Current Colorectal Cancer Reports

, Volume 8, Issue 4, pp 325–330

Novel Therapeutics: NSAIDs, Derivatives, and Phosphodiesterases

Molecular Biology (S Anant, Section Editor)

DOI: 10.1007/s11888-012-0142-5

Cite this article as:
Tinsley, H.N. & Piazza, G.A. Curr Colorectal Cancer Rep (2012) 8: 325. doi:10.1007/s11888-012-0142-5

Abstract

The chemopreventive efficacy of nonsteroidal anti-inflammatory drugs (NSAIDs) for colorectal cancer has been well documented. However, long-term use of NSAIDs is precluded owing to potentially fatal toxicities associated with their mechanism of action involving cyclooxygenase (COX) inhibition. But studies have shown that their anticancer activity may be due, in part, to an off-target effect. Cyclic guanosine monophosphate (cGMP) phosphodiesterases (PDEs), which are responsible for negative regulation of cGMP signaling, are an attractive COX-independent target. cGMP signaling is aberrantly suppressed in cancer cells and its activation appears to be sufficient to inhibit tumor cell growth. Chemically modifying sulindac has produced a series of new derivatives that lack COX-inhibitory activity but have improved cGMP PDE inhibitory activity. This approach is proving to be a promising strategy for the discovery of improved agents for the prevention and/or treatment of colorectal cancer.

Keywords

SulindacColon cancerNonsteroidal anti-inflammatory drugCyclic guanosine monophosphatePhosphodiesterase

Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  1. 1.Department of BiologyChemistry and Mathematics, University of MontevalloMontevalloUSA
  2. 2.Drug Discovery Research CenterMitchell Cancer Institute, University of South AlabamaMobileUSA