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A Central Role for Hypoxic Signaling in Cartilage, Bone, and Hematopoiesis

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Abstract

Hypoxic signaling plays an essential role in maintaining oxygen homeostasis and cell survival. Hypoxia-inducible transcription factors HIF-1 and HIF-2 are central mediators of the cellular response to hypoxia by regulating the expression of genes controlling metabolic adaptation, oxygen delivery, and survival in response to oxygen deprivation. Recent studies have identified an important role for HIF-1 and HIF-2 in the regulation of skeletal development, bone formation, and regeneration, as well as joint formation and homeostasis. In addition, overexpression of HIF-1 and HIF-2 is clinically associated with osteosarcoma and osteoarthritis. Together, these findings implicate hypoxic signaling as a central regulator of bone biology and disease.

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Acknowledgment

This paper was supported by National Institutes of Health RO1 AR048191-06 to E. Schipani.

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Authors and Affiliations

  1. Endocrine Unit, Massachusetts General Hospital-Harvard Medical School, Boston, MA, 02114, USA

    Erinn B. Rankin & Ernestina Schipani

  2. Division of Radiation and Cancer Biology, Department of Radiation Oncology, Stanford University, Stanford, CA, 94303–5152, USA

    Erinn B. Rankin & Amato J. Giaccia

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  1. Erinn B. Rankin
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  2. Amato J. Giaccia
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Correspondence to Ernestina Schipani.

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Rankin, E.B., Giaccia, A.J. & Schipani, E. A Central Role for Hypoxic Signaling in Cartilage, Bone, and Hematopoiesis. Curr Osteoporos Rep 9, 46–52 (2011). https://doi.org/10.1007/s11914-011-0047-2

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