:665–669

    Article  PubMed  CAS  Google Scholar 

  4. Agarwal M, Hamilton JB, Moore CE, Crandell JL (2010) Predictors of depression among older African American cancer patients. Cancer Nurs 33:156

    PubMed  Google Scholar 

  5. Khawaja NG, Bryden KJ (2006) The development and psychometric investigation of the university student depression inventory. J Affect Disord 96:21–29

    Article  PubMed  Google Scholar 

  6. Yary T, Aazami S (2012) Dietary intake of zinc was inversely associated with depression. Biol Trace Elem Res 145:286–290

    Article  PubMed  CAS  Google Scholar 

  7. Yary T, Aazami S (2011) The association between polyunsaturated fatty acids and depression among Iranian postgraduate students in Malaysia. Lipids Health Dis 10:151

    Article  PubMed  CAS  Google Scholar 

  8. Nrugham L, Larsson B, Sund AM (2008) Predictors of suicidal acts across adolescence: influences of familial, peer and individual factors. J Affect Disord 109:35–45

    Article  PubMed  Google Scholar 

  9. Demir T, Karacetin G, Demir DE, Uysal O (2011) Epidemiology of depression in an urban population of Turkish children and adolescents. J Affect Disord 134:168–176

    Article  PubMed  Google Scholar 

  10. Stewart JA, Deliyannides DA, Hellerstein DJ, McGrath PJ, Stewart JW (2012) Can people with nonsevere major depression benefit from antidepressant medication? J Clin Psychiatry 73:518–525

    Article  PubMed  CAS  Google Scholar 

  11. Eby GA III, Eby KL (2010) Magnesium for treatment-resistant depression: a review and hypothesis. Med Hypotheses 74:649–660

    Article  PubMed  CAS  Google Scholar 

  12. Eby GA, Eby KL (2006) Rapid recovery from major depression using magnesium treatment. Med Hypotheses 67:362–370

    Article  PubMed  CAS  Google Scholar 

  13. Camardese G, De Risio L, Pizi G, Mattioli B, Buccelletti F, Serrani R, Leone B, Sgambato A, Bria P, Janiri L (2012) Plasma magnesium levels and treatment outcome in depressed patients. Nutr Neurosci 15:78–84

    PubMed  CAS  Google Scholar 

  14. Jodral-Segado AM, Navarro-Alarcon M (2003) Magnesium and calcium contents in foods from SE Spain: influencing factors and estimation of daily dietary intakes. Sci Total Environ 312:47–58

    Article  PubMed  CAS  Google Scholar 

  15. Nielsen FH (2010) Magnesium, inflammation, and obesity in chronic disease. Nutr Rev 68:333–340

    Article  PubMed  Google Scholar 

  16. Schimatschek HF, Rempis R (2001) Prevalence of hypomagnesemia in an unselected German population of 16,000 individuals. Magnes Res 14:283

    PubMed  CAS  Google Scholar 

  17. Singewald N, Sinner C, Hetzenauer A, Sartori SB, Murck H (2004) Magnesium-deficient diet alters depression- and anxiety-related behavior in mice—influence of desipramine and Hypericum perforatum extract. Neuropharmacology 47:1189–1197

    Article  PubMed  CAS  Google Scholar 

  18. Radloff LS (1977) The CES-D scale: a self-report depression scale for research in the general population. Appl Psychol Meas 1:385

    Article  Google Scholar 

  19. Willett WC, Sampson L, Stampfer MJ, Rosner B, Bain C, Witschi J, Hennekens CH, Speizer FE (1985) Reproducibility and validity of a semiquantitative food frequency questionnaire. Am J Epidemiol 122:51–65

    PubMed  CAS  Google Scholar 

  20. Kimiagar SM, Ghaffarpour M, Houshiar-Rad A, Hormozdyari H, Zellipour L (1998) Food consumption pattern in the Islamic Republic of Iran and its relation to coronary heart disease. East Mediterr Health J 4:539–547

    Google Scholar 

  21. Romieu I, Parra S, Hernández JF, Madrigal H, Willett W, Hernández M (2005) Questionnaire assessment of antioxidants and retinol intakes in Mexican women. Arch Med Res 30:224–239

