Current HIV/AIDS Reports

, Volume 6, Issue 1, pp 20-28

First online:

HIV infection of the genital mucosa in women

  • Florian HladikAffiliated withFred Hutchinson Cancer Research Center Email author 
  • , Thomas J. Hope

Rent the article at a discount

Rent now

* Final gross prices may vary according to local VAT.

Get Access


The vast majority of new HIV infections are acquired via the genital and rectal mucosa. Here, we provide an overview of our current knowledge of how HIV establishes local infection, with an emphasis on viral invasion through the female genital tract. Studies using human explant tissues and in vivo animal studies have improved our understanding of the cellular and molecular pathways of infection; this information could be harnessed to design effective HIV vaccines and microbicides.