Current Neurology and Neuroscience Reports

, Volume 11, Issue 4, pp 371–378

Mild Cognitive Impairment in Parkinson’s Disease

Authors

    • Centre for Age-Related Diseases, Division of PsychiatryStavanger University Hospital
    • Karolinska Institutet, Department NVS, KI Alzheimer Disease Research Center
  • Kolbjørn Brønnick
    • Norwegian Centre for Movement DisordersStavanger University Hospital
  • Tormod Fladby
    • Department of NeurologyAkershus University Hospital
    • Faculty Division Akershus University HospitalUniversity of Oslo
Article

DOI: 10.1007/s11910-011-0203-1

Cite this article as:
Aarsland, D., Brønnick, K. & Fladby, T. Curr Neurol Neurosci Rep (2011) 11: 371. doi:10.1007/s11910-011-0203-1

Abstract

Prospective studies conducted during the last decade have shown that the majority of patients with Parkinson’s disease (PD) develop dementia. In addition, using a variety of definitions and methods, more recent research suggests that approximately a quarter of PD patients without dementia have mild cognitive impairment (PD-MCI). Furthermore, several studies have shown that approximately 20% have MCI even at time of diagnosis of PD. The typical cognitive deficits include visuospatial, attentional, and executive deficits, but memory deficits have also been shown. The etiology of PD-MCI is not known, but it is likely that mechanisms known to contribute to dementia in PD (ie, limbic and cortical Lewy bodies, amyloid plaques, and cholinergic deficits) play a role, in addition to dysfunction of dopaminergic frontostriatal circuits. PD-MCI predicts a shorter time to dementia, and preliminary evidence suggests that this is particularly true for posterior cognitive deficits. There are currently no systematic clinical trials in PD-MCI.

Keywords

Parkinson’s disease Cognitive impairment Dementia Visuospatial functions Executive functions Memory Attention Imaging Biomarker Cerebrospinal fluid Pathology Dopamine Acetylcholine Noradrenaline

Copyright information

© Springer Science+Business Media, LLC 2011