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Sinonasal Undifferentiated Carcinoma

  • Head and Neck Cancers (EY Hanna, Section Editor)
  • Published:
Current Oncology Reports Aims and scope Submit manuscript

Abstract

Purpose of Review

To provide a comprehensive review of the literature highlighting the recent advances in the diagnosis and management of sinonasal undifferentiated carcinoma (SNUC)

Recent Findings

SNUC usually presents at advanced stage and the prognosis is usually poor with high rates of locoregional recurrence and tendency to metastasize. Special attention should be made in differentiating SNUC from other sinonasal malignancies in order to guide the appropriate treatment accordingly. Multimodality treatment is usually recommended for treating SNUC. The use of neoadjuvant chemotherapy may be associated with improved outcome and can be used to guide the subsequent treatment selection.

Summary

Despite the recent advances in chemotherapeutic agents, radiation techniques, and surgical approaches, the prognosis and survival outcomes of SNUC remain poor. The addition of induction chemotherapy to the treatment approach followed by definitive local therapy needs to be further studied as it might improve the outcome.

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References

Papers of particular interest, published recently, have been highlighted as: • Of importance

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Authors and Affiliations

  1. Department of Head and Neck Surgery, Division of Surgery, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Unit 1445, Houston, TX, 77030, USA

    Ahmed S. Abdelmeguid & Ehab Y. Hanna

  2. Department of Otolaryngology Head and Neck Surgery, Faculty of Medicine, Mansoura University, Mansoura, Egypt

    Ahmed S. Abdelmeguid

  3. Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

    Diana Bell

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  1. Ahmed S. Abdelmeguid
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Correspondence to Ehab Y. Hanna.

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Abdelmeguid, A.S., Bell, D. & Hanna, E.Y. Sinonasal Undifferentiated Carcinoma. Curr Oncol Rep 21, 26 (2019). https://doi.org/10.1007/s11912-019-0776-4

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  • DOI: https://doi.org/10.1007/s11912-019-0776-4

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