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Current Management Strategy for Metastatic Renal Cell Carcinoma and Future Directions

  • Genitourinary Cancers (DP Petrylak and JW Kim, Section Editors)
  • Published:
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Abstract

Purpose of Review

Major strides have been made in the treatment of kidney cancer in the last several years with checkpoint immunotherapies and novel targeted agents. This manuscript will review current treatment strategies for metastatic renal cell carcinoma and will discuss future directions.

Recent Findings

Most recently, several new drugs including nivolumab, cabozantinib, and a combination of lenvatinib and everolimus have demonstrated acceptable toxicity and significantly improved overall survival, but evidence-based guidelines for sequencing of the approved treatment options and treatment selection based on biomarkers are still missing.

Summary

Despite the significant progress, many questions still remain unanswered. Several ongoing clinical trials are evaluating sequencing, timing of cytoreductive nephrectomy, combinations of immunotherapies and targeted therapies as well as selection of the best systemic treatment. Personalized treatment based on tumor profiling is one of the brightest spots on the horizon.

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Authors and Affiliations

  1. Fox Chase Cancer Center, 333 Cottman Ave, Philadelphia, PA, 19111, USA

    Hussein Merza

  2. National Cancer Institute, Center for Cancer Research, Building 10, Room B2L324B, Bethesda, MD, 20892, USA

    Marijo Bilusic

Authors
  1. Hussein Merza
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  2. Marijo Bilusic
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Correspondence to Marijo Bilusic.

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Conflict of Interest

Hussein Merza and Marijo Bilusic declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

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This article is part of the Topical Collection on Genitourinary Cancers

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Merza, H., Bilusic, M. Current Management Strategy for Metastatic Renal Cell Carcinoma and Future Directions. Curr Oncol Rep 19, 27 (2017). https://doi.org/10.1007/s11912-017-0583-8

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  • DOI: https://doi.org/10.1007/s11912-017-0583-8

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