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Some Ethical Concerns About Human Induced Pluripotent Stem Cells

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Abstract

Human induced pluripotent stem cells can be obtained from somatic cells, and their derivation does not require destruction of embryos, thus avoiding ethical problems arising from the destruction of human embryos. This type of stem cell may provide an important tool for stem cell therapy, but it also results in some ethical concerns. It is likely that abnormal reprogramming occurs in the induction of human induced pluripotent stem cells, and that the stem cells generate tumors in the process of stem cell therapy. Human induced pluripotent stem cells should not be used to clone human beings, to produce human germ cells, nor to make human embryos. Informed consent should be obtained from patients in stem cell therapy.

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References

  • Boland, M. J., Hazen, J. L., Nazor, K. L., Rodriguez, A. R., Gifford, W., Martin, G., et al. (2009). Adult mice generated from induced pluripotent stem cells. Nature, 461(7260), 91–94.

    Article  Google Scholar 

  • Chen, L., Mizutani, A., Kasai, T., Yan, T., Jin, G., Vaidyanath, A., et al. (2014). Mouse induced pluripotent stem cell microenvironment generates epithelial–mesenchymal transition in mouse Lewis lung cancer cells. American Journal of Cancer Research, 4(1), 80–88.

    Google Scholar 

  • Churko, J. M., Burridge, P. W., & Wu, J. C. (2013). Generation of human iPSCs from human peripheral blood mononuclear cells using non-integrative Sendai virus in chemically defined conditions. Methods in Molecular Biology, 1036, 81–88.

    Article  Google Scholar 

  • Hayashi, K., Ogushi, S., Kurimoto, K., Shimamoto, S., Ohta, H., & Saitou, M. (2012). Offspring from oocytes derived from in vitro primordial germ cell-like cells in mice. Science, 338(6109), 971–975.

    Article  Google Scholar 

  • Hayashi, K., Ohta, H., Kurimoto, K., Aramaki, S., & Saitou, M. (2011). Reconstitution of the mouse germ cell specification pathway in culture by pluripotent stem cells. Cell, 146(4), 519–532.

    Article  Google Scholar 

  • Hayashi, K., & Saitou, M. (2013). Generation of eggs from mouse embryonic stem cells and induced pluripotent stem cells. Nature Protocols, 8(8), 1513–1524.

    Article  Google Scholar 

  • Kang, L., Wang, J., Zhang, Y., Kou, Z., & Gao, S. (2009). iPS cells can support full-term development of tetraploid blastocyst-complemented embryos. Cell Stem Cell, 5(2), 135–138.

    Article  Google Scholar 

  • Laurent, L. C., Ulitsky, I., Slavin, I., Tran, H., Schork, A., Morey, R., et al. (2011). Dynamic changes in the copy number of pluripotency and cell proliferation genes in human ESCs and iPSCs during reprogramming and time in culture. Cell Stem Cell, 8(1), 106–118.

    Article  Google Scholar 

  • Lister, R., Pelizzola, M., Kida, Y. S., Hawkins, R. D., Nery, J. R., Hon, G., et al. (2011). Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells. Nature, 471(7336), 68–73.

    Article  Google Scholar 

  • Maherali, N., Ahfeldt, T., Rigamonti, A., Utikal, J., Cowan, C., & Hochedlinger, K. (2008). A high-efficiency system for the generation and study of human induced pluripotent stem cells. Cell Stem Cell, 3(3), 340–345.

    Article  Google Scholar 

  • Mayshar, Y., Ben-David, U., Lavon, N., Biancotti, J. C., Yakir, B., Clark, A. T., et al. (2010). Identification and classification of chromosomal aberrations in human induced pluripotent stem cells. Cell Stem Cell, 7(4), 521–531.

    Article  Google Scholar 

  • Okita, K., Ichisaka, T., & Yamanaka, S. (2007). Generation of germline-competent induced pluripotent stem cells. Nature, 448(7151), 313–317.

    Article  Google Scholar 

  • Soldner, F., Hockemeyer, D., Beard, C., Gao, Q., Bell, G. W., Cook, E. G., et al. (2009). Parkinson’s disease patient-derived induced pluripotent stem cells free of viral reprogramming factors. Cell, 136(5), 964–977.

    Article  Google Scholar 

  • Soldner, F., Laganière, J., Cheng, A. W., Hockemeyer, D., Gao, Q., Alagappan, R., et al. (2011). Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations. Cell, 146(2), 318–331.

    Article  Google Scholar 

  • Takahashi, K., & Yamanaka, S. (2006). Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell, 126(4), 663–676.

    Article  Google Scholar 

  • Zhao, X. Y., Li, W., Lv, Z., Liu, L., Tong, M., Hai, T., et al. (2009). iPS cells produce viable mice through tetraploid complementation. Nature, 461(7260), 86–90.

    Article  Google Scholar 

  • Zhao, X. Y., Lv, Z., Li, W., Zeng, F., & Zhou, Q. (2010). Production of mice using iPS cells and tetraploid complementation. Nature Protocols, 5(5), 963–971.

    Article  Google Scholar 

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Authors and Affiliations

  1. College of Life Science, Linyi University, Linyi City, Shandong Province, China

    Yue Liang Zheng

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  1. Yue Liang Zheng
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Correspondence to Yue Liang Zheng.

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Zheng, Y.L. Some Ethical Concerns About Human Induced Pluripotent Stem Cells. Sci Eng Ethics 22, 1277–1284 (2016). https://doi.org/10.1007/s11948-015-9693-6

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  • DOI: https://doi.org/10.1007/s11948-015-9693-6

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