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The osteogenic-angiogenic interface: Novel insights into the biology of bone formation and fracture repair

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Abstract

Bone never forms without vascular interactions. Although this is a very simple and obvious statement, the biological, clinical, and pharmacologic implications are incompletely appreciated. The vasculature is not only the conduit for nutrient-metabolite exchange and the rate-limiting “point-of-reference” for Haversian bone formation, but also provides the sustentacular niche for the self-renewing osteoprogenitor. This past year, significant advances have been made in our understanding of the osteogenic-angiogenic interface that are immediately germane to osteoporosis disease biology and fracture management. The critical contributions of the osteoblast oxygen-sensing machinery, paracrine vascular endothelial growth factor and placental growth factor signaling, fracture-mobilized circulating osteoprogenitors, and the osteogenic CD146(+) marrow sinusoid stem cell have been recently discovered. This brief review recounts these revelations, highlighting the potential impact to human bone health and fracture repair.

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  1. Internal Medicine-BMD, Washington University School of Medicine, Barnes-Jewish North Campus Box 8301, 660 South Euclid Avenue, St. Louis, MO, 63110, USA

    Dwight A. Towler

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Towler, D.A. The osteogenic-angiogenic interface: Novel insights into the biology of bone formation and fracture repair. Curr Osteoporos Rep 6, 67–71 (2008). https://doi.org/10.1007/s11914-008-0012-x

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