Current Diabetes Reports

, 8:192

Genes and type 2 diabetes mellitus

Authors

    • Department of Clinical Sciences/Diabetes & EndocrinologyLund University, University Hospital Malmoe
  • Valeriya Lyssenko
Article

DOI: 10.1007/s11892-008-0033-y

Cite this article as:
Groop, L. & Lyssenko, V. Curr Diab Rep (2008) 8: 192. doi:10.1007/s11892-008-0033-y

Abstract

In 2007, five whole genome-wide association studies were published on the genetics of type 2 diabetes mellitus (T2DM), followed by the discovery of 11 genes consistently associated with T2DM. This breakthrough provided the first glimpses of a complete picture of the disease’s genetic complexity. Currently, we are only beginning to understand how DNA methylation, histone acetylation, and deacetylation may introduce epigenetic changes throughout one’s lifetime. Such changes may influence age-related modifications in gene-expression that contribute to age-related diseases. In the future, the possibility of whole-genome DNA methylation studies may elucidate the extent of these epigenetic effects. This article reviews genes that have recently been determined to be associated with T2DM.

Copyright information

© Current Medicine Group LLC 2008