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The biologic basis for libido

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Abstract

Libido refers to a fluctuating state of sexual motivation in all organisms. Sexual motivation is altered by internal factors, such as circulating steroid hormone levels and feedback from sexual stimulation; external factors, such as the presence of sexually relevant incentives; and by the cognitive processing of these factors that provides variations in sexual arousability and expectation of sexual reward. Libido thus reflects constant fluctuations in sexual arousal, desire, reward, and inhibition. Recent advances in neurochemical detection, pharmacologic analyses, and brain imaging, have helped identify neuroanatomic and neurochemical systems that regulate these four aspects of sexual function. Another important factor is the activation of central monoamine and neuropeptide systems that link incentive motivation, reward, and inhibition together with autonomic pathways that detect and relay sexual arousal. The activation of these systems by steroid hormones, and modulation by expectancy of sexual reward, are critical features of the neural “state” in which reactivity to sexual incentives is altered.

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References and Recommended Reading

  1. Crenshaw TL, Goldberg JP: Sexual Pharmacology. New York: Norton; 1996.

    Google Scholar 

  2. Miller RA: The Magical and Ritual Use of Aphrodisiacs. Rochester, VT: Destiny Books; 1993.

    Google Scholar 

  3. Rowland DL, Cooper SE, Slob AK: Genital and psychoaffective response to erotic stimulation in sexually functional and dysfunctional men. J Abnorm Psychol 1996, 105:194–203.

    Article  CAS  PubMed  Google Scholar 

  4. Meston CM, Gorzalka BB: The effects of immediate, delayed, and residual sympathetic activation on sexual arousal in women. Behav Res Ther 1996, 34:143–148.

    Article  CAS  PubMed  Google Scholar 

  5. Meston CM, Heiman JR: Ephedrine-activated physiological sexual arousal in women. Arch Gen Psychiatry 1998, 55:652–656.

    Article  CAS  PubMed  Google Scholar 

  6. Meisel RL, Sachs BD: The physiology of male sexual behavior. In The Physiology of Reproduction, Second Edition. Edited by Knobil E, Neill JD. New York: Raven Press; 1994:3–105.

    Google Scholar 

  7. McKenna K: Central nervous system pathways involved in the control of penile erection. Annu Rev Sex Behav 1999, 10:157–183.

    CAS  Google Scholar 

  8. Hull EM, Eaton RC, Markowski VP, et al.: Opposite influence of medial preoptic D1 and D2 receptors on genital reflexes: implications for copulation. Life Sci 1992, 51:1705–1713.

    Article  CAS  PubMed  Google Scholar 

  9. Diamond LE, Earle DC, Rosen RC, et al.: Double-blind, placebocontrolled evaluation of the safety, pharmacokinetic properties, and pharmacodynamic effects of intranasal PT-141, a melanocortin receptor agonist, in healthy males and patients with mildto-moderate erectile dysfunction. Int J Impot Res 2004, 16:51–59.

    Article  CAS  PubMed  Google Scholar 

  10. Sachs BD, Akasofu K, Citron JH, et al.: Noncontact stimulation from estrous females evokes penile erection in rats. Physiol Behav 1994, 55:1073–1079.

    Article  CAS  PubMed  Google Scholar 

  11. Sachs BD: Contextual approaches to the physiology and classification of erectile function, erectile dysfunction, and sexual arousal. Neurosci Biobehav Rev 2000, 24:541–560.

    Article  CAS  PubMed  Google Scholar 

  12. Pehek EA, Thompson JT, Eaton RC, et al.: Apomorphine and haloperidol, but not domperidone, affect penile reflexes in rats. Pharmacol Biochem Behav 1988, 31:201–208.

    Article  CAS  PubMed  Google Scholar 

  13. Stoleru S, Gregoire MC, Gerard D, et al.: Neuroanatomical correlates of visually evoked sexual arousal in human males. Arch Sex Behav 1999, 28:1–21.

    Article  CAS  PubMed  Google Scholar 

  14. Redoute J, Stoleru S, Gregoire MC, et al.: Brain processing of visual sexual stimuli in human males. Hum Brain Mapp 2000, 11:162–177.

