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PPARs in Bone: The Role in Bone Cell Differentiation and Regulation of Energy Metabolism

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Abstract

Obesity, diabetes, and osteoporosis are major public health concerns. Current estimates indicate that the US population consists of 25% obese, 30% diabetic and prediabetic, and, among the elderly, 50% of all osteoporotic individuals. Mechanistically, these pathologies share several features including common regulators of bone homeostasis and energy metabolism. Peroxisome proliferator-activated receptors (PPARs) represent a family of proteins that control energy turnover in adipose, liver, and muscle tissue. These proteins also control bone turnover and regulate bone cell differentiation. Recent evidence suggests that bone is an organ integral to energy metabolism not only with respect to energy storage, but also as an organ regulating systemic energy homeostasis. In this article, we review current knowledge on the role of PPARs in bone metabolism and bone cell differentiation. We also discuss the role of bone fat in modulation of bone marrow microenvironment and its possible contribution to the systemic regulation of energy metabolism.

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Disclosure

Dr. Beata Lecka-Czernik has received support from funds from the US National Institutes of Health/National Institute on Aging (NIA AG 028935) and American Diabetes Association’s Amaranth Diabetes Fund 1-09-RA-95.

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  1. Departments of Orthopaedic Surgery and Physiology and Pharmacology, Center for Diabetes and Endocrine Research, University of Toledo Medical Center, 3000 Arlington Avenue, Toledo, OH, 43614, USA

    Beata Lecka-Czernik

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Correspondence to Beata Lecka-Czernik.

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Lecka-Czernik, B. PPARs in Bone: The Role in Bone Cell Differentiation and Regulation of Energy Metabolism. Curr Osteoporos Rep 8, 84–90 (2010). https://doi.org/10.1007/s11914-010-0016-1

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