Assessment of Individual Fracture Risk: FRAX and Beyond
The World Health Organization fracture risk assessment tool (FRAX) and the Garvan fracture risk calculator are both widely available tools for individualized fracture risk prediction in daily practice. The FRAX model is implemented in several guidelines and most widely used at present. However, clinicians should take into account the differences between the models, especially with regard to the effect of the number of falls, number and clustering of previous fractures, and the number of clinical risk factors on the outcome of predicted fracture risk. Further development will be needed for optimal integration of bone- and fall-related risks, clustering of fractures, and dosing of risk factors to validate the models in different populations and to validate the ability to select patients who will achieve fracture risk reduction with anti-osteoporosis therapy. FRAX may be used as the primary model, and in patients with recurrent fractures and falls the use of the Garvan model may be of additional value.
- Assessment of Individual Fracture Risk: FRAX and Beyond
- Open Access
- Available under Open Access This content is freely available online to anyone, anywhere at any time.
Current Osteoporosis Reports
Volume 8, Issue 3 , pp 131-137
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- Current Science Inc.
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- Timing of fractures
- Risk factors
- Industry Sectors
- Author Affiliations
- 1. Department of Internal Medicine, VieCuri Medical Centre Noord-Limburg, P.O. Box 1926, 5900 BX, Venlo, The Netherlands
- 2. Faculty of Health Medicine and Life Science, Department of Internal Medicine, Maastricht University/Nutrim, P.O. Box 616, 6200 MD, Maastricht, The Netherlands
- 3. Faculty of Health Medicine and Life Science, Department of General Practice, Maastricht University/Caphri, P.O. Box 616, 6200 MD, Maastricht, The Netherlands
- 4. Department of Rheumatology, VU Medical Centre, P.O. Box 7057, 1007 MB, Amsterdam, The Netherlands
- 5. Faculty of Health Medicine and Life Science, Department of Internal Medicine, Maastricht University/Caphri, P.O. Box 616, 6200 MD, Maastricht, The Netherlands
- 6. Biomedical Research Center, University Hasselt, Hasselt, Belgium