    Article  CAS  PubMed  Google Scholar 

  15. Bocher M, Chisin R, Parag Y, et al.: Cerebral activation associated with sexual arousal in response to a pornographic clip: a 15O-H2O PET study in heterosexual men. Neuroimage 2001, 14:105–117.

    Article  CAS  PubMed  Google Scholar 

  16. Karama S, Lecours AR, Leroux JM, et al.: Areas of brain activation in males and females during viewing of erotic film clips. Hum Brain Mapp 2002, 16:1–13.

    Article  PubMed  Google Scholar 

  17. Mouras H, Stoleru S, Bittoun J, et al.: Brain processing of visual sexual stimuli in healthy men: a functional magnetic resonance imaging study. Neuroimage 2003, 20:855–869.

    Article  PubMed  Google Scholar 

  18. Hamann S, Herman RA, Nolan CL, Wallen K: Men and women differ in amygdala response to visual sexual stimuli. Nat Neurosci 2004, 7:411–416. This study used fMRI to examine whether patterns of brain activation differ between men and women viewing the same visual sexual stimuli. Although men and women showed similar activation of a majority of brain regions, men had greater activation of the hypothalamus and amygdala relative to women overall and equal activation as women who reported increased sexual arousal after the presentation. Because men are reported to have a greater sensitivity to visual sexual stimuli compared to women, the activation of these structures may mediate the sex difference.

    Article  CAS  PubMed  Google Scholar 

  19. Stoleru S, Redoute J, Costes N, et al.: Brain processing of visual sexual stimuli in men with hypoactive sexual desire disorder. Psychiatry Res 2003, 124:67–86. This study used PET to examine differences in brain activation patterns between sexually healthy men and those with a diagnosis of HSDD while viewing visual sexual stimuli of graded stimulus intensity. A statistical mapping procedure was used to determine regions that were activated and deactivated between groups. Activation was found in frontal, somatosensory, and parietal cortices and in the cingulate gyrus in control subjects compared to men with HSDD. However, prolonged activation of medial orbitofrontal cortex occurred in men with HSDD relative to controls. Because the orbitofrontal cortex is involved in the general inhibition of motivation, these results have important implications for the neural basis of sexual arousal and inhibition.

    Article  PubMed  Google Scholar 

  20. Pfaus JG, Heeb MM: Implications of immediate-early gene induction in the brain following sexual stimulation of female and male rodents. Brain Res Bull 1997, 44:397–407.

    Article  CAS  PubMed  Google Scholar 

  21. Traish AM, Kim NN, Munarriz R, et al.: Biochemical and physiological mechanisms of female genital sexual arousal. Arch Sex Behav 2002, 31:393–400.

    Article  PubMed  Google Scholar 

  22. Scepkowski LA, Georgescu M, Pfaus JG: Neuroendocrine factors in sexual desire and motivation. In Female Sexual Dysfunction. Edited by Goldstein I, Meston C, Davis K, Traish A. London: Parthenon, In press.

  23. Basson R, Brotto LA: Sexual psychophysiology and effects of sildenafil citrate in oestrogenised women with acquired genital arousal disorder and impaired orgasm: a randomised controlled trial. Br J Obst Gyn 2003, 110:1014–1024.

    CAS  Google Scholar 

  24. American Psychiatric Association: Diagnostic and Statistical Manual of Psychiatric Disorders IV-TR (Text Revision). Washington, DC: APA Press; 2000.

    Book  Google Scholar 

  25. Basson R: Female sexual response: the role of drugs in the management of sexual dysfunction. Obst Gyn 2001, 98:350–353.

    Article  CAS  Google Scholar 

  26. Toledano RR, Pfaus JG: The sexual arousal and desire inventory: a multidimensional scale to assess the subjective experience of sexual arousal and desire. Arch Sex Behav 2005, In press.

  27. Pfaus JG, Kippin TE, Coria-Avila G: What can animal models tell us about human sexual function? Annu Rev Sex Res 2003, 14:1–63.

    PubMed  Google Scholar 

  28. Blackburn JR, Pfaus JG, Phillips AG: Dopamine functions in appetitive and defensive behaviours. Prog Neurobiol 1992, 39:247–279.

