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The Gut Microbiome and Obesity

  • Integrative Care (C Lammersfeld, Section Editor)
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Abstract

The gut microbiome consists of trillions of bacteria which play an important role in human metabolism. Animal and human studies have implicated distortion of the normal microbial balance in obesity and metabolic syndrome. Bacteria causing weight gain are thought to induce the expression of genes related to lipid and carbohydrate metabolism thereby leading to greater energy harvest from the diet. There is a large body of evidence demonstrating that alteration in the proportion of Bacteroidetes and Firmicutes leads to the development of obesity, but this has been recently challenged. It is likely that the influence of gut microbiome on obesity is much more complex than simply an imbalance in the proportion of these phyla of bacteria. Modulation of the gut microbiome through diet, pre- and probiotics, antibiotics, surgery, and fecal transplantation has the potential to majorly impact the obesity epidemic.

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References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. Baquero F, Nombela C. The microbiome as a human organ. Clin Microbiol Infect. 2012;4:2–4.

    Article  Google Scholar 

  2. Whitman WBCD, Wiebe WJ. Prokaryotes: the unseen majority. Proc Natl Acad Sci. 1998;95:6578–83.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Blaut M, Clavel T. Metabolic diversity of the intestinal microbiota: implications for health and disease. J Nutr. 2007;137:751S–5.

    CAS  PubMed  Google Scholar 

  4. Bäckhed F, Ding H, Wang T, et al. The gut microbiota as an environmental factor that regulates fat storage. Proc Natl Acad Sci U S A. 2004;101:15718–23.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Nieuwdorp M, Gilijamse PW, Pai N, Kaplan LM. Role of the microbiome in energy regulation and metabolism. Gastroenterology. 2014;146:1525–33.

    Article  CAS  PubMed  Google Scholar 

  6. Hooper LV, Macpherson AJ. Immune adaptations that maintain homeostasis with the intestinal microbiota. Nat Rev Immunol. 2010;10:159–69.

    Article  CAS  PubMed  Google Scholar 

  7. Turner JR. Intestinal mucosal barrier function in health and disease. Nat Rev Immunol. 2009;9:799–809.

    Article  CAS  PubMed  Google Scholar 

  8. Turnbaugh PJ, Ley RE, Mahowald MA, Magrini V, Mardis ER, Gordon JI. An obesity-associated gut microbiome with increased capacity for energy harvest. Nature. 2006;444:1027–131.

    Article  PubMed  Google Scholar 

  9. Vandeputte D, Falony G, Vieira-Silva S, Tito RY, Joossens M, Raes J. Stool consistency is strongly associated with gut microbiota richness and composition, enterotypes and bacterial growth rates. Gut. 2016;65:57–62.

    Article  CAS  PubMed  Google Scholar 

  10. Okeke F, Roland BC, Mullin GE. The role of the gut microbiome in the pathogenesis and treatment of obesity. Glob Adv Health Med. 2014;3(3):44–57.

  11. Mullin GE. Gut Microbiome imbalance: pathways to weight gain and illness. Alternative and Complementary Therapies. 2015;21(4):161–62.

  12. WHO. BMI classification. In: World Health Organization; 2015. http://apps.who.int/bmi/index.jsp?introPage=intro_3.htm

  13. Consortium THMP. Structure, function and diversity of the healthy human microbiome. Nature. 2012;486:207–14.

    Article  Google Scholar 

  14. Tremaroli V, Backhed F. Functional interactions between the gut microbiota and host metabolism. Nature. 2012;489:242–9.

    Article  CAS  PubMed  Google Scholar 

  15. Calle EE, Thun MJ. Obesity and cancer. Oncogene. 2004;23:6365–78.

    Article  CAS  PubMed  Google Scholar 

  16. Calle EE, Rodriguez C, Walker-Thurmond K, Thun MJ. Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. New Engl J Med. 2003;348:1625–38.

    Article  PubMed  Google Scholar 

  17. Mullin GE. The gut balance revolution: boost your metabolism, restore your inner ecology, and lose the weight for good! Emmaus: Rodale; 2015.

  18. Wallace JG, Gohir W, Sloboda DM. The impact of early life gut colonization on metabolic and obesogenic outcomes: what have animal models shown us? J Dev Orig Health Dis. 2016;7:15–24. This paper reviews early gut colonization in animal models focusing especially on the role of the early gut microbiome in impacting disease later in life.

