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Prognostic Stratification of Patients With Advanced Oral Cavity Squamous Cell Carcinoma

  • Head and Neck Cancers (EY Hanna, Section Editor)
  • Published:
Current Oncology Reports Aims and scope Submit manuscript

Abstract

Purpose of Review

Prognosis of advanced oral squamous cell carcinoma remains a challenge for clinicians despite progress in its diagnosis and treatment over the past decades. In this review, we assessed clinicopathological factors and potential biomarkers along with their prognostic relevance in an attempt to develop optimal treatment strategies for these patients.

Recent Findings

In addition to several pathologic factors that have been proposed to improve prognostic stratification and treatment planning in the eighth edition of the American Joint Committee staging manual on cancer, we reviewed some other imaging and clinicopathological parameters demonstrated to be closely associated with patient prognosis, along with the biomarkers related to novel target or immune therapy.

Summary

Evaluation of current literature regarding the prognostic stratification used in contemporary clinicopathological studies and progress in the development of targeted or immune therapy may help these patients benefit from tailored and personalized treatment and obtain better oncological results.

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Authors and Affiliations

  1. Department of Otolaryngology-Head and Neck Surgery, Chang Gung Memorial Hospital, Taoyuan, Taiwan

    Dante De Paz & Kai-Ping Chang

  2. Department of Head and Neck Surgery, San Pedro University, Chimbote, Peru

    Dante De Paz

  3. Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital, Taoyuan, Taiwan

    Huang-Kai Kao

  4. College of Medicine, Chang Gung University, Taoyuan, Taiwan

    Huang-Kai Kao, Yenlin Huang & Kai-Ping Chang

  5. Department of Pathology, Chang Gung Memorial Hospital, Taoyuan, Taiwan

    Yenlin Huang

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  1. Dante De Paz
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Correspondence to Kai-Ping Chang.

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Dante De Paz, Huang-Kai Kao, Yenlin Huang, and Kai-Ping Chang declare they have no conflict of interest.

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This article is part of the Topical Collection on Head and Neck Cancers

Dante De Paz and Huang-Kai Kao contribute equally to this work.

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De Paz, D., Kao, HK., Huang, Y. et al. Prognostic Stratification of Patients With Advanced Oral Cavity Squamous Cell Carcinoma. Curr Oncol Rep 19, 65 (2017). https://doi.org/10.1007/s11912-017-0624-3

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  • DOI: https://doi.org/10.1007/s11912-017-0624-3

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