    Article  CAS  PubMed  Google Scholar 

  29. Pfaus JG, Phillips AG: Role of dopamine in anticipatory and consummatory aspects of sexual behavior in the male rat. Behav Neurosci 1991, 105:727–743.

    Article  CAS  PubMed  Google Scholar 

  30. Everitt BJ: Sexual motivation: a neural and behavioral analysis of the mechanisms underlying appetitive and copulatory responses of male rats. Neurosci Biobehav Rev 1990, 14:217–232.

    Article  CAS  PubMed  Google Scholar 

  31. Kippin TE, Cain SW, Pfaus JG: Estrous odors and sexually conditioned neutral odors activate separate neural pathways in the male rat. Neurosci 2003, 117:971–979.

    Article  CAS  Google Scholar 

  32. Pfaus JG, Shadiack A, Van Soest T, et al.: Selective facilitation of sexual solicitation in the female rat by a melanocortin agonist. Proc Natl Acad Sci USA 2004, 101:10201–10204. In this study, we reported that systemic administration of PT-141, a selective melanocortin receptor agonist, to female rats produced a selective facilitation of solicitation. However, the drug did not alter lordosis, locomotion, or CPP, suggesting that the drug produces a specific effect on measures of sexual desire rather than copulation or sexual reward.

    Article  CAS  PubMed  Google Scholar 

  33. Stanislaw H, Rice FJ: Correlation between sexual desire and menstrual cycle characteristics. Arch Sex Behav 1988, 17:499–508.

    Article  CAS  PubMed  Google Scholar 

  34. Agmo A, Berenfeld R: Reinforcing properties of ejaculation in the male rat: the role of opioids and dopamine. Behav Neurosci 1990, 104:177–182.

    Article  CAS  PubMed  Google Scholar 

  35. Paredes RG, Martinez I: Naloxone blocks place preference conditioning after paced mating in female rats. Behav Neurosci 2001, 115:117–127.

    Article  Google Scholar 

  36. Agmo A: Sexual motivation—an inquiry into events determining the occurrence of sexual behavior. Behav Brain Res 1999, 105:129–150.

    Article  CAS  PubMed  Google Scholar 

  37. Pfaus JG, Gorzalka BB: Opioids and sexual behavior. Neurosci Biobehav Rev 1987, 11:1–34.

    Article  CAS  PubMed  Google Scholar 

  38. Lorrain DS, Matuszewich L, Friedman RD, Hull EM: Extracellular serotonin in the lateral hypothalamic area is increased during the postejaculatory interval and impairs copulation in male rats. J Neurosci 1997, 17:9361–9366.

    CAS  PubMed  Google Scholar 

  39. Kippin TE, Sotiropoulos V, Badih J, Pfaus JG: Opposing roles of the nucleus accumbens and anterior lateral hypothalamic area in the control of sexual behaviour in the male rat. Eur J Neurosci 2004, 19:698–704.

    Article  PubMed  Google Scholar 

  40. Carter CS, Witt DM, Thompson EG, Carlstead K: Effects of hormonal, sexual, and social history on mating and pair bonding in prairie voles. Physiol Behav 1988, 44:691–697.

    Article  CAS  PubMed  Google Scholar 

  41. Insel TR: A neurobiological basis of social attachment. Am J Psychiatry 1997, 154:726–735.

    CAS  PubMed  Google Scholar 

  42. Lim MM, Wang Z, Olazabal DE, et al.: Enhanced partner preference in a promiscuous species by manipulating the expression of a single gene. Nature 2004, 429:754–757. Libido is almost always directed toward sexual incentives in the external world. Even in fantasy, the persons or situations fantasized about are typically externalized. This study shows just how malleable the system is. One important difference between the brains of monogamous versus polygamous voles concerns a population of V1a receptors in the ventral pallidum, a region that receives dopamine-modulated input from the nucleus accumbens and controls goal-directed movements. These receptors are greater in density in monogamous voles than in polygamous voles. To examine whether these receptors are important in the display of selective partner preference, the authors constructed an adeno-associated viral vector that contained the V1a receptor gene and infused it to the ventral pallidum of sexually naïve polygamous montane voles. This viral gene transfection was successful—the montane males subsequently displayed both sexual and parental monogamy, and the V1a receptor populations had grown in density. Thus, relative differences in brain vasopressin transmission can alter patterns of preference and entire mating strategies.