    Article  CAS  PubMed  Google Scholar 

  19. Jiménez E, Marín ML, Martín R, et al. Is meconium from healthy newborns actually sterile? Res Microbiol. 2008;159:187–93.

    Article  PubMed  Google Scholar 

  20. Wang M, Radlowski EC, Monaco MH, Fahey GC, Gaskins HR, Donovan SM. Mode of delivery and early nutrition modulate microbial colonization and fermentation products in neonatal piglets. J Nutr. 2013;143:795–803.

    Article  CAS  PubMed  Google Scholar 

  21. Bäckhed F, Manchester JK, Semenkovich CF, Gordon JI. Mechanisms underlying the resistance to diet-induced obesity in germ-free mice. Proc Natl Acad Sci. 2007;104:979–84.

    Article  PubMed  PubMed Central  Google Scholar 

  22. Ley RE. Obesity and the human microbiome. Curr Opin Gastroenterol. 2010;26:5–11.

    Article  PubMed  Google Scholar 

  23. Ley RE, Backhed F, Turnbaugh P, Lozupone CA, Knight RD, Gordon JI. Obesity alters gut microbial ecology. Proc Natl Acad Sci U S A. 2005;102:11070–5.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  24. Turnbaugh PJ, Hamady M, Yatsunenko T, et al. A core gut microbiome in obese and lean twins. Nature. 2009;457:480–4.

    Article  CAS  PubMed  Google Scholar 

  25. Schwiertz A, Taras D, Schafer K, et al. Microbiota and SCFA in lean and overweight healthy subjects. Obesity. 2010;18:190–5.

    Article  PubMed  Google Scholar 

  26. Collado MC, Isolauri E, Laitinen K, Salminen S. Distinct composition of gut microbiota during pregnancy in overweight and normal-weight women. Am J Clin Nutr. 2008;88:894–9.

    CAS  PubMed  Google Scholar 

  27. Duncan SH, Lobley GE, Holtrop G, et al. Human colonic microbiota associated with diet, obesity and weight loss. Int J Obes. 2008;32:1720–4.

    Article  CAS  Google Scholar 

  28. Armougom F, Henry M, Vialettes B, Raccah D, Raoult D. Monitoring bacterial community of human gut microbiota reveals an increase in lactobacillus in obese patients and methanogens in anorexic patients. PLoS One. 2009;4(9):e7125. doi:10.1371/journal.pone.0007125.

  29. Balamurugan R, George G, Kabeerdoss J, Hepsiba J, Chandragunasekaran AM, Ramakrishna BS. Quantitative differences in intestinal Faecalibacterium prausnitzii in obese Indian children. Br J Nutr. 2010;103:335–8.

    Article  CAS  PubMed  Google Scholar 

  30. Damms-Machado A, Mitra S, Schollenberger AE, et al. Effects of surgical and dietary weight loss therapy for obesity on gut microbiota composition and nutrient absorption. Biomed Res Int. 2015;806248:1.

    Article  Google Scholar 

  31. Furet J-P, Kong L-C, Tap J, et al. Differential adaptation of human gut microbiota to bariatric surgery-induced weight loss: links with metabolic and low-grade inflammation markers. Diabetes. 2010;59:3049–57.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  32. Kalliomaki M, Collado MC, Salminen S, Isolauri E. Early differences in fecal microbiota composition in children may predict overweight. Am J Clin Nutr. 2008;87:534–8.

    CAS  PubMed  Google Scholar 

  33. Nadal I, Santacruz A, Marcos A, et al. Shifts in clostridia, bacteroides and immunoglobulin-coating fecal bacteria associated with weight loss in obese adolescents. Int J Obes. 2009;33:758–67.

    Article  CAS  Google Scholar 

  34. Santacruz A, Marcos A, Warnberg J, et al. Interplay between weight loss and gut microbiota composition in overweight adolescents. Obesity. 2009;17:1906–15.

    Article  PubMed  Google Scholar 

  35. Sotos M, Nadal I, Marti A, et al. Gut microbes and obesity in adolescents. Proceed Nutr Soc. 2008;67:null-null.

  36. Woodard GA, Encarnacion B, Downey JR, et al. Probiotics improve outcomes after Roux-en-Y gastric bypass surgery: a prospective randomized trial. J Gastrointest Surg. 2009;13:1198–204.

