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Making β Cells from Adult Cells Within the Pancreas

  • Transplantation (A Pileggi, Section Editor)
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Abstract

Cell therapy is currently considered as a potential therapeutic alternative to traditional treatments of diabetes. Islet and whole pancreas transplantations provided the proof-of-concept of glucose homeostasis restoration after replenishment of the deficiency of β cells responsible for the disease. Current limitations of these procedures have led to the search for strategies targeting replication of pre-existing β cells or transdifferentiation of progenitors and adult cells. These investigations revealed an unexpected plasticity towards β cells of adult cells residing in pancreatic epithelium (eg, acinar, duct, and α cells). Here we discuss recent developments in β-cell replication and β-cell transdifferentiation of adult epithelial pancreatic cells, with an emphasis on techniques with a potential for clinical translation.

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Philippe A. Lysy declares that he has no conflict of interest. Gordon C. Weir declares that he has no conflict of interest. Susan Bonner-Weir declares that she has no conflict of interest.

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Authors and Affiliations

  1. Institut de Recherche Expérimentale et Clinique, Pôle de Pédiatrie, Avenue Hippocrate 10, 1200, Brussels, Belgium

    Philippe A. Lysy

  2. Joslin Diabetes Center, Harvard Stem Cell Institute, Harvard Medical School, 1 Joslin Place, Boston, MA, 02215, USA

    Gordon C. Weir & Susan Bonner-Weir

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  1. Philippe A. Lysy
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  2. Gordon C. Weir
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  3. Susan Bonner-Weir
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Correspondence to Susan Bonner-Weir.

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Lysy, P.A., Weir, G.C. & Bonner-Weir, S. Making β Cells from Adult Cells Within the Pancreas. Curr Diab Rep 13, 695–703 (2013). https://doi.org/10.1007/s11892-013-0400-1

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