Current HIV/AIDS Reports

, Volume 6, Issue 1, pp 20–28

HIV infection of the genital mucosa in women

Article

DOI: 10.1007/s11904-009-0004-1

Cite this article as:
Hladik, F. & Hope, T.J. Curr HIV/AIDS Rep (2009) 6: 20. doi:10.1007/s11904-009-0004-1

Abstract

The vast majority of new HIV infections are acquired via the genital and rectal mucosa. Here, we provide an overview of our current knowledge of how HIV establishes local infection, with an emphasis on viral invasion through the female genital tract. Studies using human explant tissues and in vivo animal studies have improved our understanding of the cellular and molecular pathways of infection; this information could be harnessed to design effective HIV vaccines and microbicides.

Copyright information

© Current Medicine Group LLC 2009

Authors and Affiliations

  1. 1.Fred Hutchinson Cancer Research CenterSeattleUSA