    Article  PubMed  Google Scholar 

  37. Zhang H, DiBaise JK, Zuccolo A, et al. Human gut microbiota in obesity and after gastric bypass. Proceedings of the National Academy of Sciences; 2009.

  38. Albenberg LG, Wu GD. Diet and the intestinal microbiome: associations, functions, and implications for health and disease. Gastroenterology. 2014;146:1564–72. This paper reviews the role of diet in impacting gut microbiome and its contribution in the pathogenesis of various disorders including obesity, coronary artery disease and inflammatory bowel disease.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  39. Dominguez-Bello MG, Costello EK, Contreras M, et al. Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns. Proc Natl Acad Sci. 2010;107:11971–5.

    Article  PubMed  PubMed Central  Google Scholar 

  40. Wang M, Li M, Chapkin RS, Ivanov I, Donovan SM. Fecal microbiome and metabolites differ between breast and formula-fed human infants. FASEB J. 2013;27:850–4.

    CAS  Google Scholar 

  41. Koenig JE, Spor A, Scalfone N, et al. Succession of microbial consortia in the developing infant gut microbiome. Proc Natl Acad Sci. 2011;108:4578–85.

    Article  CAS  PubMed  Google Scholar 

  42. De Filippo C, Cavalieri D, Di Paola M, et al. Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa. Proc Natl Acad Sci. 2010;107:14691–6.

    Article  PubMed  PubMed Central  Google Scholar 

  43. Turnbaugh PJ, Bäckhed F, Fulton L, Gordon JI. Diet-induced obesity is linked to marked but reversible alterations in the mouse distal gut microbiome. Cell Host Microbe. 2008;3:213–23.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  44. Ley RE, Turnbaugh PJ, Klein S, Gordon JI. Microbial ecology: human gut microbes associated with obesity. Nature. 2006;444:1022–3.

    Article  CAS  PubMed  Google Scholar 

  45. Chassaing B, Koren O, Goodrich JK, et al. Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome. Nature. 2015;519:92–6. This study was one of the first studies focusing on dietary emulsifiers which are commonly used in the food industry. The authors demonstrated that the use of relatively low concentrations of two commonly used emulsifiers, carboxymethylcellulose and polysorbate-80, induced alterations in the gut flora associated with the development of colitis and onset of metabolic syndrome with increase in adiposity and weight and impaired glycemic control which was transmissible by fecal transplantation into germ free mice.

    Article  CAS  PubMed  Google Scholar 

  46. Singh M, Mullin GE. Diet and environmental influences on the gut microbiome. In: Cohen A, vom Saal F editors. Integrative Environmental Medicine. Oxford: Univ Press; 2016.

  47. Brahe LK, Astrup A, Larsen LH. Can we prevent obesity-related metabolic diseases by dietary modulation of the gut microbiota? Advan Nutrit Int Rev J. 2016;7:90–101.

    Article  Google Scholar 

  48. Million M, Raoult D. The role of the manipulation of the gut microbiota in obesity. Curr Infect Dis Rep. 2012;15:25–30.

    Article  Google Scholar 

  49. Pineiro M, Asp NG, Reid G, Macfarlane S, Morelli L, Brunser O, Tuohy K. FAO Technical meeting on prebiotics. J Clin Gastroenterol. 2008;42(Suppl 3 Pt 2):S156–9.

  50. Gibson GR, Roberfroid MB. Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics. J Nutr. 1995;125:1401–12.

    CAS  PubMed  Google Scholar 

  51. Jackson KG, Taylor GR, Clohessy AM, Williams CM. The effect of the daily intake of inulin on fasting lipid, insulin and glucose concentrations in middle-aged men and women. Br J Nutr. 1999;82:23–30.

    Article  CAS  PubMed  Google Scholar 

  52. Delzenne NM, Cani PD, Neyrinck AM. Modulation of glucagon-like peptide 1 and energy metabolism by inulin and oligofructose: experimental data. J Nutr. 2007;137:2547S–51.

    CAS  PubMed  Google Scholar 

  53. Cani PD, Delzenne NM. The role of the gut microbiota in energy metabolism and metabolic disease. Curr Pharm Des. 2009;15:1546–58.