    Article  Google Scholar 

  22. Poleszak E, Szewczyk B, Kdzierska E, Wlaz P, Pilc A, Nowak G (2004) Antidepressant- and anxiolytic-like activity of magnesium in mice. Pharmacol Biochem Behav 78:7–12

    Article  PubMed  CAS  Google Scholar 

  23. Jacka FN, Overland S, Stewart R, Tell GS, Bjelland I, Mykletun A (2009) Association between magnesium intake and depression and anxiety in community-dwelling adults: the Hordaland Health Study. Aust N Z J Psychiatr 43:45–52

    Article  Google Scholar 

  24. Murck H (2002) Magnesium and affective disorders. Nutr Neurosci 5:375–389

    Article  PubMed  CAS  Google Scholar 

  25. Davison KM (2011) The determinants of food intake in individuals with mood disorders

  26. DeVinney R, Wang HH (1995) Mg2+ enhances high affinity [3H]8-hydroxy-2-(di-n-propylamino) tetralin binding and guanine nucleotide modulation of serotonin-1a receptors. J Recept Signal Transduct Res 15:757–771

    Article  PubMed  CAS  Google Scholar 

  27. Morris ME (1992) Brain and CSF magnesium concentrations during magnesium deficit in animals and humans: neurological symptoms. Magnes Res 5:303

    PubMed  CAS  Google Scholar 

  28. Sartori SB, Whittle N, Hetzenauer A, Singewald N (2012) Magnesium deficiency induces anxiety and HPA axis dysregulation: Modulation by therapeutic drug treatment. Neuropharmacology 62:304–312

    Article  PubMed  CAS  Google Scholar 

  29. Murck H, Steiger A (1998) Mg2+ reduces ACTH secretion and enhances spindle power without changing delta power during sleep in men—possible therapeutic implications. Psychopharmacology 137:247–252

    Article  PubMed  CAS  Google Scholar 

  30. Musselman DL, Evans DL, Nemeroff CB (1998) The relationship of depression to cardiovascular disease: epidemiology, biology, and treatment. Arch Gen Psychiatr 55:580–592

    Article  PubMed  CAS  Google Scholar 

  31. Yary T, Soleimannejad K, Rahim A, Kandiah M, Aazami S, Poor J, Wee T, Aazami G (2010) Contribution of diet and major depression to incidence of acute myocardial infarction(AMI). Lipids Health Dis 9:133

    Article  PubMed  Google Scholar 

  32. McAfoose J, Baune BT (2009) Evidence for a cytokine model of cognitive function. Neurosci Biobehav Rev 33:355–366

    Article  PubMed  CAS  Google Scholar 

  33. Malpuech-Brugere C, Nowacki W, Rock E, Gueux E, Mazur A, Rayssiguier Y (1999) Enhanced tumor necrosis factor-alpha production following endotoxin challenge in rats is an early event during magnesium deficiency. BBA-Mol Basis Dis 1453:35–40

    Article  CAS  Google Scholar 

  34. Yap SH, Moshage HJ, Hazenberg BPC, Roelofs HMJ, Bijzet J, Limburg PC, Aarden LA, Van Rijswijk MH (1991) Tumor necrosis factor (TNF) inhibits interleukin (IL)-1 and/or IL-6 stimulated synthesis of C-reactive protein (CRP) and serum amyloid A (SAA) in primary cultures of human hepatocytes. BBA-Mol Cell Biol Lipids 1091:405–408

    Article  CAS  Google Scholar 

  35. Uchakin PN, Tobin B, Cubbage M, Marshall G Jr, Sams C (2001) Immune responsiveness following academic stress in first-year medical students. J Interf Cytokine Res 21:687–694

    Article  CAS  Google Scholar 

  36. Song Y, Ridker PM, Manson JAE, Cook NR, Buring JE, Liu S (2005) Magnesium intake, C-reactive protein, and the prevalence of metabolic syndrome in middle-aged and older US women. Diabetes Care 28:1438

