Current Osteoporosis Reports

, Volume 11, Issue 1, pp 45–51

Bisphosphonate Drug Holiday: Choosing Appropriate Candidates

Authors

  • Cynthia Ro
    • Division of Endocrinology, Diabetes, and MetabolismCedars-Sinai Medical Center
    • Division of Endocrinology, Diabetes, and MetabolismCedars-Sinai Medical Center
Current Therapeutics (SL Silverman, Section Editor)

DOI: 10.1007/s11914-012-0129-9

Cite this article as:
Ro, C. & Cooper, O. Curr Osteoporos Rep (2013) 11: 45. doi:10.1007/s11914-012-0129-9

Abstract

Osteoporosis related fractures contribute to morbidity and mortality in U.S. patients, placing a heavy financial burden on society. Randomized clinical trials involving over 30,000 subjects have established bisphosphonates’ efficacy in reducing the incidence of fragility fractures. However, as bisphosphonates are retained for years in the skeleton, reports of adverse events from prolonged use are surfacing in the literature, namely, esophageal cancer, atrial fibrillation, osteonecrosis of the jaw, and atypical fracture development. The concept of a drug holiday has been proposed to potentially reduce incidence of these adverse events. This review will highlight the benefits and risks of bisphosphonate therapy and discuss the extension data available from the bisphosphonate trials. As randomized clinical trial evidence is not yet available on who may qualify for drug holiday, this review will provide suggestions for clinicians on identification of possible candidates and monitoring during a bisphosphonate drug holiday.

Keywords

OsteoporosisBisphosphonateDrug holidayAtypical fracture

Copyright information

© Springer Science+Business Media New York 2013