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Hippo/Yap Signaling in Cardiac Development and Regeneration

  • Regenerative Medicine and Stem-cell Therapy (S M Wu and P Hsieh, Section Editors)
  • Published:
Current Treatment Options in Cardiovascular Medicine Aims and scope Submit manuscript

Opinion statement

The heart has historically been considered to be a non-regenerative organ. Recent insights have suggested that cardiomyocytes have a small but measurable ability to regenerate. Moreover, recent work has also shown that manipulating the expression of specific genetic pathways can improve the ability of the heart to repair itself. These new insights set the stage for the development of new treatments for heart failure.

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References and Recommended Reading

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Acknowledgments

J.F.M was supported by the Transatlantic Network of Excellence Award LeDucq Foundation Transatlantic Networks of Excellence in Cardiovascular Research 14CVD01: “Defining the genomic topology of atrial fibrillation,” NIH Grants DE 023177 and HL 118761, and the Vivian L. Smith Foundation (J.F.M.)

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Authors and Affiliations

  1. Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX, 77030, USA

    Yang Xiao MB, MS, John Leach BS, Jun Wang PhD & James F. Martin MD, PhD

  2. Institute of Biosciences and Technology, Texas A&M Health Science Center, Houston, TX, 77030, USA

    Yang Xiao MB, MS & James F. Martin MD, PhD

  3. Cardiomyocyte Renewal Laboratory, Texas Heart Institute, Houston, TX, 77030, USA

    James F. Martin MD, PhD

  4. Program in Developmental Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX, 77030, USA

    James F. Martin MD, PhD

  5. Cardiovascular Research Institute, Baylor College of Medicine, Houston, TX, 77030, USA

    James F. Martin MD, PhD

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  1. Yang Xiao MB, MS
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  2. John Leach BS
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  4. James F. Martin MD, PhD
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Correspondence to James F. Martin MD, PhD.

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This article does not contain any studies with human or animal subjects performed by any of the authors.

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This article is part of the Topical Collection on Regenerative Medicine and Stem-cell Therapy

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Xiao, Y., Leach, J., Wang, J. et al. Hippo/Yap Signaling in Cardiac Development and Regeneration. Curr Treat Options Cardio Med 18, 38 (2016). https://doi.org/10.1007/s11936-016-0461-y

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  • DOI: https://doi.org/10.1007/s11936-016-0461-y

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