Bisphosphonate Drug Holiday: Choosing Appropriate Candidates
Rent the article at a discountRent now
* Final gross prices may vary according to local VAT.Get Access
Osteoporosis related fractures contribute to morbidity and mortality in U.S. patients, placing a heavy financial burden on society. Randomized clinical trials involving over 30,000 subjects have established bisphosphonates’ efficacy in reducing the incidence of fragility fractures. However, as bisphosphonates are retained for years in the skeleton, reports of adverse events from prolonged use are surfacing in the literature, namely, esophageal cancer, atrial fibrillation, osteonecrosis of the jaw, and atypical fracture development. The concept of a drug holiday has been proposed to potentially reduce incidence of these adverse events. This review will highlight the benefits and risks of bisphosphonate therapy and discuss the extension data available from the bisphosphonate trials. As randomized clinical trial evidence is not yet available on who may qualify for drug holiday, this review will provide suggestions for clinicians on identification of possible candidates and monitoring during a bisphosphonate drug holiday.
- Bisphosphonate Drug Holiday: Choosing Appropriate Candidates
Current Osteoporosis Reports
Volume 11, Issue 1 , pp 45-51
- Cover Date
- Print ISSN
- Online ISSN
- Current Science Inc.
- Additional Links
- Drug holiday
- Atypical fracture
- Industry Sectors