Gastroenterology Issues in Schizophrenia: Why the Gut Matters

  • Emily G. Severance
  • Emese Prandovszky
  • James Castiglione
  • Robert H. Yolken
Schizophrenia and Other Psychotic Disorders (SJ Siegel, Section Editor)

DOI: 10.1007/s11920-015-0574-0

Cite this article as:
Severance, E.G., Prandovszky, E., Castiglione, J. et al. Curr Psychiatry Rep (2015) 17: 27. doi:10.1007/s11920-015-0574-0
Part of the following topical collections:
  1. Topical Collection on Schizophrenia and Other Psychotic Disorders

Abstract

Genetic and environmental studies implicate immune pathologies in schizophrenia. The body’s largest immune organ is the gastrointestinal (GI) tract. Historical associations of GI conditions with mental illnesses predate the introduction of antipsychotics. Current studies of antipsychotic-naïve patients support that gut dysfunction may be inherent to the schizophrenia disease process. Risk factors for schizophrenia (inflammation, food intolerances, Toxoplasma gondii exposure, cellular barrier defects) are part of biological pathways that intersect those operant in the gut. Central to GI function is a homeostatic microbial community, and early reports show that it is disrupted in schizophrenia. Bioactive and toxic products derived from digestion and microbial dysbiosis activate adaptive and innate immunity. Complement C1q, a brain-active systemic immune component, interacts with gut-related schizophrenia risk factors in clinical and experimental animal models. With accumulating evidence supporting newly discovered gut–brain physiological pathways, treatments to ameliorate brain symptoms of schizophrenia should be supplemented with therapies to correct GI dysfunction.

Keywords

Microbiome Autoimmunity Blood–brain barrier Gluten Autism Synapses 

Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Emily G. Severance
    • 1
  • Emese Prandovszky
    • 1
  • James Castiglione
    • 2
  • Robert H. Yolken
    • 1
  1. 1.Stanley Division of Developmental Neurovirology, Department of PediatricsJohns Hopkins University School of MedicineBaltimoreUSA
  2. 2.Brooklyn CollegeThe City University of New YorkBrooklynUSA