    Article  CAS  PubMed  Google Scholar 

  43. Kippin TE, Talianakis S, Schattmann L, et al.: Olfactory conditioning of sexual behavior in the male rat. J Comp Psychol 1998, 112:389–399.

    Article  Google Scholar 

  44. Coria-Avila G, Ouimet AJ, Pacheco P, et al.: Olfactory conditioned partner preference in the female rat. Behav Neurosci 2005, In press.

  45. Holstege G, Georgiadis JR, Paans AM, et al.: Brain activation during human male ejaculation. J Neurosci 2003, 23:9185–9193. This study used PET to examine the pattern of brain activation during ejaculation in men given manual stimulation of the penis. To control for facial motor artifacts during orgasm, subjects were instructed to make orgasm-like facial grimaces before the study, and the activated regional blood flow patterns in the brain associated with those grimaces was subtracted from the activation during the study. Ejaculation induced neocortical activation only on the right side, but bilateral activation was observed in the lateral putamen and claustrum; intralaminar thalamus; in midbrain regions such as the ventral tegmental area, central tegmental field, zona incerta, and subparafascicular nucleus; and in the cerebellum. This pattern of activation is nearly identical to that observed in male rats after ejaculation. However, unlike in the rat, decreased activation in the amygdala and entorhinal cortex was observed in men. Perhaps the most interesting finding was the massive activation of the cerebellum, a structure only recently thought to participate in emotional processing.

    CAS  PubMed  Google Scholar 

  46. Komisaruk BR, Whipple B, Crawford A, et al.: Brain activation during vaginocervical self-stimulation and orgasm in women with complete spinal cord injury: fMRI evidence of mediation by the vagus nerves. Brain Res 2004, 1024:77–88. This study used fMRI to examine the pattern of brain activation in women with complete spinal cord injury at T10 or above who are still capable of achieving orgasm through manual vaginocervical stimulation. Orgasm activated the regional blood oxygen level-dependent signal intensity in hypothalamic paraventricular nucleus; medial amygdala; anterior cingulate; frontal, parietal, and insular cortices; cerebellum; and brainstem regions such as the nucleus of the solitary tract—the main projection region of the Vagus nerve. As in women without spinal cord injury, orgasm also induced analgesia measured by tolerance to pressure intensity in the fingers of the nondominant hand. These results suggest that vagal afferents carried the orgasmrelevant information to the brain and activated both sensory and emotional systems involved in pleasure and pain modulation.

    Article  CAS  PubMed  Google Scholar 

  47. Bancroft J, Janssen E: The dual control model of male sexual response: a theoretical approach to centrally mediated erectile dysfunction. Neurosci Biobehav Rev 2000, 24:571–579.

    Article  CAS  PubMed  Google Scholar 

  48. Rodriguez-Manzo G: Blockade of the establishment of the sexual inhibition resulting from sexual exhaustion by the Coolidge effect. Behav Brain Res 1999, 100:245–254.

    Article  CAS  PubMed  Google Scholar 

  49. Pfaus JG, Wilkins MF: A novel environment disrupts copulation in sexually naïve but not experienced male rats: reversal with naloxone. Physiol Behav 1995, 57:1045–1049.

    Article  CAS  PubMed  Google Scholar 

  50. Fiorino DF, Phillips AG: Facilitation of sexual behavior in male rats following d-amphetamine-induced behavioral sensitization. Psychopharmacol 1999, 142:200–208.

    Article  CAS  Google Scholar 

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  1. Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, 7141 Sherbrooke West, H4B 1R6, Montréal, QC, Canada

    James G. Pfaus PhD

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  1. James G. Pfaus PhD
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  2. Lisa A. Scepkowski MA
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Pfaus, J.G., Scepkowski, L.A. The biologic basis for libido. Current Sexual Health Reports 2, 95–100 (2005). https://doi.org/10.1007/s11930-005-0010-2

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