    Article  PubMed  CAS  Google Scholar 

  37. King DE, Mainous AG III, Geesey ME, Egan BM, Rehman S (2006) Magnesium supplement intake and C-reactive protein levels in adults. Nutr Res 26:193–196

    Article  CAS  Google Scholar 

  38. Beutler B, Cerami A (1986) Cachectin/tumor necrosis factor: an endogenous mediator of shock and inflammation. Immunol Res 5:281–293

    Article  PubMed  CAS  Google Scholar 

  39. Kramer JH, Mak IT, Phillips TM, Weglicki WB (2003) Dietary magnesium intake influences circulating pro-inflammatory neuropeptide levels and loss of myocardial tolerance to postischemic stress. Exp Biol Med 228:665

    CAS  Google Scholar 

  40. Kessler RC, McGonagle KA, Swartz M, Blazer DG, Nelson CB (1993) Sex and depression in the National Comorbidity Survey. I: lifetime prevalence, chronicity and recurrence. J Affect Disord 29:85–96

    Article  PubMed  CAS  Google Scholar 

  41. Noble RE (2005) Depression in women. Metabolism 54:49–52

    Article  PubMed  CAS  Google Scholar 

  42. Eriksson E, Andersch B, Ho HP, Landen M, Sundblad C (2002) Diagnosis and treatment of premenstrual dysphoria. J Clin Psychiatry 63:16–23

    PubMed  Google Scholar 

  43. Freeman EW, Sondheimer SJ, Rickels K (1997) Gonadotropin-releasing hormone agonist in the treatment of premenstrual symptoms with and without ongoing dysphoria: a controlled study. Psychopharmacol Bull 33:303–309

    PubMed  CAS  Google Scholar 

  44. Bhatia SC, Bhatia SK (2002) Diagnosis and treatment of premenstrual dysphoric disorder. Am Fam Physician 66:1239–1249

    PubMed  Google Scholar 

  45. Garde K (2007) Depression, gender differences. Ugeskr Laeger 169:2422–2445

    PubMed  Google Scholar 

  46. Piccinelli M, Wilkinson G (2000) Gender differences in depression. Critical review. Br J Psychiatry 177:486–492

    Article  PubMed  CAS  Google Scholar 

  47. Iezhitsa IN, Spasov AA, Kharitonova MV, Kravchenko MS (2011) Effect of magnesium chloride on psychomotor activity, emotional status, and acute behavioural responses to clonidine, d-amphetamine, arecoline, nicotine, apomorphine, and l-5-hydroxytryptophan. Nutr Neurosci 14:10–24

    Article  PubMed  CAS  Google Scholar 

  48. Otten JJ, Hellwig JP, Meyers LD (eds) (2006) Dietary reference intakes. National Academy Press, Washington, DC

    Google Scholar 

  49. No Author (1997) Dietary reference intakes for calcium, phosphorous, magnesium, vitamin D, and fluoride. http://www.iom.edu/~/media/Files/Activity%20Files/Nutrition/DRIs/DRI_Elements.pdf.

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Acknowledgments

We express our sincere appreciation to all the participants of this study. We also thank Dr. Javad Aazami, Dr. Siavash Yari and Dr. Yadollah Abolfathi Momtaz for encouraging and supporting this study.

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Authors and Affiliations

  1. Department of Cardiology, Faculty of Medicine and Health Sciences, Ilam University of Medical Sciences, 7134-69391, Banganjab, Ilam, Iran

    Teymoor Yary & Kourosh Soleimannejad

  2. Department of Community Health, Faculty of Medicine, University Kebangsaan Malaysia, 56000, Cheras, Kuala Lumpur, Malaysia

    Sanaz Aazami

Authors
  1. Teymoor Yary
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  2. Sanaz Aazami
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  3. Kourosh Soleimannejad
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Correspondence to Teymoor Yary.

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Yary, T., Aazami, S. & Soleimannejad, K. Dietary Intake of Magnesium May Modulate Depression. Biol Trace Elem Res 151, 324–329 (2013). https://doi.org/10.1007/s12011-012-9568-5

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  • DOI: https://doi.org/10.1007/s12011-012-9568-5

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