Article

Current Rheumatology Reports

, Volume 13, Issue 3, pp 233-240

Open Access This content is freely available online to anyone, anywhere at any time.

Advances in Glucocorticoid-Induced Osteoporosis

  • Debby den UylAffiliated withDepartment of Rheumatology, VU University Medical Center
  • , Irene E. M. BultinkAffiliated withDepartment of Rheumatology, VU University Medical Center
  • , Willem F. LemsAffiliated withDepartment of Rheumatology, VU University Medical Center Email author 

Abstract

Glucocorticoid-induced osteoporosis (GIOP) is one of the most important side effects of glucocorticoid use, as it leads to an increased risk of fractures. Recently, many published studies have focused on the cellular and molecular mechanisms of bone metabolism, the pathophysiology of GIOP, and the intervention options to prevent GIOP. In this review, recent advances in GIOP are summarized, particularly recent progress in our understanding of the mechanisms of GIOP resulting in improved insight that might result in the development of new treatment options in the near future.

Keywords

Bone Glucocorticoids Osteoporosis