    Article  CAS  PubMed  Google Scholar 

  54. Kaczmarczyk MM, Miller MJ, Freund GG. The health benefits of dietary fiber: beyond the usual suspects of type 2 diabetes mellitus, cardiovascular disease and colon cancer. Metabolism. 2012;61:1058–66.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  55. Rowland I, Capurso L, Collins K, et al. Current level of consensus on probiotic science—report of an expert meeting—London, 23 November 2009. Gut Microbe. 2010;1:436–9.

    Article  Google Scholar 

  56. Begley M, Hill C, Gahan CG. Bile salt hydrolase activity in probiotics. Appl Environ Microbiol. 2006;72:1729–38.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  57. Mullin GE, Delzenne NM. The human gut micobiome and its role in obesity and the metabolic syndrome. In: Mullin GE, Cheskin L, Matarese L, editors. Integrative weight management. New York: Springer Publ; 2014.

  58. Butaye P, Devriese LA, Haesebrouck F. Antimicrobial growth promoters used in animal feed: effects of less well known antibiotics on gram-positive bacteria. Clin Microbiol Rev. 2003;16:175–88.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  59. Cho I, Yamanishi S, Cox L, et al. Antibiotics in early life alter the murine colonic microbiome and adiposity. Nature. 2012;488:621–6.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  60. Cox Laura M, Yamanishi S, Sohn J, et al. Altering the intestinal microbiota during a critical developmental window has lasting metabolic consequences. Cell. 2014;158:705–21. This study focused on the effect of low dose penicillin in weaning mice which caused changes in the ileal expression of genes involved in immunity as well as enhancement in the effect of diet induced obesity by its effects of gene expression in the liver, metabolic hormone levels and visceral adiposity with the trait being transferrable to germ free showing that the altered microbiota and not the antibiotics per se cause promotion of adiposity.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  61. Thuny F, Richet H, Casalta JP, Angelakis E, Habib G, Raoult D. Vancomycin treatment of infective endocarditis is linked with recently acquired obesity. PLoS One. 2010;5:0009074.

  62. Atherton JC, Blaser MJ. Coadaptation of helicobacter pylori and humans: ancient history, modern implications. J Clin Invest. 2009;119:2475–87.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  63. Francois F, Roper J, Joseph N, et al. The effect of H. pylori eradication on meal-associated changes in plasma ghrelin and leptin. BMC Gastroenterol. 2011;11:11–37.

    Article  Google Scholar 

  64. Zhang Y, Du T, Chen X, Yu X, Tu L, Zhang C. Association between helicobacter pylori infection and overweight or obesity in a Chinese population. J Infect Dev Ctries. 2015;9:945–53.

    Article  PubMed  Google Scholar 

  65. Xu C, Yan M, Sun Y, et al. Prevalence of helicobacter pylori infection and its relation with body mass index in a Chinese population. Helicobacter. 2014;19:437–42.

    Article  PubMed  Google Scholar 

  66. Mullin GE. Probiotics in digestive disease. Nutr Clin Pract. 2012;27(2):300–2.

  67. van Nood E, Vrieze A, Nieuwdorp M, et al. Duodenal infusion of donor feces for recurrent clostridium difficile. N Engl J Med. 2013;368:407–15.

    Article  PubMed  Google Scholar 

  68. Alang N, Kelly CR. Weight gain after fecal microbiota transplantation. Open Forum Infect Dis. 2015;2. The authors report a case of a 32 year old woman with a 41 lb unintentional weight gain following fecal transplantation from a related, overweight donor which highlights the importance of further studies to study the long term risks and benefits of fecal transplantation.

  69. Sweeney TE, Morton JM. The human gut microbiome: a review of the effect of obesity and surgically induced weight loss. JAMA Surg. 2013;148:563–9. This review focuses on the changes in the distal gut microbiome after Roux-en-Y gastric bypass and weight loss and discusses further clinical applications of studies of the distal gut microbiome.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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  1. Division of Gastroenterology and Hepatology, Johns Hopkins Hospital, 600 N. Wolfe Street, Baltimore, MD, 21287, USA

    George Kunnackal John & Gerard E. Mullin

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  1. George Kunnackal John
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  2. Gerard E. Mullin
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Correspondence to Gerard E. Mullin.

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George Kunnackal John and Gerard E. Mullin declare that they have no conflict of interest.

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John, G.K., Mullin, G.E. The Gut Microbiome and Obesity. Curr Oncol Rep 18, 45 (2016). https://doi.org/10.1007/s11912-016-0528-7

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