Current Infectious Disease Reports

, 13:561

Gynecologic Clostridial Toxic Shock in Women of Reproductive Age

Authors

    • Division of Reproductive HealthCenters for Disease Control and Prevention
  • Jeannette Guarner
    • Department of Pathology and Laboratory MedicineEmory University School of Medicine, Emory University Hospital
Urinary Tract Infections (Jack D. Sobel, Section Editor)

DOI: 10.1007/s11908-011-0207-7

Cite this article as:
Zane, S. & Guarner, J. Curr Infect Dis Rep (2011) 13: 561. doi:10.1007/s11908-011-0207-7

Abstract

Clostridial toxic shock, caused by Clostridium sordellii or Clostridium perfringens, is a rare and largely fatal syndrome among reproductive-aged women with genital tract infection, and may occur following various pregnancy outcomes or without pregnancy. Clinicians should be aware of common clinical features of this very rapidly-progressing syndrome including abdominal pain, tachycardia, hypotension, third-space fluid accumulations, hemoconcentration, and marked leukemoid response, often with lack of fever. In this review, we summarize known cases through mid-2011 and information on clinical presentation, diagnosis, treatment, and results of recent investigations regarding pathogenesis, including germination, toxins, and host response that may have important implications for development of preventive or therapeutic interventions.

Keywords

ClostridiumToxic shockEndometritisMyometritisPregnancyAbortionMifepristoneLeukemoidToxinsLethal toxinClostridium sordelliiClostridium perfringensGynecologicObstetricMolecular diagnosisPathogeneses

Copyright information

© Springer Science+Business Media, LLC (outside the USA)  2011